Nature Communications, 2023 A tight synchrony between the DNA and centrosome cycle is essential for genomic integrity. Centriole disengagement, which licenses centrosomes for duplication, occurs normally during mitotic exit. We recently demonstrated that mild DNA replication stress
Devashish Dwivedi +2 more
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HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]
, 2001 Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson +33 more
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Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. [PDF]
PLoS ONE, 2011 Entry into and progression through mitosis depends on phosphorylation and dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal for exit from mitosis counteracting Cdk1-dependent phosphorylations.
Indra Tumurbaatar +4 more
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OLA1 is responsible for normal spindle assembly and SAC activation in mouse oocytes [PDF]
PeerJ, 2020 Background OLA1 is a member of the GTPase protein family; unlike other members, it possess both GTPase and ATPase activities, and can bind and hydrolyze ATP more efficiently than GTP.
Di Xie +4 more
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Asynchronous nuclear division cycles in multinucleated cells [PDF]
, 2006 Synchronous mitosis is common in multinucleated cells. We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii.
Gladfelter, A. S. +2 more
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BMC Research Notes, 2009 Background Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more varied.
Miller Anne +2 more
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A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends [PDF]
, 2015 The Astrin/SKAP complex plays important roles in mitotic chromosome alignment and centrosome integrity, but previous work found conflicting results for SKAP function.
Cheeseman, Iain M +3 more
core +1 more source
Origin of the Cones of the Multipolar Spindle in Gladiolus [PDF]
Botanical Gazette, 1900 The above observations may be summarized as follows: As nuclear division approaches, a granular zone accumulates about the nucleus. This zone in every respect resembles the perikaryoplasm so characteristic of the pollen mother cells of Cobaea. A close network or felted zone of kinoplasmic fibers is formed immediately outside of and completely ...
openaire +1 more source
Centrosome clustering and Cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors [PDF]
, 2010 Background: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tumor.
A Valent +50 more
core +5 more sources
Endosulfine alpha maintains spindle pole integrity by recruiting Aurora A during mitosis
BMC Cancer, 2023 Background The maintenance of spindle pole integrity is essential for spindle assembly and chromosome segregation during mitosis. However, the underlying mechanisms governing spindle pole integrity remain unclear.
Seul Kim +5 more
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