Results 51 to 60 of about 149,928 (237)

Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells

open access: yesScientific Reports, 2021
We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification.
Dilan Boodhai Jaunky   +5 more
doaj   +1 more source

Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics [PDF]

open access: yes, 2014
Glioma stem-cell-like cells are considered to be responsible for treatment resistance and tumour recurrence following chemo-radiation in glioblastoma patients, but specific targets by which to kill the cancer stem cell population remain elusive.
Chalmers, Anthony J.   +3 more
core   +3 more sources

Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position

open access: yesCells, 2021
Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain size with mild to moderate intellectual disability.
En-Ju Chou, Tang K. Tang
doaj   +1 more source

CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer. [PDF]

open access: yesCancer Res
Drugs that perturb microtubules are commonly used to treat breast cancers of all subtypes in both early stage and metastatic disease, but they are only effective in approximately 50% of patients.
Tucker JB   +5 more
europepmc   +2 more sources

Regulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells. [PDF]

open access: yesPLoS ONE, 2014
During cell division integrin-linked kinase (ILK) has been shown to regulate microtubule dynamics and centrosome clustering, processes involved in cell cycle progression, and malignant transformation.
William K A Sikkema   +6 more
doaj   +1 more source

Centrosome amplification disrupts renal development and causes cystogenesis [PDF]

open access: yes, 2018
International ...
Amanda Knoten   +79 more
core   +5 more sources

Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification. [PDF]

open access: yesCancer Gene Ther
Centrosome amplification (CA), an abnormal increase in the number of centrosomes in the cell, is a recurrent phenomenon in lung and other malignancies.
Zhang C   +14 more
europepmc   +2 more sources

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

open access: yes, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela   +7 more
core   +1 more source

四倍体がん細胞を由来としたがんの染色体不均一性の獲得および不均一性の薬剤治療への影響に関する研究 [PDF]

open access: yes, 2021
筑波大学University of Tsukuba博士(理学)Doctor of Philosophy in Science2020doctoral ...
UMEDA (SHU), Sei   +2 more
core   +1 more source

Towards Synthetic Life: Establishing a Minimal Segrosome for the Rational Design of Biomimetic Systems [PDF]

open access: yes, 2018
DNA segregation is a fundamental life process, crucial for renewal, reproduction and propagation of all forms of life. Hence, a dedicated segregation machinery, a segrosome, must function reliably also in the context of a minimal cell.
Hürtgen, Daniel
core   +1 more source

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