Results 41 to 50 of about 1,789 (148)
CENP-W plays a role in maintaining bipolar spindle structure.
PLoS ONE, 2014 The CENP-W/T complex was previously reported to be required for mitosis. HeLa cells depleted of CENP-W displayed profound mitotic defects, with mitotic timing delay, disorganized prometaphases and multipolar spindles as major phenotypic consequences.
Agnieszka Kaczmarczyk, Kevin F Sullivan
doaj +1 more source
p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. [PDF]
PLoS Biology, 2006 Aneuploidy, frequently observed in premalignant lesions, disrupts gene dosage and contributes to neoplastic progression. Theodor Boveri hypothesized nearly 100 years ago that aneuploidy was due to an increase in centrosome number (multipolar mitoses) and
Kimberly M McDermott +5 more
doaj +1 more source
OLA1 is responsible for normal spindle assembly and SAC activation in mouse oocytes [PDF]
PeerJ, 2020 Background OLA1 is a member of the GTPase protein family; unlike other members, it possess both GTPase and ATPase activities, and can bind and hydrolyze ATP more efficiently than GTP.
Di Xie +4 more
doaj +2 more sources
, 2021 In the context of holography, we analyse aspects of supersymmetric geometries based on two-dimensional orbifolds known as spindles. By analysing spin$^c$ spinors on a spindle with an azimuthal rotation symmetry we show that under rather general conditions there are just two possibilities, called the `twist' and the `anti-twist', which are determined by
arxiv +1 more source
BMC Biology, 2005 Background The role of centrioles in mitotic spindle function remains unclear. One approach to investigate mitotic centriole function is to ask whether mutation of centriole-associated proteins can cause genomic instability. Results We addressed the role
Marshall Wallace F, Zamora Ivan
doaj +1 more source
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. [PDF]
PLoS ONE, 2011 Entry into and progression through mitosis depends on phosphorylation and dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal for exit from mitosis counteracting Cdk1-dependent phosphorylations.
Indra Tumurbaatar +4 more
doaj +1 more source
Unveil Sleep Spindles with Concentration of Frequency and Time [PDF]
arXiv, 2023 Objective: Sleep spindles contain crucial brain dynamics information. We introduce the novel non-linear time-frequency analysis tool 'Concentration of Frequency and Time' (ConceFT) to create an interpretable automated algorithm for sleep spindle annotation in EEG data and to measure spindle instantaneous frequencies (IFs).
arxiv
The Genotoxicity of Vitamin C in vitro
Biomolecules & Biomedicine, 2008 The genotoxic effects of Vitamin C (ascorbic acid) on human lymphocytes in vitro were estimated by analyzing and identifying various chromosome abnormalities, in relation to the concentration of Vitamin C.
Hilada Nefić
doaj +1 more source
Nature Communications, 2023 A tight synchrony between the DNA and centrosome cycle is essential for genomic integrity. Centriole disengagement, which licenses centrosomes for duplication, occurs normally during mitotic exit. We recently demonstrated that mild DNA replication stress
Devashish Dwivedi +2 more
doaj +1 more source
BMC Research Notes, 2009 Background Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more varied.
Miller Anne +2 more
doaj +1 more source