Results 91 to 100 of about 40,419 (211)

Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex during Red Blood Cell Invasion by Plasmodium falciparum Merozoites

mBio, 2020
Red blood cell (RBC) invasion by Plasmodium merozoites requires multiple steps that are regulated by signaling pathways. Exposure of P. falciparum merozoites to the physiological signal of low K+, as found in blood plasma, leads to a rise in cytosolic ...
Kunal R. More, Inderjeet Kaur, Quentin Giai Gianetto, Brandon M. Invergo, Thibault Chaze, Ravi Jain, Christéle Huon, Petra Gutenbrunner, Hendrik Weisser, Mariette Matondo, Jyoti S. Choudhary, Gordon Langsley, Shailja Singh, Chetan E. Chitnis   +13 more
doaj   +1 more source

Penicillin and Beyond: Evolution, Protein Fold, Multimodular Polypeptides, and Multiprotein Complexes [PDF]

, 1996
peer reviewedAs the protein sequence and structure databases expand, the relationships between proteins, the notion of protein superfamily, and the driving forces of evolution are better understood.
Fonze, Eveline, Joris, Bernard, Ghuysen, Jean-Marie, Duez, Colette, Charlier, Paulette, Fraipont, Claudine, Goffin, Colette, Coyette, Jacques, Nguyen-Distèche, Martine   +8 more
core   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Single-molecule visualization of fast polymerase turnover in the bacterial replisome

eLife, 2017
The Escherichia coli DNA replication machinery has been used as a road map to uncover design rules that enable DNA duplication with high efficiency and fidelity.
Jacob S Lewis, Lisanne M Spenkelink, Slobodan Jergic, Elizabeth A Wood, Enrico Monachino, Nicholas P Horan, Karl E Duderstadt, Michael M Cox, Andrew Robinson, Nicholas E Dixon, Antoine M van Oijen   +10 more
doaj   +1 more source

Robots, pipelines, polyproteins:enabling multiprotein expression in prokaryotic and eukaryotic cells

, 2011
Multiprotein complexes catalyze vital biological functions in the cell. A paramount objective of the SPINE2 project was to address the structural molecular biology of these multiprotein complexes, by enlisting and developing enabling technologies for ...
Arnaud Poterszman, Frederic Garzoni, Lakshmi Sumitra Vijayachandran, Poterszman, Arnaud, Romier, Christophe, Christoph Bieniossek, Christophe Romier, Busso, Didier, Timothy J. Richmond, Bieniossek, Christoph, Chaillet, Maxime, Didier Busso, Garzoni, Frederic, Richmond, Timothy J, Schaffitzel, Christiane, Berger, Imre, Richmond, Timothy, Cristina Viola, Simon Trowitzsch, Christiane Schaffitzel, Maxime Chaillet, Trowitzsch, Simon, Viola, Cristina, Imre Berger, Vijayachandran, Lakshmi Sumitra   +24 more
core   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

eLife, 2019
Coordination of the cellular response to DNA damage is organised by multi-domain ‘scaffold’ proteins, including 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other proteins ...
Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver, Laurence H Pearl   +5 more
doaj   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Architecture of the human mTORC2 core complex

eLife, 2018
The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2.
Edward Stuttfeld, Christopher HS Aylett, Stefan Imseng, Daniel Boehringer, Alain Scaiola, Evelyn Sauer, Michael N Hall, Timm Maier, Nenad Ban   +8 more
doaj   +1 more source