Scientific Reports, 2021 We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification.
Dilan Boodhai Jaunky +5 more
doaj +1 more source
Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics [PDF]
, 2014 Glioma stem-cell-like cells are considered to be responsible for treatment resistance and tumour recurrence following chemo-radiation in glioblastoma patients, but specific targets by which to kill the cancer stem cell population remain elusive.
Chalmers, Anthony J. +3 more
core +3 more sources
Cells, 2021 Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain size with mild to moderate intellectual disability.
En-Ju Chou, Tang K. Tang
doaj +1 more source
CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer. [PDF]
Cancer ResDrugs that perturb microtubules are commonly used to treat breast cancers of all subtypes in both early stage and metastatic disease, but they are only effective in approximately 50% of patients.
Tucker JB +5 more
europepmc +2 more sources
Regulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells. [PDF]
PLoS ONE, 2014 During cell division integrin-linked kinase (ILK) has been shown to regulate microtubule dynamics and centrosome clustering, processes involved in cell cycle progression, and malignant transformation.
William K A Sikkema +6 more
doaj +1 more source
Centrosome amplification disrupts renal development and causes cystogenesis [PDF]
, 2018 International ...
Amanda Knoten +79 more
core +5 more sources
Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification. [PDF]
Cancer Gene TherCentrosome amplification (CA), an abnormal increase in the number of centrosomes in the cell, is a recurrent phenomenon in lung and other malignancies.
Zhang C +14 more
europepmc +2 more sources
Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]
, 2017 Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela +7 more
core +1 more source
四倍体がん細胞を由来としたがんの染色体不均一性の獲得および不均一性の薬剤治療への影響に関する研究 [PDF]
, 2021 筑波大学University of Tsukuba博士（理学）Doctor of Philosophy in Science2020doctoral ...
UMEDA (SHU), Sei +2 more
core +1 more source
Towards Synthetic Life: Establishing a Minimal Segrosome for the Rational Design of Biomimetic Systems [PDF]
, 2018 DNA segregation is a fundamental life process, crucial for renewal, reproduction and propagation of all forms of life. Hence, a dedicated segregation machinery, a segrosome, must function reliably also in the context of a minimal cell.
Hürtgen, Daniel
core +1 more source