Results 121 to 130 of about 960,142 (193)

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Tectum opticum development in embryonic quail (Coturnix japonica) and the role of HSP70 in the developmental process

Journal of Veterinary Research
The tectum opticum, which is a section of the mesencephalon, is located between the cerebellum and the ventral hemispherium of birds. In birds, the tectum opticum has a well-developed, thick, layered structure.
Ermutlu Dilem Gülece, Aksu Serap İlhan, Deprem Turgay, Taşçi Serap Koral, Aslan Şahin, Aslan Rumeysa Nur   +5 more
doaj   +1 more source

Polycystins as components of large multiprotein complexes of polycystin interactors. [PDF]

Cell Signal, 2020
Hardy E, Tsiokas L.
europepmc   +1 more source

Atmospheric Aerosol Neurotoxicity and Parkinson's Disease: Mechanisms and Perspectives

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Schematic overview of the pathways and pathological mechanisms connecting atmospheric aerosol exposure to PD. Atmospheric aerosols, including PM2.5 and nanometer/ultrafine particles loaded with metal particles, persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and dioxins, enter the body predominantly via pulmonary ...
Yitian Gao, Minxiang Dong, Chenyang Duan, Xiaohan Zheng, Liming Qu   +4 more
wiley   +1 more source

RBMX Transcriptionally Repressed by EZH2‐Associated H3K27me3 Modification Attenuates Pyroptosis in Renal Ischemia/Reperfusion Injury via Regulating SIRT3/NLRP3 Inflammasome Activation

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Ischemic reperfusion injury (IRI) to kidney is a significant clinical factor in acute kidney injury (AKI). This study aimed to investigate the new role of RNA‐binding motif protein X‐linked (RBMX), a modulator of m6A methylation, in renal IRI and to examine the associated regulatory mechanisms. An in vitro renal IRI model was established using
Yi‐Han Wang, Yan Teng, Fang‐Lan Yao, Shu‐Qi Wei, Yan Li   +4 more
wiley   +1 more source

Multi-Protein Complexes Studied by Mass Spectrometry

The Scientific World Journal, 2002
Jens S. Andersen, Juri Rappsilber, Hanno Steen, Akhilesh Pandey, Henrik Molina, Michael Lund, Alexandre Podtelejnikov, Angus I. Lamond, Matthias Mann   +8 more
doaj   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

METTL3‐Mediated N6‐Methyladenosine Modification Activates the EGR1‐ZBP1 Axis to Promote PANoptosis‐Like Cardiomyocyte Death in Myocardial Ischemia‐Reperfusion Injury

MedComm, Volume 7, Issue 9, September 2026.
Myocardial ischemia‐reperfusion injury promotes lactate accumulation and H3K18 lactylation at the Mettl3 promoter, inducing METTL3 expression in cardiomyocytes. METTL3 installs m6A on Egr1 mRNA, enhancing EGR1 expression via YTHDF1‐mediated translation and IGF2BP2‐dependent stabilization.
Linnan Li, Jinfeng Gao, Xiaoxue Zhang, Kunming Dai, Hao Cheng, Jianying Ma, Junbo Ge   +6 more
wiley   +1 more source

Integrative Phytochemical, Antioxidant, and NLRP3‐Linked and Anti‐Inflammatory Evaluation of Salvia balansae (Aurès Chemotype): Insights Into Its Safety and Therapeutic Potential

ChemistryOpen, Volume 15, Issue 9, September 2026.
An endemic Aurès chemotype of Salvia balansae emerges as a rich source of luteolin, rosmarinic acid, and other polyphenols with potent antioxidant and NLRP3‐linked anti‐inflammatory activities. Protection against experimental inflammation, favorable enzyme‐modulating properties, and a wide safety margin highlight its promise as a pharmaceutical and ...
Khadra Afaf Bendrihem, Messaoud Hachemi, Mohamed Aimene Mihoubi, Fares Mohamed Amine, Majid Sharifi‐Rad, Dalal Houhou, Rahma Guemmaz, Khaled Kherraz, Azzeddine Zeraib, Assia Abdelmalek, Aicha Mouane, Nour Elhouda Ayeb, Chawki Bensuici, Maria Chikha, Kamel Nagaz, Ayomide Victor Atoki, Mohammed Messaoudi   +16 more
wiley   +1 more source