Results 71 to 80 of about 1,789 (148)

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

Cell Proliferation, EarlyView.
ECH protects senescent oocytes by stabilising the cytoskeleton, restoring mitochondrial function, reducing oxidative stress and maintaining cellular homeostasis, primarily through the GJA1/SIRT1 signalling pathway. ABSTRACT As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive ...
Liuqing Yang, Xinle Lai, Fangxuan Lin, Nan Shi, Xinya Xu, Heng Wang, Xiaotian Li, Dan Shen, Haimo Qian, Xin Jin, Jiayi Chen, Zhongwei Huang, Xing Duan, Qin Zhang   +13 more
wiley   +1 more source

siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells

Insects
Silkworm ovary-derived BmN4 cells rely on chromatin-induced spindle assembly to form microtubule-based square mitotic spindles that ensure accurate segregation of holocentric chromosomes during cell division.
Bing Zhang, Camilo Ayra-Pardo, Xiaoning Liu, Meiting Song, Dandan Li, Yunchao Kan   +5 more
doaj   +1 more source

Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1. [PDF]

PLoS ONE, 2011
BACKGROUND: Highly Expressed in Cancer protein 1 (Hec1) is a constituent of the Ndc80 complex, a kinetochore component that has been shown to have a fundamental role in stable kinetochore-microtubule attachment, chromosome alignment and spindle ...
Marta Mattiuzzo, Giulia Vargiu, Pierangela Totta, Mario Fiore, Claudio Ciferri, Andrea Musacchio, Francesca Degrassi   +6 more
doaj   +1 more source

Hydrodynamic mechanism for stable spindle positioning in meiosis II oocytes [PDF]

PRX Life 2, 043003 (2024)
Cytoplasmic streaming, the persistent flow of fluid inside a cell, induces intracellular transport, which plays a key role in fundamental biological processes. In meiosis II mouse oocytes (developing egg cells) awaiting fertilisation, the spindle, which is the protein structure responsible for dividing genetic material in a cell, must maintain its ...
arxiv   +1 more source

Seasonal patterns of neurogenesis in European starlings (Sturnus vulgaris) are region‐ and sex‐specific

Journal of Neuroendocrinology, EarlyView.
Abstract Songbird vocal behavior, physiology, and brains—including neurogenesis—change between seasons. We examined seasonal differences in neurogenesis in three brain regions associated with vocal production and learning, HVC (letter‐based proper name), robust nucleus of the arcopallium (RA), and Area X, and two brain regions associated with auditory ...
Sean D. T. Aitken, Broderick. M. B. Parks, Marjorie Sollows, Colleen A. Barber, Leslie S. Phillmore   +4 more
wiley   +1 more source

Neuronal diversity in the caudate nucleus: A comparative study between camel and human brains

The Anatomical Record, Volume 308, Issue 5, Page 1410-1424, May 2025.
Abstract Caudate nucleus (CN) neurons in camels and humans were examined using modified Golgi impregnation methods. Neurons were classified based on soma morphology, dendritic characteristics, and spine distribution. Three primary neuron types were identified in both species: rich‐spiny (Type I), sparsely‐spiny (Type II), and aspiny (Type III), each ...
Juman M. Almasaad, Ziad M. Bataineh, Sami Zaqout   +2 more
wiley   +1 more source

Age‐associated accumulation of RAB9 disrupts oocyte meiosis

Aging Cell, Volume 24, Issue 4, April 2025.
This study showed that RAB9 protein accumulates in old human and mouse oocytes. RAB9 accumulation disrupted spindle formation, chromosome alignment and actin cap formation, increased ROS levels, decreased mitochondrial membrane potential, ATP content, mtDNA/nDNA ratio and activated the PINK1‐PARKIN pathway. Importantly, knockdown of RAB9 in old oocytes
Min Gao, Fang Wang, Tengteng Xu, Yanling Qiu, Tianqi Cao, Simiao Liu, Wenlian Wu, Yitong Zhou, Haiying Liu, Fenghua Liu, Junjiu Huang   +10 more
wiley   +1 more source

Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy

Advanced Therapeutics, Volume 8, Issue 2, February 2025.
The extracellular matrix (ECM) is pivotal in cancer progression, influencing tumor growth, metastasis, and therapy resistance. This paper explores ECM remodeling, highlighting components like collagens and proteoglycans, their impact on immune evasion, and emerging therapies targeting ECM mechanics and composition.
Nimeet Desai, Deepak Sahel, Bhakti Kubal, Humzah Postwala, Yesha Shah, Vivek P Chavda, Clara Fernandes, Dharmendra K. Khatri, Lalitkumar K. Vora   +8 more
wiley   +1 more source

CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment

Nature Cell Biology, 2012
Loss of spindle-pole integrity during mitosis leads to multipolarity independent of centrosome amplification. Multipolar-spindle conformation favours incorrect kinetochore-microtubule attachments, compromising faithful chromosome segregation and daughter-cell viability. Spindle-pole organization influences and is influenced by kinetochore activity, but
Patrick Meraldi, Stefano Maffini, Stefano Maffini, Helder Maiato, Helder Maiato, Alberto Toso, Andrea Marques, Andrea Marques, Elsa Logarinho, Marin Barisic   +9 more
openaire   +5 more sources

Pyruvate Kinase M2‐Responsive Release of Paclitaxel and Indoleamine 2,3‐Dioxygenase Inhibitor for Immuno‐Chemotherapy of Nonsmall Cell Lung Cancer

Advanced Science, Volume 12, Issue 7, February 17, 2025.
A smart peptide hydrogelator Nap‐T is designed to co‐deliver paclitaxel and indoleamine 2,3‐dioxygenase inhibitor GDC0919, achieving sustained drug release upon pyruvate kinase M2 phosphorylation for non‐small cell lung cancer treatment. GP@Gel Nap‐T enhances immuno‐chemotherapeutic effect by promoting cell apoptosis, immunogenic cell death effect, and
Haisi Wu, Xianbao Sun, Kaiming Li, Jinyu Li, Hui Jiang, Dan Yan, Ya Lin, Yan Ding, Yawen Lu, Xiaole Zhu, Xufeng Chen, Xiaolin Li, Gaolin Liang, Huae Xu   +13 more
wiley   +1 more source