Results 51 to 60 of about 153,409 (229)

Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells

Scientific Reports, 2021
We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification.
Dilan Boodhai Jaunky, Kevin Larocque, Mathieu C. Husser, Jiang Tian Liu, Pat Forgione, Alisa Piekny   +5 more
doaj   +1 more source

A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer. [PDF]

, 2016
Numerical centrosome aberrations underlie certain developmental abnormalities and may promote cancer. A cell maintains normal centrosome numbers by coupling centrosome duplication with segregation, which is achieved through sustained association of each ...
Barr, Alexis R, Chandrasekaran, Gayathri, Chavali, Pavithra L, Chavali, Sreenivas, Gergely, Fanni, Papachristou, Evaggelia K, Taylor, Chris, Tátrai, Péter, Woods, C Geoffrey   +8 more
core   +6 more sources

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

Astrin regulates Aurora-A localization [PDF]

, 2008
Alterations in the expression and activity of the centrosomal kinase, Aurora-A/STK15, affect genomic stability, disrupt the fidelity of centrosome duplication, and induce cellular transformation.
Du, J., Hannon, G. J., Jablonski, S., Yen, T. J.   +3 more
core   +1 more source

Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position

Cells, 2021
Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain size with mild to moderate intellectual disability.
En-Ju Chou, Tang K. Tang
doaj   +1 more source

The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]

, 2015
Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
core   +1 more source

Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells

Cancer Medicine, 2023
Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil, Chandra S. Amara, Subrata Sen, Nagireddy Putluri, Randa El‐Zein   +4 more
doaj   +1 more source

Centrosome amplification disrupts renal development and causes cystogenesis [PDF]

, 2018
International ...
Amanda Knoten, Arquint, Astrinidis, Battini, Bettencourt-Dias, Bhaskar, Boehlke, Boletta, Brito, Brown, Burtey, Chang-Panesso, Chen, Chi, Coelho, Cosenza, Davenport, Dere, Distefano, Fisher, Ganem, Godinho, Godinho, Godinho, Goto, Habedanck, Hartman, Hendry, Hoshi, Jain, Jain, Janssen, Jinzhi Wang, Jonassen, Keefe Davis, Kobayashi, Krämer, Kulukian, Kyuhwan Shim, Lai Kuan Dionne, Levine, Lin, Ma, Mahjoub, Majumdar, Marthiens, Marthiens, Masato Hoshi, Masyuk, Moe R. Mahjoub, Mugford, Mundlos, Nano, Nigg, Nigg, Ogden, Patel, Quintyne, Renata Basto, Roselli, Saifudeen, Saifudeen, Sanjay Jain, Schmidt-Ott, Serçin, Shao, Sharma, Shillingford, Silkworth, Sillibourne, Simons, Srivastava, Takakura, Tammachote, Tao Cheng, Veronique Marthiens, Vitre, Werner, Yoder, Zhao   +79 more
core   +8 more sources

Regulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells. [PDF]

PLoS ONE, 2014
During cell division integrin-linked kinase (ILK) has been shown to regulate microtubule dynamics and centrosome clustering, processes involved in cell cycle progression, and malignant transformation.
William K A Sikkema, Arend Strikwerda, Manju Sharma, Kiran Assi, Baljinder Salh, Michael E Cox, Julia Mills   +6 more
doaj   +1 more source

Ipl1/aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis [PDF]

, 2013
Cells coordinate spindle formation with DNA repair and morphological modifications to chromosomes prior to their segregation to prevent cell division with damaged chromosomes.
A Hochwagen, A Sourirajan, AC Bishop, AJ MacQueen, BA Pinsky, BR Mardin, C Dahmann, CN Chuang, D Lydall, D Stuart, Dean S. Dawson, DK Bishop, E Okaz, E Smith, EL Woodbury, EO Shuster, Eva Hoffmann, F Klein, F Monje-Casas, H Hochegger, H Scherthan, I Acosta, I Fitch, J Pan, JA Carballo, Jesus A. Carballo, JY Leu, K Crasta, K Nasmyth, K Shirk, KA Henderson, KA Henderson, KN Smith, L Newnham, Louise Newnham, MP Miller, MT Bertran, N Grandin, P Jordan, P Jordan, Philip W. Jordan, PS Cheslock, R Padmore, RE Meyer, RK Clyne, S Chu, S Chu, S Kim, S Titus, SB Haase, Sonya Newcombe, TM Carlile   +51 more
core   +3 more sources