Results 111 to 120 of about 430 (266)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Lessons learnt from international environmental agreements for the Stockholm + 50 Conference: celebrating 20 Years of INEA. [PDF]

Int Environ Agreem, 2022
Gupta J, Vegelin C, Pouw N.
europepmc   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Adoção de “Sistema Privado de Ensino”: análise de dois municípios paulistas

Educação: Teoria e Prática, 2013
This article aims to analyze the process of adopting the "private system of education" in two counties, with a view to teaching autonomy against the curriculum standards.
Rosilene Rodrigues da Silva Souza, Frederico Rodrigues Póvoa Leal   +1 more
doaj  

Provincial dances theatre: From a local project to a flagship of contemporary choreography in 35 years

Управление культурой
The article is devoted to the consideration of the phenomenon of the domestic dance theater, which appeared in Russia in the early 1990s, and one of the iconic representatives of which is the Yekaterinburg troupe "Provincial Dances".
Natalia V. Kuryumova
doaj   +1 more source

The 10-year treatment outcome of open dialogue-based psychiatric services for adolescents: A nationwide longitudinal register-based study. [PDF]

Early Interv Psychiatry, 2022
Bergström T, Seikkula J, Alakare B, Kurtti M, Köngäs-Saviaro P, Löhönen E, Miettunen J, Mäkiollitervo H, Taskila JJ, Virta K, Valtanen K.   +10 more
europepmc   +1 more source

Physics‐Embedded Neural Network: A Novel Approach to Design Polymeric Materials

Advanced Science, EarlyView.
Traditional black‐box models for polymer mechanics rely solely on data and lack physical interpretability. This work presents a physics‐embedded neural network (PENN) that integrates constitutive equations into machine learning. The approach ensures reliable stress predictions, provides interpretable parameters, and enables performance‐driven, inverse ...
Siqi Zhan, Hengheng Zhao, Haotian Wang, Zhanjie Liu, Qian Li, Weifeng Zhang, Qingsong Zhao, Liqun Zhang, Jun Liu   +8 more
wiley   +1 more source

Adoption of a Photocopied Course Packet Teaching System in Ipeuna, Sao Paulo, Brazil

Educação: Teoria e Prática, 2011
This work investigated and analyzed the adoption the consequences of the publicprivate partnership the town of Ipeuna, in the state of Sao Paulo, with regard to the adoption of a photocopied course packet teaching system.
Alessandra Aparecida Cain
doaj  

Does public ownership of utilities matter for local government water policies? [PDF]

Util Policy, 2020
Homsy GC, Warner ME.
europepmc   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source