Results 61 to 70 of about 73,884 (236)

The photosystem I assembly apparatus consisting of Ycf3–Y3IP1 and Ycf4 modules

Nature Communications, 2018
Photosystem I is a large multiprotein complex embedded in the chloroplast thylakoid membrane. Here the authors provide evidence for a modular assembly process, whereby Ycf3 facilitates assembly of the reaction center, while Ycf4 incorporates peripheral ...
Sreedhar Nellaepalli, Shin-Ichiro Ozawa, Hiroshi Kuroda, Yuichiro Takahashi   +3 more
doaj   +1 more source

Single-Molecule Dynamics at a Bacterial Replication Fork after Nutritional Downshift or Chemically Induced Block in Replication

mSphere, 2021
All cells need to adjust DNA replication, which is achieved by a well-orchestrated multiprotein complex, in response to changes in physiological and environmental conditions.
Rogelio Hernández-Tamayo, Hannah Schmitz, Peter L. Graumann   +2 more
doaj   +1 more source

An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma [PDF]

, 2016
The conserved Myb-MuvB (MMB) multiprotein complex has an important role in transcriptional activation of mitotic genes. MMB target genes are overexpressed in several different cancer types and their elevated expression is associated with an advanced ...
Francke, S., Garcia, P., Gaubatz, S., Hauser, S., Iltzsche, F., Murphy, D.J., Pattschull, G., Rosenwald, A., Simon, K., Stopp, S., Wolter, P.   +10 more
core   +2 more sources

The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis

Nature Communications, 2020
Mediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the ...
Qikun Liu, Sylvain Bischof, C. Jake Harris, Zhenhui Zhong, Lingyu Zhan, Calvin Nguyen, Andrew Rashoff, William D. Barshop, Fei Sun, Suhua Feng, Magdalena Potok, Javier Gallego-Bartolome, Jixian Zhai, James A. Wohlschlegel, Michael F. Carey, Jeffrey A. Long, Steven E. Jacobsen   +16 more
doaj   +1 more source

The trigger for pancreatic disease: NLRP3 inflammasome

Cell Death Discovery, 2023
NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an ...
Tianming Liu, Qiang Wang, Zhiwei Du, Lu Yin, Jiachen Li, Xianzhi Meng, Dongbo Xue   +6 more
doaj   +1 more source

Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]

, 2004
Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Gottgens, Berthold, Heil, Matthias, Huss, Ralf, Kinston, Sarah, Moosmann, Sabine, Sagebiel, Sabine, Seliger, Christian, Ziegelhoeffer, Tibor   +7 more
core   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer

Life, 2022
The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and medulloblastoma.
Fan Yang, Daniel T. Wynn, Chen Shen, Nagi G. Ayad, David J. Robbins   +4 more
openaire   +3 more sources

A Molecular Basis for Stabilization of the von Hippel-Lindau (VHL) Tumor Suppressor Protein by Components of the VHL Ubiquitin Ligase [PDF]

, 2002
The multiprotein von Hippel-Lindau (VHL) tumor suppressor (CBCVHL, Cul2-Elongin BC-VHL) and SCF (Skp1-Cul1/Cdc53-F-box protein) complexes are members of structurally related families of E3 ubiquitin ligases that use a heterodimeric module composed of a ...
Brower, Christopher S., Conaway, Joan W., Conaway, Ronald C., Kamura, Takumi   +3 more
core   +2 more sources

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source