Results 61 to 70 of about 1,789 (148)
PLoS ONE, 2017 NIMA-related kinase 1 (NEK1) is a serine/threonine and tyrosine kinase that is highly expressed in mammalian germ cells. Mutations in Nek1 induce anemia, polycystic kidney and infertility.
Miguel A Brieño-Enríquez +3 more
doaj +1 more source
Characterization of the role of the tumor marker Nup88 in mitosis
Molecular Cancer, 2010 Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup).
Yoshida Kimihisa +3 more
doaj +1 more source
On-off intermittency of thalamo-cortical oscillations in the electroencephalogram of rats with genetic predisposition to absence epilepsy [PDF]
Brain research. 1436 (2012) 147-156, 2013 Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are known to originate from thalamo-cortical neuronal network that normally produce sleep spindle oscillations. Although both sleep spindles and SWD are considered as thalamo-cortical oscillations, functional relationship between them is still uncertain.
arxiv +1 more source
Toward a systems-level view of mitotic checkpoints [PDF]
Prog Biophys Mol Biol. 2015 Mar;117(2-3):217-24, 2016 Reproduction and natural selection are the key elements of life. In order to reproduce, the genetic material must be doubled, separated and placed into two new daughter cells, each containing a complete set of chromosomes and organelles. In mitosis, transition from one process to the next is guided by intricate surveillance mechanisms, known as the ...
arxiv +1 more source
An Indole Dearomatization Strategy for the Synthesis of Pseudo‐Natural Products
ChemBioChem, Accepted Article.The indole moiety is a privileged fragment that frequently populates existing bioactive compound collections. We describe the development of an indole‐dearomatization sequence and its application for library expansion of a collection of indole‐containing pseudo‐NPs.
Joseph G.F. Hoock +13 more
wiley +1 more source
The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.
PLoS ONEThe mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function ...
Renaldo Sutanto +6 more
doaj +1 more source
HN1 expression contributes to mitotic fidelity through Aurora A‐PLK1‐Eg5 axis
Cytoskeleton, EarlyView.Abstract Hematological and neurological expressed 1 (HN1) is homolog of Jupiter protein from Drosophila melanogaster where it functions as a microtubule‐associated protein. However, in mammalian cells, HN1 is associated partially with y‐tubulin in centrosomes, Stathmin for stabilizing microtubules, and Cdh1 for regulating Cyclin B1 for cell cycle ...
Gülseren Özduman +3 more
wiley +1 more source
Molecular Cancer, 2011 Background Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation ...
Asteriti Italia A +3 more
doaj +1 more source
Cell Proliferation, EarlyView.The regeneration of LC‐NE from pluripotent stem cells (PSCs) could significantly mitigate the progression of Neurodegenerative diseases and alleviate associated psychiatric disease symptoms, providing a new approach to the treatment of neurological diseases.
Yana Yang, Yunlong Tao
wiley +1 more source
Stabilization of turning processes using spindle feedback with state-dependent delay [PDF]
, 2017 We develop a stabilization strategy of turning processes by means of delayed spindle control. We show that turning processes which contain intrinsic state-dependent delays can be stabilized by a spindle control with state-dependent delay, and develop analytical description of the stability region in the parameter space.
arxiv +1 more source