Results 101 to 110 of about 960,142 (193)

Multiprotein complex production in E. coli:the SecYEG-SecDFYajC-YidC Holotranslocon [PDF]

, 2017
A modular approach for balanced overexpression of recombinant multiprotein complexes in E. coli is described, with the prokaryotic protein secretase/insertase complex, the SecYEG-SecDFYajC-YidC holotranslocon (HTL), used as an example. This procedure has
Jiang, Quiyang, Ryan J. Schulze, Ian Collinson, Schaffitzel, Christiane, Imre Berger, Schulze, Ryan, Quiyang Jiang, Collinson, Ian, Berger, Imre, Christiane Schaffitzel   +9 more
core   +1 more source

Microbiome‐Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The graphical abstract illustrates how microbiome‐derived indoles activate the aryl hydrocarbon receptor to restore the intestinal barrier. The picture contrasts the “leaky gut” state with the restored homeostasis achieved through AMPK, Nrf2, and IL‐22 signaling.
Mohammad Ali Mahdiabadi, Asma Moghaddam, Nafiseh Erfanian   +2 more
wiley   +1 more source

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

Journal of Immunology Research, 2016
Inflammasomes are multiprotein complexes that trigger the activation of caspases-1 and subsequently the maturation of proinflammatory cytokines interleukin-1β and interleukin-18.
Keren Zhou, Ligen Shi, Yan Wang, Sheng Chen, Jianmin Zhang   +4 more
doaj   +1 more source

HR-Bac, a toolbox based on homologous recombination for expression, screening and production of multiprotein complexes using the baculovirus expression system. [PDF]

Sci Rep, 2022
Kolesnikova O, Zachayus A, Pichard S, Osz J, Rochel N, Rossolillo P, Kolb-Cheynel I, Troffer-Charlier N, Compe E, Bensaude O, Berger I, Poterszman A.   +11 more
europepmc   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Inflammasome — a new look at the therapy of cardiovascular diseases. Part II

Российский кардиологический журнал
The role of inflammasomes in cardiovascular diseases has not been sufficiently studied at present. However, there are a number of recent studies showing the participation of these multiprotein complexes in the development and progression of ...
A. A. Rubinstein, A. A. Khodot, P. V. Tirikova, A. S. Golovkin, I. V. Kudryavtsev, E. V. Shlyakhto   +5 more
doaj   +1 more source

Author Correction: HR-Bac, a toolbox based on homologous recombination for expression, screening and production of multiprotein complexes using the baculovirus expression system. [PDF]

Sci Rep, 2022
Kolesnikova O, Zachayus A, Pichard S, Osz J, Rochel N, Rossolillo P, Kolb-Cheynel I, Troffer-Charlier N, Compe E, Bensaude O, Berger I, Poterszman A.   +11 more
europepmc   +1 more source

Two distinct alcohol dehydrogenase classes mediate bacterial 2‐hydroxyethylphosphonate catabolism

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Phosphonates are molecules containing a direct carbon‐phosphorus bond. In nature, these compounds are produced by a variety of organisms, and many environmental microbes are able to degrade specific phosphonates and feed on them. This work focuses on 2‐hydroxyethylphosphonate (HEP)—a natural compound that is found frequently in the environment,
Francesca Piazza, Marianna Rodella, Nicholas Salanti, Giovanni Merici, Elisa Rossi, Claudio Rivetti, Florian Götzinger, Katharina Pallitsch, Alessio Peracchi   +8 more
wiley   +1 more source

Engineering a protein homodimer from a heterodimer: A chimeric DBHS protein

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Drosophila behavior/human splicing (DBHS) proteins are involved at nearly every stage of the RNA lifecycle. There are three paralogues in mammals—SFPQ, NONO and PSPC1—which form both homodimer and heterodimers. It is likely that the non‐redundant and overlapping roles of the different DBHS paralogues emerge from their dynamic and combinatorial
Andrew C. Marshall, Isabelle Mohnen, Alejandro Villa Gomez, Archa H. Fox, Gavin J. Knott, Charles S. Bond   +5 more
wiley   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, Volume 41, Issue 10, Page 1105-1118, October 2026.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source