Results 241 to 250 of about 61,024 (262)
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ACEMBLing a Multiprotein Transmembrane Complex
Nature Methods, 2015Structural and functional studies of many multiprotein complexes depend on recombinant-protein overexpression. Rapid revision of expression experiments and diversification of the complexes are often crucial for success of these projects; therefore, automation is increasingly indispensable.
Joanna Komar +4 more
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Multiprotein complex signaling and the plasticity problem
Current Opinion in Neurobiology, 2001Synaptic transmission of distinct patterns of spikes, or 'neural code', leads to plastic changes in synapses and other parts of the neuron, as well as learning in animals. Recent findings indicate that specialized multiprotein structures associated with neurotransmitter receptors and cell-adhesion proteins function as molecular devices that both read ...
S G, Grant, T J, O'Dell
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The centrosome is a polyfunctional multiprotein cell complex
Biochemistry (Moscow), 2008Contemporary knowledge about centrosome proteins and their ensembles, which can be divided into several functional groups--microtubule-nucleating proteins, microtubule-anchoring proteins, centriole-duplication proteins, cell cycle control proteins, primary cilia growth regulation proteins, and proteins of regulation of cytokinesis--is reviewed ...
I B, Alieva, R E, Uzbekov
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Biochemistry of Multiprotein HDAC Complexes
2006Histone deacetylases perform an important role in the regulation of transcription by modifying the histone components of chromatin. This imparts specific restrictions to transcription and contributes to the proper coordination of gene expression. In order to perform these functions and to achieve proper modulation of their activity, HDACs associate ...
Alejandro Vaquero +2 more
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Protein- and immunoaffinity purification of multiprotein complexes
2002Publisher Summary This chapter discusses the protein and immunoaffinity purification of multiprotein complexes. Virtually all proteins must interact with other proteins to carry out their activities within the cell. Protein affinity chromatography allows the exploitation of this fundamental property to identify proteins that function together as ...
Douglas R, Kellogg, Danesh, Moazed
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Multiprotein signaling complexes and regulation of cardiac phenotype
Journal of Molecular and Cellular Cardiology, 2003There is increasing evidence across disciplines for multiprotein complexes as a mechanism for signal transduction in various cell types. These multiprotein complexes appear to be altered as a direct mechanism to confer signaling responses and to alter phenotype. Although classical experimental techniques are effective to delineate the signaling role of
Thomas M, Vondriska, Peipei, Ping
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Catalysis by a Multiprotein IκB Kinase Complex
Science, 1997Many extracellular signals, tumor necrosis factor-a and interleukin-1 among them, transmit their signals to the genetic apparatus via the transcriptional activator, NF-kB. Maniatis summarizes what is known about this critical pathway and describes how two reports in this issue ([ Mercurio et al .][1] and [ Woronicz et al .][2]) add to the story. [1]:
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Multiprotein signalling complexes: regional assembly on heparan sulphate
Biochemical Society Transactions, 2006Heparan sulphate (HS) is an abundant component of cell surfaces and the extracellular matrix. It binds to a wide variety of peptide growth factors, morphogens, chemokines and extracellular matrix proteins (e.g. fibronectin) and many of these interactions are essential for these effector proteins to transduce signals across the plasma membrane.
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Mapping multiprotein complexes by affinity purification and mass spectrometry
Current Opinion in Biotechnology, 2008The combination of affinity purification and tandem mass spectrometry (MS) has emerged as a powerful approach to delineate biological processes. In particular, the use of epitope tags has allowed this approach to become scaleable and has bypassed difficulties associated with generation of antibodies. Single epitope tags and tandem affinity purification
Mark O, Collins, Jyoti S, Choudhary
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The Propagation of Allosteric States in Large Multiprotein Complexes
Journal of Molecular Biology, 2013A statistical view of allostery leads to a more nuanced and physically realistic picture of protein cooperativity. If the conformational state of one protein molecule in a multiprotein complex influences the probability of a particular conformation in a neighbouring protein, then changes can propagate.
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