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Distribution of pericentriolar material in multipolar spindles induced by colcemid treatment in chinese hamster ovary cells

open access: closedJournal of Cell Science, 1988
ABSTRACT Mitotic Chinese hamster ovary cells were obtained by treatment with microtubule drugs under various conditions, and the shape of spindles was analysed by phase-contrast microscopy of isolated spindles, and by indirect immunofluorescence staining of whole mitotic cells with anti-tubulin antibody.
Caterina Sellitto, Ryoko Kuriyama
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v-Src-induced nuclear localization of YAP is involved in multipolar spindle formation in tetraploid cells

Cellular Signalling, 2017
The protein-tyrosine kinase, c-Src, is involved in a variety of signaling events, including cell division. We have reported that v-Src, which is a mutant variant of the cellular proto-oncogene, c-Src, causes delocalization of Aurora B kinase, resulting in a furrow regression in cytokinesis and the generation of multinucleated cells. However, the effect
Keiko Kakae   +5 more
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Induction of multipolar spindle in Allium sativum.

Cytobios, 1979
The effect of the polyene antifungal antibiotic aureofungin on the chromosomes of Allium sativum was examined. Mitotic studies showed chromosomal abnormalities of metaphase and anaphase. Besides these anomalies, the alteration of the spindle, i.e. tri- to multipolar condition, was also observed in treatment with 100 microgram treatment for 24 h, and ...
P, Kumar   +3 more
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Abstract 1849: Determining the molecular requirements for paclitaxel-induced spindle multipolarity

Cancer Research, 2018
Abstract Paclitaxel (TaxolTM) and other microtubule poisons are standard chemotherapy agents used in the treatment of breast cancer. However, only a subset of patients experience positive therapeutic effects from these drugs, underscoring the importance of further mechanistic study.
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