Results 241 to 250 of about 10,374 (334)

Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell of Streptococcus pneumoniae. [PDF]

open access: yesProc Natl Acad Sci U S A
Perez AJ   +7 more
europepmc   +1 more source

Hemocytes: Central drivers of antimicrobial peptide expression and immune proteins in both cellular and humoral responses of Galleria mellonella

open access: yesEntomologia Experimentalis et Applicata, EarlyView.
We assessed gallerimycin, galiomycin, and hemolin gene expression in Galleria mellonella whole larvae, hemocytes, and fat body at 4 and 24 h post‐injection of Candida albicans and silica beads. Higher gallerimycin and galiomycin expression in hemocytes signified their role in antimicrobial peptide synthesis.
Serhat Kaya   +2 more
wiley   +1 more source

Considerations and challenges of septic arthritis and osteomyelitis

open access: yesEquine Veterinary Education, EarlyView.
Summary Septic arthritis remains a common orthopaedic condition in both human and veterinary medicine which can cause serious morbidity and pose considerable challenges for clinical management. The majority of the published clinical research in humans and veterinary species has been focused on the diagnosis, treatment, prevention and outcome of this ...
J. B. Engiles, H. L. Stewart
wiley   +1 more source

Molecular mechanisms of hotspot variants in cytoskeletal β‐actin associated with Baraitser–Winter syndrome

open access: yesThe FEBS Journal, EarlyView.
Variants at position R196 in cytoskeletal β‐actin are the most common variants associated with Baraitser–Winter cerebrofrontofacial syndrome and result in craniofacial anomalies and neurodevelopmental disorders, most likely due to neuronal migration defects. This study explores the molecular mechanisms of p.R196 variants using purified proteins.
Johannes N. Greve, Dietmar J. Manstein
wiley   +1 more source

First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus

open access: yesThe FEBS Journal, EarlyView.
The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi   +15 more
wiley   +1 more source

Genomic context analysis enables the discovery of an unusual NAD‐dependent racemase in phosphonate catabolism

open access: yesThe FEBS Journal, EarlyView.
The authors identify PbfF (previously annotated as a NAD‐dependent dehydrogenase) as a hitherto unknown enzyme in phosphonate catabolism. Guided by genome context analysis, they show that PbfF is actually a racemase, serving to degrade the natural compound (S)‐2‐amino‐1‐hydroxyethylphosphonate (S‐HAEP).
Francesca Ruffolo   +8 more
wiley   +1 more source

In situ imaging and microbiome analysis of calculus‐like deposits at the root apex: A case report of refractory apical periodontitis

open access: yesInternational Endodontic Journal, EarlyView.
Abstract Aim This case report explored the application of next‐generation sequencing (NGS) and fluorescence in situ hybridization (FISH) to visualize and characterize microbial populations in a refractory endodontic infection with apical calculus‐like deposits, a rarely reported phenomenon.
Fernando J. Mota de Almeida   +4 more
wiley   +1 more source

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