Results 61 to 70 of about 19,858 (239)

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Multifunctional Cinnamic Acid Derivatives

Molecules, 2017
Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino) ethan-1-ol.
Aikaterini Peperidou, Eleni Pontiki, Dimitra Hadjipavlou-Litina, Efstathia Voulgari, Konstantinos Avgoustakis   +4 more
doaj   +1 more source

Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by Docking Studies [PDF]

, 2023
Ahmed K. B. Aljohani, Waheed Ali Zaki El Zaloa, Mohamed Alswah, Mohamed A. Seleem, Mohamed M. Elsebaei, Ashraf H. Bayoumi, Ahmed El-morsy, Mohammed Almaghrabi, Aeshah A. Awaji, Ali Hammad, Marwa Alsulaimany, Hany E. A. Ahmed   +11 more
openalex   +1 more source

RT‐DETR‐DA for Complex Scenes: Distracted Driving Detection With Feature Interaction and Dynamic Perception

Advanced Intelligent Systems, EarlyView.
This work proposes RT‐DETR‐DA, an enhanced real‐time detection framework for identifying distracted driving in complex, real‐world environments. The model introduces a dynamic sparse gating multiscale attention module and an attention‐guided dual‐path fusion module to strengthen multiscale perception and cross‐layer feature interaction.
Yi Liu, QiaoXing Li, XiBin Wang, Ying He, Sen Zhang   +4 more
wiley   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Discovery of Multitarget-Directed Ligands Against Influenza A Virus From Compound Yizhihao Through a Predictive System for Compound-Protein Interactions

Frontiers in Cellular and Infection Microbiology, 2020
Influenza A virus (IAV) is a threat to public health due to its high mutation rate and resistance to existing drugs. In this investigation, 15 targets selected from an influenza virus–host interaction network were successfully constructed as a ...
Lvjie Xu, Wen Jiang, Hao Jia, Lishu Zheng, Jianguo Xing, Ailin Liu, Guanhua Du   +6 more
doaj   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

In Silico Studies on Compounds Derived from Calceolaria: Phenylethanoid Glycosides as Potential Multitarget Inhibitors for the Development of Pesticides

Biomolecules, 2018
An increasing occurrence of resistance in insect pests and high mammal toxicity exhibited by common pesticides increase the need for new alternative molecules.
Marco A. Loza-Mejía, Juan Rodrigo Salazar, Juan Francisco Sánchez-Tejeda   +2 more
doaj   +1 more source

Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies [PDF]

, 2021
Celia Martín-Beltrán, Raquel Gil-Edo, Germán Hernández-Ribelles, Raül Agut, Pilar Marí-Mezquita, Miguel Cardá, Eva Falomir   +6 more
openalex   +1 more source

Mechanism of Hydrogen Sulfide Generation and Prevention Strategies in Oil and Gas Fields: A Case Study of the Sickle Bay Operation Area

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT To address the persistent exceedance of hydrogen sulfide (H2S) concentrations and the limited effectiveness of existing treatments in the Sickle Bay oil production area, this study deeply analyzes the mechanism of H2S generation in the Sickle Bay oil production area and proposes targeted prevention and control strategies. The results show that
Bo Lei, Yao‐long Li, Bao‐ping Bai, Xiang‐de Zhang, Guan‐tao Shi, Yong‐long Xie, Chen‐xiao Hou, Cong‐Yu Ke   +7 more
wiley   +1 more source