Results 81 to 90 of about 19,858 (239)
Molecular Carcinogenesis, EarlyView.ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao +6 more
wiley +1 more source
Sulfonamides a Promising Hit for Cancer Therapy Through VEGFR-2 Inhibition
BiomedicinesVascular endothelial growth factor receptor-2 (VEGFR-2), a tyrosine kinase receptor (TKR), plays a crucial role in angiogenesis and is overexpressed in most cancers.
Eleftherios Charissopoulos +1 more
doaj +1 more source
ChemistryOpen, EarlyView.Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali +4 more
wiley +1 more source
From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies
Portal Hypertension &Cirrhosis, EarlyView.This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu +5 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Chronic atrophic gastritis (CAG), a widespread gastrointestinal condition, is widely acknowledged as a precursor to gastric cancer (GC). The incidence of CAG has been steadily increasing, yet effective pharmacological interventions remain unavailable. Asiatic acid (AA), a bioactive triterpenoid isolated from Centella asiatica, has demonstrated
Feifei Zhou +9 more
wiley +1 more source
Phytotherapy Research, EarlyView.Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta +7 more
wiley +1 more source
Duloxetine, a Multitarget Drug [PDF]
Advances in Pharmacoepidemiology & Drug Safety, 2012 This review presents an overview of the multi targets of the duloxetine drug which was a product of the famous Eli Lilly Company. Although there is little evidence that the studies reproduce, it is clear that different transmitters or receptor types are involved in hyperalgesia and chronic pain which duloxetine mainly targets.
openaire +1 more source
Netrin-1 as a Multitarget Barrier Stabilizer in the Peripheral Nerve after Injury [PDF]
, 2021 Jeremy Tsung-Chieh Chen +5 more
openalex +1 more source
Phytotherapy Research, EarlyView.Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou +9 more
wiley +1 more source