Results 61 to 70 of about 37,167 (216)
A functional study of AUXILIN-LIKE1 and 2, two putative clathrin uncoating factors in Arabidopsis [PDF]
, 2018 Clathrin-mediated endocytosis (CME) is a cellular trafficking process in which cargoes and lipids are internalized from the plasma membrane into vesicles coated with clathrin and adaptor proteins. CME is essential for many developmental and physiological
Adamowski, Maciek +5 more
core +2 more sources
Multivesicular bodies: co-ordinated progression to maturity
Current Opinion in Cell Biology, 2008 Multivesicular endosomes/bodies (MVBs) sort endocytosed proteins to different destinations. Many lysosomally directed membrane proteins are sorted onto intralumenal vesicles, whilst recycling proteins remain on the perimeter membrane from where they are removed via tubular extensions.
Woodman, Philip G., Futter, Clare E.
openaire +2 more sources
Molecular mechanism of multivesicular body biogenesis by ESCRT complexes [PDF]
Nature, 2010 When internalized receptors and other cargo are destined for lysosomal degradation, they are ubiquitinated and sorted by the endosomal sorting complex required for transport (ESCRT) complexes 0, I, II and III into multivesicular bodies. Multivesicular bodies are formed when cargo-rich patches of the limiting membrane of endosomes bud inwards by an ...
Wollert, Thomas, Hurley, James
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Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes
eLife, 2019 Extracellular vesicles (EVs) encompass a variety of vesicles secreted into the extracellular space. EVs have been implicated in promoting tumor metastasis, but the molecular composition of tumor-derived EV sub-types and the mechanisms by which molecules ...
Morayma M Temoche-Diaz +6 more
doaj +1 more source
The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation
Nature Communications, 2018 Cell surface receptors are thought to be internalized via the multivesicular bodies (MVBs) in an ESCRT-dependent pathway. Here, the authors report that in yeast, a hexose transporter is internalized via an ESCRT-independent pathway into intralumenal ...
Erin Kate McNally +1 more
doaj +1 more source
The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions. [PDF]
, 2015 Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport.
Capmany, Anahi +7 more
core +1 more source
Do Plant Cells Secrete Exosomes Derived from Multivesicular Bodies? [PDF]
Plant Signaling & Behavior, 2007 Multivesicular bodies (MVBs) are spherical endosomal organelles containing small vesicles formed by inward budding of the limiting membrane into the endosomal lumen. In mammalian red cells and cells of immune system, MVBs fuse with the plasma membrane in an exocytic manner, leading to release their contents including internal vesicles into the ...
Qianli, An +2 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
Nature Communications, 2019 Exosomes are intercellular signaling vesicles created by fusion of multivesicular bodies (MVBs) and the plasma membrane (PM), but secretory regulation is ill-defined. Song et al.
Lin Song +10 more
doaj +1 more source
ESCRT complexes and the biogenesis of multivesicular bodies [PDF]
Current Opinion in Cell Biology, 2008 Multivesicular bodies (MVBs) are crucial intermediates in the trafficking of ubiquitinated receptors and other cargo destined for lysosomes. The formation of MVBs by invagination of the endosomal limiting membrane is catalyzed by the endosomal sorting complex required for transport (ESCRT) complexes, a process that has recently been visualized in three-
openaire +2 more sources