Results 71 to 80 of about 147,555 (174)
Choice between 1- and 2-furrow cytokinesis in Caenorhabditis elegans embryos with tripolar spindles
bioRxiv, 2018 Excess numbers of centrosomes often lead to multipolar spindles, and thus probably to multipolar mitosis and aneuploidy. In Caenorhabditis elegans, approximately 70% of the paternal emb-27APC6 mutant embryonic cells contained more than 2 centrosomes and ...
T. Kondo, A. Kimura
semanticscholar +1 more source
Photochemistry and Photobiology, EarlyView.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Canine phaeochromocytomas (PCCs) are neuroendocrine tumours with malignant potential. Metastatic disease remains the sole definitive evidence of malignancy. Histopathological criteria to predict long‐term survival have not been established in dogs.
Marit F. van den Berg +6 more
wiley +1 more source
The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells.
Journal of Applied Biomedicine, 2019 Embryonic stem (ES) cells are pluripotent cells widely used in cell therapy and tissue engineering. However, the broader clinical applications of ES cells are limited by their genomic instability and karyotypic abnormalities.
V. Pospisilova +6 more
semanticscholar +1 more source
The Anatomical Record, Volume 308, Issue 9, Page 2433-2449, September 2025.Immunohistochemical staining for tyrosine hydroxylase reveals the neurons forming the locus coeruleus complex in the pontine region of the brain of the Congo gray parrot. The appearance and parcellation of the locus coeruleus complex in birds shows many similarities, but also differences to that observed in mammals.
Pedzisai Mazengenya, Paul R. Manger
wiley +1 more source
Nature Cell Biology, 2012 Loss of spindle-pole integrity during mitosis leads to multipolarity independent of centrosome amplification. Multipolar-spindle conformation favours incorrect kinetochore-microtubule attachments, compromising faithful chromosome segregation and daughter-cell viability. Spindle-pole organization influences and is influenced by kinetochore activity, but
Patrick Meraldi +9 more
openaire +5 more sources
Sinup is essential for the integrity of centrosomes and mitotic spindles in zebrafish embryos
Animal Cells and Systems, 2017 Fish lineage-specific gene, sinup [Siaz-interacting nuclear protein], modulates neural plate formation in embryogenesis and shares homology with human TPX2 protein, a member of the vertebrate mitogen-activating protein family. In spite of the presence of
Kyeong-Won Yoo +5 more
semanticscholar +1 more source
Food Science &Nutrition, Volume 13, Issue 8, August 2025.Similarly, polyphenols affect epigenetic marks and reduce oxidative stress and inflammation, both key drivers of PD pathology. Therefore, in this review, we explore how these interventions, individually and in combination, influence epigenetic mechanisms relevant to PD.
Xuenan Cao, Xiantao Cui, Bita Badehnoosh
wiley +1 more source
Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1. [PDF]
PLoS ONE, 2011 BACKGROUND: Highly Expressed in Cancer protein 1 (Hec1) is a constituent of the Ndc80 complex, a kinetochore component that has been shown to have a fundamental role in stable kinetochore-microtubule attachment, chromosome alignment and spindle ...
Marta Mattiuzzo +6 more
doaj +1 more source
Advanced Science, Volume 12, Issue 23, June 20, 2025.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source