Results 21 to 30 of about 37,167 (216)

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS) [PDF]

, 2010
Background: Amyotrophic lateral sclerosis (ALS), a common late-onset neurodegenerative disease, is associated with fronto-temporal dementia (FTD) in 3-10% of patients.
Adrian Higginbottom, Alice Brockington, Andrew J. Grierson, Christine E. Burness, Emily F. Goodall, Hannah C. Hollinger, Heather Mortiboys, Janine Kirby, Judith A. Hartley, Karen E. Morrison, Laura E. Cox, Laura Ferraiuolo, Mark R. Cookson, Pamela J. Shaw, Paul G. Ince, Paul R. Heath, Stephen B. Wharton   +16 more
core   +12 more sources

The identification of high-performing antibodies for Charged multivesicular body protein 2b for use in Western Blot, immunoprecipitation and immunofluorescence [version 1; peer review: 2 approved]

F1000Research, 2023
Charged multivesicular body protein 2B is a subunit of the endosomal sorting complex required for transport III (ESRCT-III), a complex implicated in the lysosomal degradation pathway and formation of multivesicular bodies.
Peter S. McPherson, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Walaa Alshafie, Maryam Fotouhi, Irina Shlaifer   +6 more
doaj   +1 more source

Pre-implantation mouse embryos cultured In vitro under different oxygen concentrations show altered ultrastructures [PDF]

, 2020
Assisted Reproductive Technologies routinely utilize different culture media and oxygen (O2) concentrations to culture human embryos. Overall, embryos cultured under physiological O2 tension (5%) have improved development compared to embryos cultured ...
Antonouli, S, Belli, M, Macchiarelli, G, Nottola, Sa, Palmerini, Mg, Rinaudo, P, Ruggeri, E   +6 more
core   +1 more source

Biogenesis and Function of Multivesicular Bodies [PDF]

Annual Review of Cell and Developmental Biology, 2007
The two major cellular sites for membrane protein degradation are the proteasome and the lysosome. Ubiquitin attachment is a sorting signal for both degradation routes. For lysosomal degradation, ubiquitination triggers the sorting of cargo proteins into the lumen of late endosomal multivesicular bodies (MVBs)/endosomes.
Robert C, Piper, David J, Katzmann
openaire   +2 more sources

Coxsackievirus A9 infects cells via nonacidic multivesicular bodies. [PDF]

J Virol, 2014
ABSTRACT Coxsackievirus A9 (CVA9) is a member of the human enterovirus B species in the Enterovirus genus of the family Picornaviridae . According to earlier studies, CVA9 binds to αVβ3 and αVβ6 integrins on the cell surface and utilizes β2-microglobulin, dynamin, and ...
Huttunen M, Waris M, Kajander R, Hyypiä T, Marjomäki V.   +4 more
europepmc   +6 more sources

Biogenesis of Plant Prevacuolar Multivesicular Bodies [PDF]

Molecular Plant, 2016
Plant prevacuolar compartments (PVCs), or multivesicular bodies (MVBs), are single membrane-bound organelles that play important roles in mediating protein trafficking to vacuoles in the secretory pathway. PVC/MVB also serves as a late endosome in the endocytic pathway in plants.
Yong, Cui, Jinbo, Shen, Caiji, Gao, Xiaohong, Zhuang, Junqi, Wang, Liwen, Jiang   +5 more
openaire   +2 more sources

Cargo sorting into multivesicular bodies in vitro [PDF]

Proceedings of the National Academy of Sciences, 2009
Genetic studies have identified a number of proteins required for the internalization of biosynthetic and endocytic cargo proteins transported to the multivesicular body (MVB). We have developed a cell-free reaction that recapitulates the internalization of a yeast biosynthetic membrane cargo protein, carboxypeptidase S (CPS), into
John H, Tran, Ching-Jen, Chen, Scott, Emr, Randy, Schekman   +3 more
openaire   +2 more sources

Endosome transcriptomics reveal trafficking of Cajal bodies into multivesicular bodies. [PDF]

Proc Natl Acad Sci U S A
All eukaryotic cells secrete exosomes, a type of extracellular vesicles derived from the endocytic compartments known as multivesicular bodies (MVBs), or late endosomes (LEs). Exosomes contain a diverse range of cargo such as nucleic acids, proteins, lipids, and small molecules but whether these contents have a biological function remains an area of ...
Singh J, Williams JK, Elliott Q, Jhawar R, Ferguson L, Collins K, Schekman R.   +6 more
europepmc   +2 more sources

Multivesicular Bodies and Autophagy in Erythrocyte Maturation [PDF]

Autophagy, 2005
During reticulocyte maturation, hematopoietic progenitors undergo numerous changes to reach the final functional stage which concludes with the release of reticulocytes and erythrocytes into circulation. During this process some proteins, which are not required in the mature stage, are sequestered in the internal vesicles present in multivesicular ...
Claudio M, Fader, María I, Colombo
openaire   +2 more sources

Wnt Signaling: Multivesicular Bodies Hold GSK3 Captive [PDF]

Cell, 2010
Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt ...
Niehrs, Christof, Acebron, Sergio P.
openaire   +2 more sources