Results 61 to 70 of about 147,555 (174)

NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between α-Adducin and Myosin X.

PLoS ONE, 2017
NIMA-related kinase 1 (NEK1) is a serine/threonine and tyrosine kinase that is highly expressed in mammalian germ cells. Mutations in Nek1 induce anemia, polycystic kidney and infertility.
Miguel A Brieño-Enríquez, Stefannie L Moak, J Kim Holloway, Paula E Cohen   +3 more
doaj   +1 more source

Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors. [PDF]

PLoS ONE, 2013
Developmental dynamics of neural stem/progenitor cells (NSPCs) are crucial for embryonic and adult neurogenesis, but its regulatory factors are not fully understood.
Takahito Yumoto, Kazuhiko Nakadate, Yuki Nakamura, Yoshinobu Sugitani, Reiko Sugitani-Yoshida, Shuichi Ueda, Shin-ichi Sakakibara   +6 more
doaj   +1 more source

Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

eLife, 2023
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells.
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi   +13 more
doaj   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice. [PDF]

PLoS Genetics, 2015
Skeletal dysplasias are a common, genetically heterogeneous cause of short stature that can result from disruptions in many cellular processes. We report the identification of the lesion responsible for skeletal dysplasia and male infertility in the ...
Krista A Geister, Michelle L Brinkmeier, Leonard Y Cheung, Jennifer Wendt, Melissa J Oatley, Daniel L Burgess, Kenneth M Kozloff, James D Cavalcoli, Jon M Oatley, Sally A Camper   +9 more
doaj   +1 more source

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

Cell Proliferation, EarlyView.
ECH protects senescent oocytes by stabilising the cytoskeleton, restoring mitochondrial function, reducing oxidative stress and maintaining cellular homeostasis, primarily through the GJA1/SIRT1 signalling pathway. ABSTRACT As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive ...
Liuqing Yang, Xinle Lai, Fangxuan Lin, Nan Shi, Xinya Xu, Heng Wang, Xiaotian Li, Dan Shen, Haimo Qian, Xin Jin, Jiayi Chen, Zhongwei Huang, Xing Duan, Qin Zhang   +13 more
wiley   +1 more source

Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss

Equine Veterinary Journal, EarlyView.
Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez, Alejandro de la Fuente, Kazuki Takahashi, Hugo Monteiro, Mauricio Mendes, Stuart Meyers, Pouya Dini   +6 more
wiley   +1 more source

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

Molecular Cancer, 2011
Background Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation ...
Asteriti Italia A, Giubettini Maria, Lavia Patrizia, Guarguaglini Giulia   +3 more
doaj   +1 more source

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity

Nature Communications, 2023
Male meiosis relies on canonical centrosomes for spindle formation, but how this differs from acentrosomal oocyte meiosis is unclear. Here they show that spindle formation in sperm relies on DYNLRB2, similar to the activity of DYNLRB1 in mitotic cells ...
Shuwen He, J. P. Gillies, Juliana L. Zang, Carmen M. Córdoba-Beldad, Io Yamamoto, Y. Fujiwara, J. Grantham, M. DeSantis, Hiroki Shibuya   +8 more
semanticscholar   +1 more source

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, EarlyView.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source