Results 41 to 50 of about 147,555 (174)
Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo. [PDF]
PLoS ONE, 2007 BACKGROUND:The Ewing sarcoma breakpoint region 1 gene (EWSR1), also known as EWS, is fused to a number of different partner genes as a result of chromosomal translocation in diverse sarcomas.
Mizuki Azuma +3 more
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Scientific Reports, 2021 We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification.
Dilan Boodhai Jaunky +5 more
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Cells, 2021 Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain size with mild to moderate intellectual disability.
En-Ju Chou, Tang K. Tang
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Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells
Cancer Medicine, 2023 Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil +4 more
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Regulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells. [PDF]
PLoS ONE, 2014 During cell division integrin-linked kinase (ILK) has been shown to regulate microtubule dynamics and centrosome clustering, processes involved in cell cycle progression, and malignant transformation.
William K A Sikkema +6 more
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The centrosome and cell proliferation
Cell Division, 2006 Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or
Merdes Andreas, Srsen Vlastimil
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On the role of p53 in the cellular response to aneuploidy
Cell Reports, 2021 Summary: Most solid tumors are aneuploid, and p53 has been implicated as the guardian of the euploid genome. Previous experiments using human cell lines showed that aneuploidy induction leads to p53 accumulation and p21-mediated G1 cell cycle arrest.
Akshay Narkar +9 more
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Induction of Excess Centrosomes in Neural Progenitor Cells during the Development of Radiation-Induced Microcephaly. [PDF]
PLoS ONE, 2016 The embryonic brain is one of the tissues most vulnerable to ionizing radiation. In this study, we showed that ionizing radiation induces apoptosis in the neural progenitors of the mouse cerebral cortex, and that the surviving progenitor cells ...
Mikio Shimada +5 more
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CENP-W plays a role in maintaining bipolar spindle structure.
PLoS ONE, 2014 The CENP-W/T complex was previously reported to be required for mitosis. HeLa cells depleted of CENP-W displayed profound mitotic defects, with mitotic timing delay, disorganized prometaphases and multipolar spindles as major phenotypic consequences.
Agnieszka Kaczmarczyk, Kevin F Sullivan
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p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. [PDF]
PLoS Biology, 2006 Aneuploidy, frequently observed in premalignant lesions, disrupts gene dosage and contributes to neoplastic progression. Theodor Boveri hypothesized nearly 100 years ago that aneuploidy was due to an increase in centrosome number (multipolar mitoses) and
Kimberly M McDermott +5 more
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