Results 201 to 210 of about 37,167 (216)
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Receptor downregulation and multivesicular-body sorting
Nature Reviews Molecular Cell Biology, 2002The sorting of proteins into the inner vesicles of multivesicular bodies is required for many key cellular processes, which range from the downregulation of activated signalling receptors to the proper stimulation of the immune response. Recent advances in our understanding of the multivesicular-body sorting pathway have resulted from the ...
David J, Katzmann +2 more
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Nuclear multivesicular bodies in cultured hamster cells
Experientia, 1973Mit elektronenmikroskopischer Untersuchung von BHK 21 cl 13 Zellen wurden multivesikulare Korperchen im Karyoplasma festgestellt, Strukturen, die direkt der inneren Kernmembran entstammen. Die multivesikularen Korperchen wie auch die internen vesikularen Elemente (ϕ 90 nm) waren von einer einzigen Membran umgeben.
C J, Conti, A J, Klein-Szanto
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Multivesicular Bodies and Multivesicular Endosomes: The "Ins and Outs" of Endosomal Traffic
Science's STKE, 2002Multivesicular endosomes (MVEs) are complex intracellular organelles that function in endocytosis. A major function of the endocytic pathway is to sort internalized macromolecules and membrane proteins. Appropriately sorted proteins, such as epidermal growth factor (EGF) receptor (EGFR), are incorporated into MVEs before transport to the lysosomal ...
Philip D, Stahl, M Alejandro, Barbieri
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The Secret Ballet Inside Multivesicular Bodies
ACS NanoLipid bilayers possess the capacity for self-assembly due to the amphipathic nature of lipid molecules, which have both hydrophobic and hydrophilic regions. When confined, lipid bilayers exhibit astonishing versatility in their forms, adopting diverse shapes that are challenging to observe through experimental means. Exploiting this adaptability, lipid
Luis S. Mayorga, Diego Masone
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On the presence of multivesicular bodies inLeishmania donovani
Experientia, 1969Nel presente lavoro gli autori hanno riferito la presenza di corpi multivescicolari inLeishmania donovani. Le vescicole di questi corpi si formano nei vacuoli dell'apparato di Golgi. Le immagini al microscopio elettronico mostrano chiaramente i segni dell'attivita litica dei corpi multivescicolari.
W, Djaczenko, F, Filadoro, R, Pezzi
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Cytochemical studies of the multivesicular bodies
Proceedings, annual meeting, Electron Microscopy Society of America, 1990Multivesicular bodies were observed frequently in electron microscope photographs of Leydig cells from normal adult rat testes. Their formation, evolution and fate were analyzed morphologically in preparations treated to show cytidine monophosphatase ( CMPase ) activity and in animals sacrificed at various time intervals ranging from 5 minutes to 2 ...
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Viral entry: a detour through multivesicular bodies
Nature Cell Biology, 2005Many viruses and toxins enter the cytoplasm of cells by crossing endosomal membranes. New evidence now suggests that if entry occurs through multivesicular bodies, then they are first delivered into intraluminal vesicles before their final transfer into the cytoplasm via the 'back-fusion' of these vesicles.
Pradeep Uchil, Walther Mothes
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Reconstituting Multivesicular Body Biogenesis with Purified Components
2012Activated cell surface receptors are rapidly removed from the plasma membrane through clathrin mediated endocytosis and transported to the endosome where they are either recycled or sorted to the lysosomal pathway to be degraded. Receptors, destined for degradation in the lysosome, are packaged into intraluminal vesicles (ILVs) of endosomes by a ...
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Lennert's Lymphoma with Giant Multivesicular Lysosomal Bodies Optically Visible
Ultrastructural Pathology, 1992A case of a 43-year-old male patient with lymphoepithelioid lymphoma is discussed. During the 10-year follow-up of this patient, different biopsy specimens were obtained. Immunohistochemical studies with a complete paraffin panel determined a T-cell nature of the specimens.
H, Oliva +7 more
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Megakaryocyte dense granule components are sorted in multivesicular bodies
Blood, 2000Recent studies suggest that multivesicular bodies are an intermediate stage in the formation of -granules. In contrast, the kinetics and mode of appearance of dense granules during megakaryocytic maturation has remained poorly understood. Immunoelectron microscopy was used to monitor the appearance of dense granular markers (granulophysin and ...
T, Youssefian, E M, Cramer
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