Results 41 to 50 of about 13,574 (319)
Multivalent Glycocalixarenes [PDF]
, 2011 Calixarenes, the cyclic oligomers obtained by condensation of phenols or resorcinols with aldehydes, are ideal scaffolds for the construction of multivalent glycosylated ligands with unique properties. Thanks to the possibility that we can vary their size, valency and conformation and finely tune the topology of the saccharide units in the space, a ...
SANSONE, Francesco +3 more
openaire +2 more sources
Clicked and long spaced galactosyl- and lactosylcalix[4]arenes: new multivalent galectin-3 ligands
Beilstein Journal of Organic Chemistry, 2014 Four novel calix[4]arene-based glycoclusters were synthesized by conjugating the saccharide units to the macrocyclic scaffold using the CuAAC reaction and using long and hydrophilic ethylene glycol spacers.
Silvia Bernardi +6 more
doaj +1 more source
Molecules, 2021 Synthesis of tetravalent thio- and selenogalactopyranoside-containing glycoclusters using azide-alkyne click strategy is presented. Prepared compounds are potential ligands of Pseudomonas aeruginosa lectin PA-IL. P.
Tünde Zita Illyés +8 more
doaj +1 more source
Biophysical regulation of stem cell behavior within the niche. [PDF]
, 2012 Stem cells reside within most tissues throughout the lifetimes of mammalian organisms. To maintain their capacities for division and differentiation and thereby build, maintain, and regenerate organ structure and function, these cells require extensive ...
Conway, Anthony, Schaffer, David V
core +1 more source
Influence of length and flexibility of spacers on the binding affinity of divalent ligands
Beilstein Journal of Organic Chemistry, 2015 We present a quantitative model for the binding of divalent ligand–receptor systems. We study the influence of length and flexibility of the spacers on the overall binding affinity and derive general rules for the optimal ligand design.
Susanne Liese, Roland R. Netz
doaj +1 more source
Selective Integrin α5β1 Targeting through Spatially Constrained Multivalent DNA-Based Nanoparticles
Molecules, 2022 Targeting cells specifically based on receptor expression levels remains an area of active research to date. Selective binding of receptors cannot be achieved by increasing the individual binding strength, as this does not account for differing ...
Eva E. Kurisinkal +4 more
doaj +1 more source
, 2019 In this work, we present a bottom-up approach for the synthesis of lactose-functionalized glycomacromolecules and glycofunctionalized liposomes and apply these compounds to investigate their effects of multivalent presentation on binding to galectin-3 ...
Elling, L. +9 more
core +1 more source
Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores
Beilstein Journal of Organic Chemistry, 2014 Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and ...
Mathieu L. Lepage +6 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2020 Bisimidazolium receptors, tagged with chromophoric pyrene at one end and linked to an n-alkyl chain at the other, underwent self-assembly in aqueous media depending on the length of the alkyl segment.
Rakesh Biswas +3 more
doaj +1 more source
Evaluation of multivalency as an organization principle for the efficient synthesis of doubly and triply threaded amide rotaxanes [PDF]
, 2014 Mono-, di- and trivalent pseudorotaxanes with tetralactam macrocycle hosts and axles containing diamide binding stations as the guests have been synthesised.
Kaufmann, Lena +6 more
core +1 more source