Results 111 to 120 of about 3,415 (314)
Advanced Science, EarlyView.Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai +15 more
wiley +1 more source
Municipalization and decentralization of the national state : empty autonomy or strengthening of operational capacity? [PDF]
, 2003 Los cambios operados en la Argentina de la última década van desde la Reforma del Estado a una desocupación que supera los índices históricos. La llamada Municipalización del Estado, como uno de los cambios relevantes, será nuestro objeto de estudio.
Fernández Hasan , Valeria
core
IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury
Advanced Science, EarlyView.IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang +18 more
wiley +1 more source
Health reform and Indigenous health policy in Brazil: contexts, actors and discourses. [PDF]
Health Policy Plan, 2020 de M Pontes AL, Santos RV.
europepmc +1 more source
Recent Research on Municipal Sludge as Soil Fertilizer in China: a Review. [PDF]
Water Air Soil Pollut, 2023 Zhang B, Zhou X, Ren X, Hu X, Ji B.
europepmc +1 more source
ELABELA Targets Mitochondria to Modulate Heart Development
Advanced Science, EarlyView.The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang +22 more
wiley +1 more source
Sistemas de informação em saúde no nível local
Cadernos de Saúde PúblicaA importância que a informação vem assumindo na sociedade moderna transformou-a em recurso estatégico de poder em todas as áreas. É fundamental, portanto, que o processo de descentralização no setor saúde não se restrinja a ações em serviços, mas ...
Maria Alice Fernandes Branco
doaj
Spatial analysis of the epidemiological risk of leprosy in the municipalities of Minas Gerais. [PDF]
PLoS Negl Trop Dis, 2023 Bueno IC, Lages DDS, Lana FCF.
europepmc +1 more source
Advanced Science, EarlyView.In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu +16 more
wiley +1 more source
O Fundef e a Educação Básica em São Paulo: análise de quatro municípios
Educação: Teoria e Prática, 2007 This paper presents a comparison of the performances adopted by municipalities in the State of São Paulo: Leme, Pirassununga, Rio Claro and Limeira, during the period between 1996 - 2000, executing the constitutional obligations regarding the supply of ...
Theresa Maria de Freitas Adrião +1 more
doaj