Results 81 to 90 of about 147,555 (174)

Overexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosome

BMC Cell Biology, 2003
Background Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But,
Hiraoka Yasushi, Haraguchi Tokuko, Hori Takamitsu, Funakoshi Eishi, Kudoh Jun, Shimizu Nobuyoshi, Ito Fumiaki   +6 more
doaj   +1 more source

An Auxin Inducible Degradation System to Study Mklp2 Functions in MDCK Epithelial Cells

Biology of the Cell, Volume 117, Issue 6, June 2025.
This manuscript details the generation of an MDCK cell line in which the kinesin Mklp2 (KIF20A) is targeted at the endogenous level with an auxin inducible degradation (AID) tag and a GFP tag. This new tool facilitates the study of Mklp2 endogenous localization and constitutes a highly specific system for exploring Mklp2 functions at different stages ...
Morgane Rodriguez, Valérie Simon, Bénédicte Delaval, Benjamin Vitre   +3 more
wiley   +1 more source

Regenerating Locus Coeruleus‐Norepinephrine (LC‐NE) Function: A Novel Approach for Neurodegenerative Diseases

Cell Proliferation, Volume 58, Issue 6, June 2025.
The regeneration of LC‐NE from pluripotent stem cells (PSCs) could significantly mitigate the progression of Neurodegenerative diseases and alleviate associated psychiatric disease symptoms, providing a new approach to the treatment of neurological diseases.
Yana Yang, Yunlong Tao
wiley   +1 more source

Seasonal patterns of neurogenesis in European starlings (Sturnus vulgaris) are region‐ and sex‐specific

Journal of Neuroendocrinology, Volume 37, Issue 6, June 2025.
Abstract Songbird vocal behavior, physiology, and brains—including neurogenesis—change between seasons. We examined seasonal differences in neurogenesis in three brain regions associated with vocal production and learning, HVC (letter‐based proper name), robust nucleus of the arcopallium (RA), and Area X, and two brain regions associated with auditory ...
Sean D. T. Aitken, Broderick. M. B. Parks, Marjorie Sollows, Colleen A. Barber, Leslie S. Phillmore   +4 more
wiley   +1 more source

A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis

Frontiers in Oncology, 2011
Aurora-A is a serine/threonine kinase that plays critical roles in centrosome maturation, spindle dynamics and chromosome orientation and is frequently found overexpressed in human cancers.
Ignacio ePérez de Castro, Cristina eAguirre-Portolés, Benedicte eMartin, Gonzalo eFernández-Miranda, Andrea eKlotzbucher, Michael H. G. Kubbutat, Diego eMegías, Yannick eArlot-Bonnemains, Marcos eMalumbres   +8 more
doaj   +1 more source

An Indole Dearomatization Strategy for the Synthesis of Pseudo‐Natural Products

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
An indole‐dearomatization/reduction strategy is developed to expand a collection of indole‐containing pseudo‐NPs. This approach enhances the three‐dimensionality of the original compound classes through hybridization‐changing conversions leading to topologically distinct novel structures.
Joseph G. F. Hoock, Annina Burhop, Luca C. Greiner, Beate Schölermann, Celine Da Cruz Lopes Guita, Jie Liu, Sukdev Bag, Axel Pahl, Sonja Sievers, Rebecca Scheel, Carsten Strohmann, Slava Ziegler, Michael Grigalunas, Herbert Waldmann   +13 more
wiley   +1 more source

Neuronal diversity in the caudate nucleus: A comparative study between camel and human brains

The Anatomical Record, Volume 308, Issue 5, Page 1410-1424, May 2025.
Abstract Caudate nucleus (CN) neurons in camels and humans were examined using modified Golgi impregnation methods. Neurons were classified based on soma morphology, dendritic characteristics, and spine distribution. Three primary neuron types were identified in both species: rich‐spiny (Type I), sparsely‐spiny (Type II), and aspiny (Type III), each ...
Juman M. Almasaad, Ziad M. Bataineh, Sami Zaqout   +2 more
wiley   +1 more source

HN1 expression contributes to mitotic fidelity through Aurora A‐PLK1‐Eg5 axis

Cytoskeleton, Volume 82, Issue 5, Page 291-301, May 2025.
Abstract Hematological and neurological expressed 1 (HN1) is homolog of Jupiter protein from Drosophila melanogaster where it functions as a microtubule‐associated protein. However, in mammalian cells, HN1 is associated partially with y‐tubulin in centrosomes, Stathmin for stabilizing microtubules, and Cdh1 for regulating Cyclin B1 for cell cycle ...
Gülseren Özduman, Faruk Şimşek, Aadil Javed, Kemal Sami Korkmaz   +3 more
wiley   +1 more source

Targeting receptor for activated C kinase 1 with a small molecule induces mitotic catastrophe and suppresses lipid metabolic reprogramming in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
Longyan Wang, Peng Tan, Fei Wang, Huiming Huang, Xuejiao Wei, Zhuguo Wang, Xinyu Qiu, Yufeng Gao, Ruoxin Zhang, Pengfei Tu, Jun Li, Zhongdong Hu   +11 more
wiley   +1 more source

Age‐associated accumulation of RAB9 disrupts oocyte meiosis

Aging Cell, Volume 24, Issue 4, April 2025.
This study showed that RAB9 protein accumulates in old human and mouse oocytes. RAB9 accumulation disrupted spindle formation, chromosome alignment and actin cap formation, increased ROS levels, decreased mitochondrial membrane potential, ATP content, mtDNA/nDNA ratio and activated the PINK1‐PARKIN pathway. Importantly, knockdown of RAB9 in old oocytes
Min Gao, Fang Wang, Tengteng Xu, Yanling Qiu, Tianqi Cao, Simiao Liu, Wenlian Wu, Yitong Zhou, Haiying Liu, Fenghua Liu, Junjiu Huang   +10 more
wiley   +1 more source