Results 51 to 60 of about 147,555 (174)

A mutation in the centriole-associated protein centrin causes genomic instability via increased chromosome loss in Chlamydomonas reinhardtii

BMC Biology, 2005
Background The role of centrioles in mitotic spindle function remains unclear. One approach to investigate mitotic centriole function is to ask whether mutation of centriole-associated proteins can cause genomic instability. Results We addressed the role
Marshall Wallace F, Zamora Ivan
doaj   +1 more source

Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. [PDF]

PLoS ONE, 2011
Entry into and progression through mitosis depends on phosphorylation and dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal for exit from mitosis counteracting Cdk1-dependent phosphorylations.
Indra Tumurbaatar, Onur Cizmecioglu, Ingrid Hoffmann, Ingrid Grummt, Renate Voit   +4 more
doaj   +1 more source

The Genotoxicity of Vitamin C in vitro

Biomolecules & Biomedicine, 2008
The genotoxic effects of Vitamin C (ascorbic acid) on human lymphocytes in vitro were estimated by analyzing and identifying various chromosome abnormalities, in relation to the concentration of Vitamin C.
Hilada Nefić
doaj   +1 more source

Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

Nature Communications, 2023
A tight synchrony between the DNA and centrosome cycle is essential for genomic integrity. Centriole disengagement, which licenses centrosomes for duplication, occurs normally during mitotic exit. We recently demonstrated that mild DNA replication stress
Devashish Dwivedi, Daniela Harry, Patrick Meraldi   +2 more
doaj   +1 more source

OLA1 is responsible for normal spindle assembly and SAC activation in mouse oocytes [PDF]

PeerJ, 2020
Background OLA1 is a member of the GTPase protein family; unlike other members, it possess both GTPase and ATPase activities, and can bind and hydrolyze ATP more efficiently than GTP.
Di Xie, Juan Zhang, JinLi Ding, Jing Yang, Yan Zhang   +4 more
doaj   +2 more sources

Localization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa

BMC Research Notes, 2009
Background Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more varied.
Miller Anne, Peters Nick T, Kropf Darryl L   +2 more
doaj   +1 more source

Endosulfine alpha maintains spindle pole integrity by recruiting Aurora A during mitosis

BMC Cancer, 2023
Background The maintenance of spindle pole integrity is essential for spindle assembly and chromosome segregation during mitosis. However, the underlying mechanisms governing spindle pole integrity remain unclear.
Seul Kim, Kyoungho Jun, Ye-Hyun Kim, Kwan-Young Jung, Jeong Su Oh, Jae-Sung Kim   +5 more
doaj   +1 more source

Colchicine Effect on the Mitotic Spindle: Estimate of Multipolar Anaphase Production

Caryologia, 1974
A study was made of the effect of colchicine on the mitotic spindle in onion root tips.The influence of temperature and time of exposure of dividing cells to the drug on the formation of multipolar...
M. E. Fernández-Gómez, J. P. Hervás, G. Giménez-Martín   +2 more
openaire   +2 more sources

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

eLife, 2021
Diaphanous (DIAPH) three (DIAPH3) is a member of the formin proteins that have the capacity to nucleate and elongate actin filaments and, therefore, to remodel the cytoskeleton.
Eva On-Chai Lau, Devid Damiani, Georges Chehade, Nuria Ruiz-Reig, Rana Saade, Yves Jossin, Mohamed Aittaleb, Olivier Schakman, Nicolas Tajeddine, Philippe Gailly, Fadel Tissir   +10 more
doaj   +1 more source

Characterization of the role of the tumor marker Nup88 in mitosis

Molecular Cancer, 2010
Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup).
Yoshida Kimihisa, Nakano Hiroshi, Hashizume Chieko, Wong Richard W   +3 more
doaj   +1 more source