Results 151 to 160 of about 4,861 (176)

Musashi 2 in hematopoiesis

Current Opinion in Hematology, 2012
Recent work has shown that the Musashi 2 (Msi2) gene plays important roles in normal and malignant hematopoiesis. Here, we give an overview on the role of Msi2 in the regulation and function of primitive hematopoietic cells as well as in leukaemic progression.
Luisa, de Andrés-Aguayo, Florencio, Varas, Thomas, Graf   +2 more
openaire   +2 more sources

Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation [PDF]

Journal of Biological Chemistry, 2019
The Musashi family of mRNA translational regulators control both physiological and pathological stem cell self-renewal primarily by repressing target mRNAs that promote differentiation.
Melanie C Macnicol, Nicola K Gray, Gwen V Childs   +2 more
exaly   +4 more sources

Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue

Andrologia, 2021
MUSASHI (MSI) family plays the main role in the spermatogenesis process. The purpose of this study was the assessment of sperm MSI1 and MSI2, and sperm functional tests in infertile men (n = 30) with varicocele and fertile men (n = 30). Furthermore, MSI1 and MSI2 proteins were assessed in testicular tissue of azoospermic men (n = 9) as well as ...
Zohreh Talebi‐Yazdabadi, Neda Jahanbakhsh, Kianoush Dormiani, Mahboobeh Forouzanfar, Liana Lachinani, Dina Zohrabi, Marziyeh Tavalaee, Mohammad Hossein Nasr‐Esfahani   +7 more
openaire   +2 more sources

PLAG1 and USF2 Regulate Primitive Hematopoietic Expression of Musashi-2

Blood, 2015
Abstract The Musashi-2 (MSI2) RNA binding protein is now recognized as a key regulator of hematopoietic stem cells (HSCs). Its expression is most elevated in the primitive HSC compartment and progressively decreases with differentiation.
Muluken S Belew, Stefan Rentas, Laura de Rooij, Kristin J Hope   +3 more
openaire   +1 more source

The Musashi 2 mRNA Expression in the Course of CML.

Blood, 2012
Abstract Abstract 2552 The Musashi (MSI) gene family members, MSI1 and MSI2, represent an evolutionarily conserved family of RNA-binding proteins that regulate mRNA translation through binding in their N-termini. High levels of MSI2 protein are associated with increased cell proliferation, decreased cell maturation, more ...
Sylvie Nadvornikova, Marketa Zackova, Tereza Lopotova, Hana Klamova, Jana Moravcova   +4 more
openaire   +1 more source

Small molecule inhibition of multiple RNA binding proteins underlies Musashi-2 independent phenotypes

2022
ABSTRACTRNA binding proteins (RBPs) are key regulators of gene expression. Small molecules targeting these RBP-RNA interactions are a rapidly emerging class of therapeutics for treating a variety of diseases. Ro-08-2750 (Ro) is a small molecule inhibitor identified as a competitive inhibitor of Musashi(MSI)-RNA interactions.
Kathryn Walters, Marcin Piotr Sajek, Aaron Issaian, Amber Baldwin, Evan Harrison, Elisabeth Murphy, Miles Daniels, Julie Haines, Kirk Hansen, Angelo D’Alessandro, Neelanjan Mukherjee   +10 more
openaire   +1 more source

High expression of Musashi-2 indicates poor prognosis in adult B-cell acute lymphoblastic leukemia

Leukemia Research, 2013
Musashi-2 (MSI2) expression of 116 adult B-cells acute lymphoblastic leukemia (B-ALL) patients was measured by real-time PCR. Kaplan-Meier analysis showed that patients with high MSI2 expression had inferior overall survival (OS) (P=0.004), event free survival (EFS) (P=0.001) and relapse free survival (RFS) (P=0.018) in BCR-ABL-negative B-ALL ...
Qitian, Mu, Yungui, Wang, Bing, Chen, Wenbin, Qian, Haitao, Meng, Hongyan, Tong, Feifei, Chen, Qiuling, Ma, Wanmao, Ni, Saijuan, Chen, Jie, Jin   +10 more
openaire   +2 more sources

Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation

Cancer Letters, 2017
Accumulating evidence suggests that cancer stem cells (CSCs), a small subset of cancer cells, are responsible for tumor initiation, progression, relapse and metastasis. Musashi 2 (MSI2), a RNA-binding protein, was proposed to be a potent oncogene playing key roles in myeloid leukemia and gastrointestinal malignancies.
Tian, Fang, Hongwei, Lv, Fuquan, Wu, Changzheng, Wang, Ting, Li, Guishuai, Lv, Liang, Tang, Linna, Guo, Shanhua, Tang, Dan, Cao, Mengchao, Wu, Wen, Yang, Hongyang, Wang   +12 more
openaire   +2 more sources

Blood cancer driver Musashi-2 as therapeutic target in chronic lymphocytic leukemia

Leukemia, 2021
Lukas Kazianka, Philipp B. Staber
openaire   +2 more sources

CHARACTERIZATION OF MUSASHI-2 IN HEMATOPOIETIC STEM CELLS

2016
The life-long production of blood cells is enabled by hematopoietic stem and progenitor cells (HSPC) residing in the bone marrow. An understanding of the genes that control how HSPCs work to sustain the continued production of blood cells will enable new therapies to expand them for life-saving transplantation therapies.
openaire   +1 more source