Results 141 to 150 of about 73,884 (236)

Inflammasome — a new look at the therapy of cardiovascular diseases. Part II

Российский кардиологический журнал
The role of inflammasomes in cardiovascular diseases has not been sufficiently studied at present. However, there are a number of recent studies showing the participation of these multiprotein complexes in the development and progression of ...
A. A. Rubinstein, A. A. Khodot, P. V. Tirikova, A. S. Golovkin, I. V. Kudryavtsev, E. V. Shlyakhto   +5 more
doaj   +1 more source

Comparison of the Content of Several Elements in Seawater, Sea Cucumber Eupentacta fraudatrix and Its High-Molecular-Mass Multiprotein Complex. [PDF]

Molecules, 2022
Zaksas NP, Timofeeva AM, Dmitrenok PS, Soboleva SE, Nevinsky G.   +4 more
europepmc   +1 more source

Dissociating role of Bassoon in glutamatergic and dopaminergic neurons in alcohol‐related behaviour and affective state in mice

British Journal of Pharmacology, Volume 183, Issue 11, Page 3111-3128, June 2026.
Abstract Background and Purpose Alcohol abuse and affective disorders are severe comorbid psychiatric diseases characterized by impaired brain synaptic transmission. The role of presynaptic scaffolding proteins coordinating presynaptic plasticity and neurotransmitter release, such as Bassoon (Bsn), in the pathogenesis of these disorders remains elusive.
Liubov S. Kalinichenko, Mona Krenbauer, Janosh Isert, Marlon Kamlah, Thorben Tanzer, Hannes Rödel, Tobias Müller, Anil Annamneedi, Enes Yağız Akdaş, Volker Eulenburg, Bernd Lenz, Eckart D. Gundelfinger, Johannes Kornhuber, Anna Fejtova, Christian P. Müller   +14 more
wiley   +1 more source

The Role of Interferons in Inflammation and Inflammasome Activation

Frontiers in Immunology, 2017
Inflammation is an essential physiological process, which enables survival during infection and maintains tissue homeostasis. Interferons (IFNs) and pro- and anti-inflammatory cytokines are crucial for appropriate response to pathogens, damaged cells, or
Nataša Kopitar-Jerala
doaj   +1 more source

Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex. [PDF]

Nat Microbiol, 2021
Chicano TM, Dietrich L, de Almeida NM, Akram M, Hartmann E, Leidreiter F, Leopoldus D, Mueller M, Sánchez R, Nuijten GHL, Reimann J, Seifert KA, Schlichting I, van Niftrik L, Jetten MSM, Dietl A, Kartal B, Parey K, Barends TRM.   +18 more
europepmc   +1 more source

The “Tianyu” Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase‐1/GSDMD‐Mediated Pyroptosis Pathway

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Proposed signaling pathway by which TY modulates NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis. ABSTRACT This research focuses on exploring the modulation of pyroptosis and its underlying mechanisms via the “Tianyu” formulation (TY), a traditional Chinese medicine, in human rheumatoid arthritis fibroblast‐like synovial cells (RA‐HFLS) and a collagen ...
Yueya Zhu, Xinying Cai, Qiuhan Zheng, Chunqiu Fang, Zhi Pan, Yinghang Wang   +5 more
wiley   +1 more source

Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya

Cell Stress & Chaperones, 1998
In the oomycete fungus Achlya ambisexualis, hyphae of the male strain undergo sexual differentiation in the presence of the steroid hormone antheridiol. Earlier studies demonstrated that antheridiol binds with high affinity to a 9S multiprotein complex from A. ambisexualis cytosols.
S A, Brunt, G H, Perdew, D O, Toft, J C, Silver   +3 more
openaire   +3 more sources

Intercompartmental communication in senescence

FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social memory. [PDF]

Mol Psychiatry, 2021
Liu XD, Ai PH, Zhu XN, Pan YB, Halford MM, Henkemeyer M, Feng DF, Xu TL, Sun S, Xu NJ.   +9 more
europepmc   +1 more source

High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
We conducted a high‐throughput screen of 2747 FDA‐approved drugs to identify inhibitors of pyroptosis. We found that CeeNU significantly repressed NLRP3‐dependent IL‐1β release and GSDMD pore‐forming complex. We identified that the arginine 335 amino acid of the NACHT domain of NLRP3 is the critical point for human NLRP3 and CeeNU interaction and ...
Sen‐Lin Ji, Peipei Chen, Huaiping Tang, Chao Zhou, Zihao Li, Yunshu Wang, Xiang Cao, Liwen Zhu, Xinyu Bao, Zhuo Liu, Yan Chen, Yun Xu   +11 more
wiley   +1 more source