Results 81 to 90 of about 1,789 (148)
BMC Cell Biology, 2003 Background Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But,
Hiraoka Yasushi +6 more
doaj +1 more source
SHCBP1 is a novel regulator of PLK1 phosphorylation and promotes prostate cancer bone metastasis
MedComm, Volume 6, Issue 2, February 2025.Model for the interaction of SHCBP1 and PLK1. Schematics summarizing the interaction between SHCBP1 and PLK1, which promotes the Aurora A‐PLK1 interaction, leading to altered phosphorylation of PLK1 at T210, thus promoting cell mitosis and contributing to tumor development via the SHCBP1‐PLK1‐CDC25C axis. It also highlights the involvement of SHCBP1 in
Chen Tang +11 more
wiley +1 more source
Measuring and modeling polymer gradients argues that spindle microtubules regulate their own nucleation [PDF]
, 2017 Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation of microtubule nucleation remain poorly understood.
arxiv +1 more source
Neurodevelopmental Implications Underpinning Hereditary Spastic Paraplegia
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.Hereditary spastic paraplegia (HSP) is a group of rare genetic neurodegenerative disorders. This review comprehensively outlines the clinical manifestations, gene expression trajectories, and protein function of HSP subtypes from the perspective of neurodevelopment.
Yiqiang Zhi, Yan Shi, Danping Lu, Dan Xu
wiley +1 more source
c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin. [PDF]
PLoS ONE, 2012 In the present study, we demonstrated the cell cycle periodicity of Erbin expression with the maximal expression of Erbin in G2/M phase. A significant increase in Erbin promoter activity was observed in G2/M phase-synchronized cells.
Dan Liu +10 more
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arXiv, 2014 In this paper, spindle starshaped sets are introduced and investigated, which apart from normalization form an everywhere dense subfamily within the family of starshaped sets. We focus on proving spindle starshaped analogues of recent theorems of Bobylev, Breen, Toranzos, and Zamfirescu on starshaped sets.
arxiv
The mitotic spindle in the one-cell C. elegans embryo is positioned with high precision and stability [PDF]
, 2016 Precise positioning of the mitotic spindle is important for specifying the plane of cell division, which in turn determines how the cytoplasmic contents are partitioned into the daughter cells, and how the daughters are positioned within the tissue. During metaphase in the early C.
arxiv +1 more source
Optimal Hardy inequalities associated with multipolar Schrödinger operators [PDF]
arXiv, 2021 We proved some optimal Hardy inequalities in RNwhich is closely related to multipolar Schr\"odinger operators with mean-value type potentials, these sharp inequalities imply some multipolar type Heisenberg inequalities. We also obtained someimproved multipolar Hardy inequalities on bounded domains, moreover, we got the range of the best Hardy constant ...
arxiv
Developmental and tissue‐specific roles of mammalian centrosomes
The FEBS Journal, Volume 292, Issue 4, Page 709-726, February 2025.Centrosomes are dominant microtubule‐organizing centers in animal cells that are required for efficient mitoses to ensure normal embryonic development. Mammalian cells respond to centrosome loss‐of‐function by activating the mitotic surveillance pathway, a timing mechanism that leads to 53BP1‐, USP28‐, and p53‐dependent cell death or arrest when a ...
Charlotte Meyer‐Gerards, Hisham Bazzi
wiley +1 more source
On the role of p53 in the cellular response to aneuploidy
Cell Reports, 2021 Summary: Most solid tumors are aneuploid, and p53 has been implicated as the guardian of the euploid genome. Previous experiments using human cell lines showed that aneuploidy induction leads to p53 accumulation and p21-mediated G1 cell cycle arrest.
Akshay Narkar +9 more
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