Results 91 to 100 of about 430 (266)

Município e democratização: a fórmula do Leopardo

Cadernos de Estudos Sociais, 2011
Perante insustentabilidade do modelo de desenvolvimento aplicado ao Nordeste e urgente a reformulação de idéias, conceitos e metodologias, procurando construir um novo paradigma. Para mudar esta realidade insustentável, todos os aspectos da vida política
Carlos Julio Jara
doaj  

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Sistemas de informação em saúde no nível local

Cadernos de Saúde Pública
A importância que a informação vem assumindo na sociedade moderna transformou-a em recurso estatégico de poder em todas as áreas. É fundamental, portanto, que o processo de descentralização no setor saúde não se restrinja a ações em serviços, mas ...
Maria Alice Fernandes Branco
doaj  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

The Funds Policy and the Federative Responsibilities for the Offer of Basic Education

Fineduca, 2020
Since 1997, Brazil has counted on accounting funds to finance basic education, the Fund for the Maintenance and Development of Elementary Education and the Valorization of Teaching (Fundef, from 1997 to 2006) and the Fund for Maintenance and Development ...
Nalú Farenzena
doaj  

L’apolitisme municipal [PDF]

Bulletin d'histoire politique, 2012
Bherer, Laurence, Breux, Sandra
openaire   +4 more sources

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

O Fundef e a Educação Básica em São Paulo: análise de quatro municípios

Educação: Teoria e Prática, 2007
This paper presents a comparison of the performances adopted by municipalities in the State of São Paulo: Leme, Pirassununga, Rio Claro and Limeira, during the period between 1996 - 2000, executing the constitutional obligations regarding the supply of ...
Theresa Maria de Freitas Adrião, Adriana A. Dragone Silveira   +1 more
doaj  

Double Democratization and the Politics of Property in Municipalist Barcelona

Journal of Political Sociology
This contribution proposes a conceptual lens on analyzing the political engagements with property by the new municipalist government of Barcelona (2015-2023) as a two-pronged approach to democratization: On the one side, the municipalists intended to ...
Markus Kip, Silke van Dyk
doaj   +1 more source

Health reform and Indigenous health policy in Brazil: contexts, actors and discourses. [PDF]

Health Policy Plan, 2020
de M Pontes AL, Santos RV.
europepmc   +1 more source