Results 111 to 120 of about 19,858 (239)

Parthenolide Attenuates Skeletal Muscle Atrophy Through Regulation of Protein Homeostasis and Inhibition of Inflammation

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Parthenolide attenuates skeletal muscle atrophy through coordinated regulation of protein homeostasis and inflammatory signaling. It counteracts TNF‐α‐mediated inhibition of AKT signaling, thereby restoring AKT–mTOR activation to promote protein synthesis and suppress protein degradation through inhibition of the FoxO transcription factors, which ...
Yu Bai, Weiqing Li, Yahong Lu, Hehuan Lai, Lin Ye, Kechi Li, Chendi Wang, Yi Ding, Wenhao Li, Yitao Chen, Keping Gan, Zhenzhong Chen, Dengwei He   +12 more
wiley   +1 more source

A Dynamic Multitarget Obstacle Tracking and Monitoring Method for Vehicle Routing Based on Multiple Constraint Composite Perception Association Filtering

IEEE Access
Multitarget tracking technology is the core topic in the field of intelligent driving. Multi-target complex manoeuvring, measurement outliers and unknown environmental prior parameters strongly affect the tracking accuracy of the target state. To address
Guoxin Han, Fuyun Liu, Huiqi Liu, Jucai Deng, Weihua Bai, Keqin Li   +5 more
doaj   +1 more source

P2‐053: DESIGNING AND VALIDATION OF NOVEL THERAPEUTIC‐METHYLATED PEPTIDE INHIBITORS AS MULTITARGET DRUG FOR CANCER ASSOCIATED ALZHEIMER'S DISEASE [PDF]

, 2019
Lokesh Thangamani, Murugesh Easwaran, Shanmughavel Piramanayagam, Arun Meyyazhagan   +3 more
openalex   +1 more source

Combined inhibition of atrial‐specific potassium currents as a possible anti‐arrhythmic drug therapy: A match made in silico

The Journal of Physiology, EarlyView.
Vladimír Sobota
wiley   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Mechanism and Molecular Design Principles of Cationic Surfactants: From Charge‐Driven Membrane Interactions to Next‐Generation Quaternary Ammonium Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Within this review we provide an overview of the social relevance of quaternary ammonium surfactants, different classes of these agents, their interaction mechanism with cellular membranes, structure activity relation, bacterial resistance toward these systems and new approaches to guarantee their long‐term efficiency.
Natalie Hanheiser, Yuhang Jiang, Chuanxiong Nie, Rainer Haag   +3 more
wiley   +1 more source

Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents

, 2017
Ehtesham Jameel, Poonam Meena, Mudasir Maqbool, Jitendra Kumar, Waqar Ahmed, Syed Mumtazuddin, Manisha Tiwari, Nasimul Hoda, B. Jayaram   +8 more
openalex   +1 more source

Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer’s disease

, 2020
Dorota Łażewska, Marek Bajda, Maria Kaleta, Paula Zaręba, Agata Doroż-Płonka, Agata Siwek, Alaa Alachkar, Szczepan Mogilski, Ali Saad, Kamil Kuder, Agnieszka Olejarz‐Maciej, Justyna Godyń, Dorota Stary, Sylwia Sudoł, Małgorzata Więcek, Gniewomir Latacz, Maria Walczak, Jadwiga Handzlik, Bassem Sadek, Barbara Malawska, Katarzyna Kieć‐Kononowicz   +20 more
openalex   +2 more sources

A Novel Nonlinear Multitargetk-Degree Coverage Preservation Protocol in Wireless Sensor Networks [PDF]

, 2016
Zeyu Sun, Xiaofei Xing, Chuanfeng Li, Yalin Nie, Yangjie Cao   +4 more
openalex   +1 more source

multitarget-directed ligand

Citation: 'multitarget-directed ligand' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12687 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source