Dynamic reorganization of multivesicular bodies and exosome production impacted by sonoporation [PDF]
Scientific ReportsNaturally occurring cell-derived extracellular vesicles (EVs) have emerged as attractive nanocarriers for drug delivery. However, production of large quantities of EVs for clinical applications in a scalable manner remains a significant challenge.
Weiping Li +6 more
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TMEM88 Inhibits Wnt Signaling by Promoting Wnt Signalosome Localization to Multivesicular Bodies [PDF]
iScience, 2019 Summary: Wnt/β-catenin signaling is regulated in a bimodal fashion during cardiogenesis. Signaling is initially required to promote generation of precardiac mesoderm, but subsequently must be repressed for cardiac progenitor specification.
Heejin Lee, Todd Evans
doaj +2 more sources
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies. [PDF]
PLoS ONE, 2012 BACKGROUND: In addition to lowering cholesterol, statins are thought to beneficially modulate inflammation. Several chemokines including CXCL1/growth-related oncogene (GRO)-α, CXCL8/interleukin (IL)-8 and CCL2/monocyte chemoattractant protein (MCP)-1 are
Johanna Hol +10 more
doaj +2 more sources
IKKγ/NEMO Localization into Multivesicular Bodies. [PDF]
Int J Mol Sci, 2022 The NF-κB pathway is central pathway for inflammatory and immune responses, and IKKγ/NEMO is essential for NF-κB activation. In a previous report, we identified the role of glycogen synthase kinase-3β (GSK-3β) in NF-κB activation by regulating IKKγ/NEMO.
Wackernagel LM +7 more
europepmc +4 more sources
Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization [PDF]
Nature CommunicationsMitochondria are maternally inherited, but the mechanisms underlying paternal mitochondrial elimination after fertilization are far less clear. Using Drosophila, we show that special egg-derived multivesicular body vesicles promote paternal mitochondrial
Sharon Ben-Hur +14 more
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Identification of atypical peri-nuclear multivesicular bodies in oxidative and glycolytic skeletal muscle of aged and Pompe’s Disease mouse models [PDF]
Frontiers in Physiology, 2015 Muscle wasting that occurs during aging or from disease pathology presents with an accumulation of lipid species termed ceroid or lipofuscin. This unique species of lipid has been characterized in various cell types but its properties and organization ...
Brian eNeel +3 more
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CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies. [PDF]
Mol Biol Cell, 2012 Ubiquitination of the epidermal growth factor receptor (EGFR) by cbl and its cognate adaptor cbl-interacting protein of 85 kDa (CIN85) is known to play an essential role in directing this receptor to the lysosome for degradation.
Schroeder B +4 more
europepmc +3 more sources
Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies [PDF]
Biology OpenKasumi Suzuki +4 more
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The diagnostic and therapeutic potential of exosomal proteins in breast cancer
Успехи молекулярной онкологии, 2023 Exosomes are membrane vesicles 30–150 nm in size released by cells upon fusion of multivesicular bodies with the plasma membrane. A distinctive feature of these vesicles is the presence of the surface tetraspanins CD9, CD63, and CD81.
A. A. Shefer +2 more
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Structural Insights into AQP2 Targeting to Multivesicular Bodies. [PDF]
Int J Mol Sci, 2019 Vasopressin-dependent trafficking of AQP2 in the renal collecting duct is crucial for the regulation of water homeostasis. This process involves the targeting of AQP2 to the apical membrane during dehydration as well as its removal when hydration levels have been restored. The latter involves AQP2 endocytosis and sorting into multivesicular bodies (MVB)
Roche JV +4 more
europepmc +5 more sources