Results 111 to 120 of about 960,142 (193)

PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4⁺ T Cells. [PDF]

Front Immunol, 2021
Luff DH, Wojdyla K, Oxley D, Chessa T, Hudson K, Hawkins PT, Stephens LR, Barry ST, Okkenhaug K.   +8 more
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Stepwise order in protein complex assembly: approaches and emerging themes

Open Biology
Protein-based nanomachines drive every cellular process. An explosion of high-resolution structures of multiprotein complexes has improved our understanding of what these machines look like and how they work, but we still know relatively little about how
Michael T. Brown, Michael A. McMurray
doaj   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, Volume 13, Issue 53, 24 September 2026.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Co-translational assembly pathways of nuclear multiprotein complexes involved in the regulation of gene transcription

International audienceMost factors that regulate gene transcription in eukaryotic cells are multimeric, often large, protein complexes. The understanding of the biogenesis pathways of such large and heterogeneous protein assemblies, as well as the ...
Andrea Bernardini, László Tora, Tora, László, Bernardini, Andrea   +3 more
core   +1 more source

The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Synaptic dysfunction is an early feature of Alzheimer's disease (AD) and proper localization of proteins involved in pre‐ and post‐synaptic composition is dependent on endosomal recycling and trafficking, cellular processes involving the AD risk gene sortilin‐related receptor 1 (SORL1). METHODS We examined SORL1's role in synaptic
C. Andrew Williams, Shannon E. Rose, Vera Stamenkovic, Aquene N. Reid, Kyle J. Travaglini, Stephen E. P. Smith, Jessica E. Young   +6 more
wiley   +1 more source

Anti‐Inflammatory Activity of Capparis cartilaginea Decne. Essential Oil and Its Main Constituents via Modulation of the NLRP3 Inflammasome

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
C. cartilaginea essential oil and its major constituents exhibited marked anti‐inflammatory activity in LPS‐stimulated THP‐1 macrophages by reducing pro‐inflammatory cytokine and nitric oxide production. These effects were associated with inhibition of NLRP3 inflammasome activation and MAPK signalling, providing mechanistic evidence to support the anti‐
Bashaer Alsharif, Nadhim Hante, María Jose Santos‐Martínez, Fabio Boylan   +3 more
wiley   +1 more source

Fucoxanthin Attenuates Hepatic Damage in a d‐Galactose‐Induced Accelerated Aging Mouse Model: Insight Into Underlying Mechanisms

Food Frontiers, Volume 7, Issue 5, September 2026.
Fucoxanthin alleviates d‐galactose‐induced hepatic damage by reducing oxidative stress, inflammation, and multiple programmed cell death pathways. ABSTRACT The global population is aging rapidly, and aging‐related hepatic damage poses a significant public health challenge.
Han‐Ni Wei, Cheng‐Yu Yang, Hui Li, Shi‐Xiang Wu, Qing‐Yan Zou, Yan Zheng, Kazuo Miyashita, Yu‐Hong Yang, Lei Du   +8 more
wiley   +1 more source

TSG From Polygonum multiflorum Thunb. Attenuates Experimental Premature Ovarian Insufficiency in Association With Reduced ZBP1/PANoptosis Signaling

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study shows that TSG, the major bioactive constituent of Polygonum multiflorum Thunb., ameliorates POI in association with suppression of ZBP1‐driven PANoptosis. In a POI rat model, TSG restored estrous cyclicity, improved hormone profiles, and preserved follicular reserve.
Jinhong Li, Tiao Xie, Chang Lin, Danhong Peng, Qin Shi, Can Zhu   +5 more
wiley   +1 more source

Knee Osteoarthritis Therapy Targeting NLRP3 Inflammasome: Progress From Mechanism to Application

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This paper briefly reviews the structure, function, and activation mechanism of the NLRP3 inflammasome and its molecular role in the pathogenesis of knee osteoarthritis (KOA), and explores the potential value of traditional Chinese medicine (TCM) in treating KOA by modulating NLRP3 inflammasome activity.
Wenguang Chen, Baoxiu Yi, Zhang Wang, Cong Yu, Ziru Li, Zenan Wu, Ensi Hong   +6 more
wiley   +1 more source