Brucella Egresses from Host Cells Exploiting Multivesicular Bodies [PDF]
mBio, 2023 Host cell egress is a critical step in the life cycle of intracellular pathogens, especially in microbes capable of establishing chronic infections. The Gram-negative bacterium Brucella belongs to such a group of pathogens. Even though much has been done
Juan Manuel Spera +3 more
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Biogenesis and Function of Multivesicular Bodies in Plant Immunity [PDF]
Frontiers in Plant Science, 2018 Multivesicular bodies (MVBs) are specialized endosomes that contain intraluminal vesicles generated from invagination and budding of the limiting membrane.
Xifeng Li +8 more
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Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling [PDF]
eLife, 2018 The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye +2 more
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Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles [PDF]
Journal of Extracellular Vesicles, 2021 Multivesicular bodies (MVBs) fuse with not only the plasma membranes to release extracellular vesicles (EVs) but also lysosomes for degradation. Rab7 participates in the lysosomal targeting of MVBs.
Xuefeng Fei +14 more
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Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]
PLoS Pathogens, 2019 Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Jennifer R Linden +7 more
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Inclusion biogenesis and reactivation of persistent Chlamydia trachomatis requires host cell sphingolipid biosynthesis. [PDF]
PLoS Pathogens, 2009 Chlamydiae are obligate intracellular pathogens that must coordinate the acquisition of host cell-derived biosynthetic constituents essential for bacterial survival.
D Kesley Robertson +3 more
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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease [PDF]
Nature Communications, 2020 Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Judith Lang +30 more
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Endothelial cells release microvesicles that harbour multivesicular bodies and secrete exosomes [PDF]
Journal of Extracellular Biology, 2023 Extracellular vesicles (EVs) released by endothelial cells support vascular homeostasis. To better understand endothelial cell EV biogenesis, we examined cultured human umbilical vein endothelial cells (HUVECs) prepared by rapid freezing, freeze ...
Jennifer D. Petersen +4 more
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Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia [PDF]
Respiratory Research, 2019 Background Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other ...
Ari Jon Arason +16 more
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Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration [PDF]
Autophagy Reports, 2023 Many neurodegenerative diseases, including Huntington’s disease (HD) and Alzheimer’s disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death.
Ron Benyair +16 more
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