Results 141 to 150 of about 37,167 (216)

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

Cells, 2014
Modification by Lys63-linked ubiquitin (UbK63) chains is the second most abundant form of ubiquitylation. In addition to their role in DNA repair or kinase activation, UbK63 chains interfere with multiple steps of intracellular trafficking.
Zoi Erpapazoglou, Olivier Walker, Rosine Haguenauer-Tsapis   +2 more
doaj   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Defender or accomplice? Dual roles of plant vesicle trafficking in restricting and enabling geminiviral systemic infection

New Phytologist, EarlyView.
Summary The vesicle trafficking system enables multidirectional cargo fluxes between endomembrane compartments. However, vesicle trafficking plays dual roles during pathogen infections. In plants, it mediates autophagic immune responses but can also be hijacked by pathogens to facilitate successful infections.
Pepe Cana‐Quijada, Pablo Morales‐Martínez, Tábata Rosas‐Díaz, Jessica Pérez‐Sancho, Tamara Jiménez‐Góngora, José Antonio Navarro, Rosa Lozano‐Durán, Araceli G. Castillo, Vicente Pallás, Eduardo R. Bejarano   +9 more
wiley   +1 more source

MIRNAS in Astrocyte-Derived Exosomes as Possible Mediators of Neuronal Plasticity

Journal of Experimental Neuroscience, 2016
Astrocytes use gliotransmitters to modulate neuronal function and plasticity. However, the role of small extracellular vesicles, called exosomes, in astrocyte-to-neuron signaling is mostly unknown.
Carlos Lafourcade, Juan Pablo Ramírez, Alejandro Luarte, Anilely Fernández, Ursula Wyneken   +4 more
doaj   +1 more source

From recognition to response: integrated signaling pathways determining pollen acceptance and rejection in Brassicaceae

New Phytologist, EarlyView.
Summary Generation of competent offspring is vital for the prosperity of flowering plants. The pistil not only functions as a conduit for pollen tubes to grow to the ovary but also provides a selective venue for facilitating the growth of compatible pollen tubes and discouraging invaders and incompatible pollen.
Tong Zhang, Shuyan Li, Shengwei Dou, Qiaohong Duan   +3 more
wiley   +1 more source

Identification of the SNARE complex that mediates the fusion of multivesicular bodies with the plasma membrane in exosome secretion. [PDF]

J Extracell Vesicles, 2023
Liu C, Liu D, Wang S, Gan L, Yang X, Ma C.   +5 more
europepmc   +1 more source

Heat Shock Transcription Factor OsHsfc1a Enhances Rice Seedling Thermotolerance by Regulating OsMFT1 and Preserving Chloroplast Structure Under Heat Stress

Plant Biotechnology Journal, EarlyView.
ABSTRACT High‐temperature stress severely threatens rice (Oryza sativa L.) growth and productivity, particularly during the seedling stage, making heat tolerance an essential breeding target. In this study, we identified the heat shock transcription factor OsHsfc1a as a positive regulator of thermotolerance in rice seedlings.
Jingqin Lu, Junyu Chen, Hong Chen, Ziqiang Fan, Lin Lin, Chuanhe Liu, Xiaoxian Wu, Jilei Huang, Zhenlan Liu, Jing Li, Chuxiong Zhuang, Shaoyan Zheng   +11 more
wiley   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases. [PDF]

Genes Dis, 2023
Xu M, Ji J, Jin D, Wu Y, Wu T, Lin R, Zhu S, Jiang F, Ji Y, Bao B, Li M, Xu W, Xiao M.   +12 more
europepmc   +1 more source