Results 121 to 130 of about 73,884 (236)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Concatemer-assisted stoichiometry analysis: targeted mass spectrometry for protein quantification

Life Science Alliance
Concatemer-assisted stoichiometry analysis (CASA) addresses a common challenge in cell biology: absolute quantification of protein subunits in native protein complexes. Large multiprotein machines are central to many biological processes.
Jiaxi Cai, Yun Quan, Cindy Yuxuan Zhang, Ziyi Wang, Stephen M Hinshaw, Huilin Zhou, Raymond T Suhandynata   +6 more
doaj   +1 more source

A Multiprotein DNA Translocation Complex Directs Intramycelial Plasmid Spreading during Streptomyces Conjugation

mBio, 2015
Conjugative DNA transfer in mycelial Streptomyces is a unique process involving the transfer of a double-stranded plasmid from the donor into the recipient and the subsequent spreading of the transferred plasmid within the recipient mycelium.
Lina Thoma, Hyazinth Dobrowinski, Constanze Finger, Jamil Guezguez, Dirk Linke, Edgardo Sepulveda, Günther Muth   +6 more
doaj   +1 more source

Intracompartmental and Intercompartmental Transcriptional Networks Coordinate the Expression of Genes for Organellar Functions [PDF]

, 2011
Genes for mitochondrial and chloroplast proteins are distributed between the nuclear and organellar genomes. Organelle biogenesis and metabolism, therefore, require appropriate coordination of gene expression in the different compartments to ensure ...
Haberer, Georg, Kleine, Tatjana, Leister, Dario, Mayer, Klaus F. X., Wang, Xi   +4 more
core   +2 more sources

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation

Plant, Cell &Environment, EarlyView.
ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner, Fruzsina Vadai‐Nagy, Magdolna Gombos, Attila Hlacs, Eszter Molnár, Annamária Marton, Csaba Vizler, Rasik Shiekh Bin Hamid, Péter Kaló, Attila Fehér, Zoltán Magyar   +10 more
wiley   +1 more source

Architecture of the human mTORC2 core complex

eLife, 2018
The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2.
Edward Stuttfeld, Christopher HS Aylett, Stefan Imseng, Daniel Boehringer, Alain Scaiola, Evelyn Sauer, Michael N Hall, Timm Maier, Nenad Ban   +8 more
doaj   +1 more source

Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides [PDF]

, 2002
The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in ...
Coull, Jason J., Dervan, Peter B., He, Guocheng, Margolis, David M., Melander, Christian, Rucker, Victor C.   +5 more
core   +1 more source

Kinetochore size correlates with chromosome size in Star of Bethlehem (Ornithogalum kochii Parl., Asparagaceae)

Plant Biology, EarlyView.
Cytogenetic quantification of KNL1‐labelled kinetochores in Ornithogalum kochii reveals a significant positive scaling relationship between chromosome size and kinetochore size, demonstrating that chromosome–kinetochore scaling operates even across moderate intra‐karyotype size variation.
K. Panda, M. Hroneš, F. Zedek
wiley   +1 more source