Results 161 to 170 of about 37,167 (216)

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling

open access: yesJournal of Extracellular Biology, Volume 5, Issue 2, February 2026.
Human mesenchymal stem cells conditionally secrete sonic hedgehog (SHH)‐containing extra‐large extracellular vesicles (XLEVs) upon PI3K activation, which enriches the GDP‐bound form of Rab18. Rab18‐GDP drives perinuclear maturation and polarized vertical release of SHH‐XLEVs via Hsp90α‐ and nSMase2‐dependent mechanisms.
Shuo Wang   +3 more
wiley   +1 more source

Ultrastructure of the reproductive system of the black swamp snake (\u3ci\u3eSeminatrix pygaea\u3c/i\u3e). Part III. The sexual segment of the male kidney. [PDF]

open access: yes, 2002
In mature male snakes and lizards, a distal portion of the nephron is hypertrophied in relation to its appearance in females and immature males. This sexual segment of the male kidney apparently provides seminal fluid that is mixed with sperm and ...
Sever, David M.
core   +1 more source

Separation Methods Affect Glycan Patterns in Extracellular Vesicle Preparations From Canine Osteoblasts and Osteosarcoma Cells

open access: yesJournal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) are nanosized, membrane‐enclosed particles released by cells, facilitating intercellular communication via the transfer of bioactive molecules from producing to recipient cells. EVs are involved in several physiological and pathological processes, including cancer progression.
Daniela Cortes Galvez   +3 more
wiley   +1 more source

Potential clinical utility of small extracellular vesicles derived from head and neck tumours

open access: yesVIEW, Volume 7, Issue 1, February 2026.
Small extracellular vesicles (EVs) carry selective protein cargoes that reflect tumour cell status, making them valuable for biomarker discovery. This study compared EV proteomes from head and neck cancer (HNC) tumour tissue, saliva and plasma. Over 60% of proteins were shared across all sources, with enrichment in cancer‐related pathways such as ...
Abolfazl Jangholi   +6 more
wiley   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

open access: yesInternational Journal of Dermatology, Volume 65, Issue 2, Page 257-272, February 2026.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari   +2 more
wiley   +1 more source

Multivesicular bodies mimicking SARS-CoV-2 in patients without COVID-19. [PDF]

open access: yesKidney Int, 2020
Calomeni E   +5 more
europepmc   +1 more source

Effects of Periodontal‐Specific Exosomes and rhBMP2 on Osteogenic Behaviour and Differentiation of BMSCs

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Growth factors, including recombinant human bone morphogenetic protein‐2 (rhBMP2), have been clinically utilised for large bone augmentation with good outcomes. Nevertheless, long‐term healing, swelling, safety concerns, and high cost limit their use.
Paras Ahmad   +6 more
wiley   +1 more source

Exosomes in Hypertrophic Scars and Keloids: Mechanisms and Therapeutic Potentials—A Narrative Review

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Hypertrophic scars and keloids, types of pathological scars, arise from dysregulated wound healing, marked by abnormal fibroblast activation and excessive extracellular matrix (ECM) deposition. Current treatments have high recurrence rates and side effects, necessitating targeted therapies. Exosomes, extracellular vesicles mediating
Mengke Wu   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy