Results 21 to 30 of about 123,116 (255)

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response.

open access: yesPLoS ONE, 2020
Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expression of the nuclear and mitochondrial genomes. This represents a unique challenge that highlights the importance of nuclear-
M Isabel G Lopez Sanchez   +8 more
doaj   +1 more source

PENGARUH PEMBERIAN TUAK TERHADAP GAMBARAN HISTOPATOLOGI HATI MENCIT (Mus musculus) ICR JANTAN

open access: yesJurnal Pendidikan Matematika dan IPA, 2020
Liver damage or liver disease is caused by many factors, one of which is by consuming drinks that contain alcohol. Tuak is one of the drinks that contain alcohol.
St Aisyah Sijid   +3 more
doaj   +1 more source

Pengaruh Konsumsi Minuman Instan dengan Frekuensi Berbeda Terhadap Kadar Ureum Darah Mencit (Mus musculus)

open access: yesBioeksperimen: Jurnal Penelitian Biologi, 2015
Minuman instan yang dikemas dalam kantong plastik dapat dijual dan ditemukan pada toko-toko, warung kecil, dan pedagang kaki lima dengan bebas. Masyarakat tidak menyadari bahwa mengkonsumsi minuman instan berlebihan dapat mengganggu kesehatan, karena ...
Agung Mulyatmo, Hariyatmi Hariyatmi
doaj   +1 more source

HISTOLOGICAL STUDY OF THE EFFECT OF THE PARASITE Trichomonas vaginalis ON SOME ORGANS OF THE WHITE SWISS MICE STRAIN BALB/C [PDF]

open access: yesمجلة جامعة الانبار للعلوم الصرفة, 2013
The study showed that the effect of experimental Trichomonasis caused histological change to some of organs under investigation (prostate and testes and penis) in albino rats .In our study, albino rats were divided into three groups [Group I (Single ...
AYSIR S. MOHAMMAD   +2 more
doaj   +1 more source

Schallsignale Der Hausmaus (Mus Musculus) [PDF]

open access: yesBehaviour, 1974
a) Es wurden 8 verschiedene Laute der weisen Labormaus (Mus musculus, Stamm NMRI) nach Struktur und Auslosbarkeit untersucht und ihre mogliche Bedeutung fur die innerartliche Verstandigung diskutiert. b) Mit Hilfe von Sonagrammen, Spektrogrammen und Linienspektren konnen die Laute folgendermasen charakterisiert werden: 1. Schmerzlaut erwachsener Mause :
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Transcriptomic study of anastasis for reversal of ethanol-induced apoptosis in mouse primary liver cells

open access: yesScientific Data, 2022
Measurement(s) Microarray Analysis Technology Type(s) Microarray Analysis Sample Characteristic - Organism Mus ...
Ho Man Tang   +3 more
doaj   +1 more source

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