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Musashi1: an RBP with versatile functions in normal and cancer stem cells
Frontiers in Bioscience - Landmark, 2012 Musashi1 (Msi1) is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability to regulate sensory organ development and asymmetric cell division. Studies in mammalian cells reveal multiple functions for Musashi1 in normal and abnormal processes by mediating different post-transcriptional processes.
Luiz O F Penalva, Robert I Glazer
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Expression of the neural RNA‐binding protein Musashi1 in human gliomas
Glia, 2001AbstractTumor cells arising from a particular tissue may exhibit the same gene expression patterns as their precursor cells. To test this proposition, we have analyzed the expression of a neural RNA‐binding protein, Musashi1, in primary human central nervous system (CNS) tumors.
Yutaka Kawakami +2 more
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The oncogenic RNA-binding protein Musashi1 is regulated by tumor suppressor miRNAs [PDF]
RNA Biology, 2011 Musashi1 (Msi1) is an evolutionarily conserved RNA-binding protein that has been implicated in processes like stem cell fate, nervous system development, and tumorigenesis via its activities as a specific regulator of translation. While Msi1 is barely detected in normal adult tissue, it has been observed to be highly expressed in numerous tumor types ...
Andrew D Smith, Luiz O Penalva
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Visual Activity Regulates Neural Progenitor Cells in Developing Xenopus CNS through Musashi1 [PDF]
Neuron, 2010 Regulation of progenitor cell fate determines the numbers of neurons in the developing brain. While proliferation of neural progenitors predominates during early central nervous system (CNS) development, progenitor cell fate shifts toward differentiation as CNS circuits develop, suggesting that signals from developing circuits may regulate ...
Hollis T Cline
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Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells [PDF]
RNA Biology, 2018 RNA binding proteins have emerged as critical oncogenic factors and potential targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy to treat glioblastoma (GBM); the most aggressive brain tumor type. Msi1 expression levels are often high in GBMs and other tumor types and correlate with poor clinical outcome ...
Zhonghua Wang +2 more
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Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1 [PDF]
RNA Biology, 2014 Musashi1 is an RNA binding protein that controls the neural cell fate, being involved in maintaining neural progenitors in their proliferative state. In particular, its downregulation is needed for triggering early neural differentiation programs.
Ubaldo Gioia +2 more
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Spatiotemporal patterns of Musashi1 expression during inner ear development
NeuroReport, 2004Musashi1 (Msi 1) is an RNA binding protein associated with asymmetric cell divisions in neural progenitor cells. To investigate the involvement of Msi1 in the inner ear development, we studied the expression of Msi1 in mouse inner ears with RT-PCR and immunohistochemistry.
Hirofumi, Sakaguchi +5 more
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Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP [PDF]
Journal of Cell Biology, 2008 Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural stem cells. We previously reported that Msi1 contributes to the maintenance of the immature state and self-renewal activity of neural stem cells through translational repression of m-Numb. However, its translation repression mechanism has remained unclear.
Ken Matsumoto, Hideyuki Okano
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Expression of the RNA‐binding protein Musashi1 in adult liver stem‐like cells
Hepatology Research, 2010Aim: Musashi1 is an RNA‐binding protein that regulates the Notch signaling pathway in stem cells. Our previous study revealed that Musashi1 is expressed in early hepatocytes during liver development in the mouse. However, whether this unique protein is expressed with Notch signaling markers in adult liver stem‐like cells remains unknown.Methods ...
Etsuko, Hattori +10 more
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Expression of the Neural RNA-Binding Protein Musashi1 in Pediatric Brain Tumors
Pediatric Neurosurgery, 2007Musashi1 (MSI1) is an evolutionarily conserved RNA-binding protein, selectively expressed in neural stem cells (NSCs) and considered a versatile marker for normal NSCs and tumor cell diagnosis. Here, we examined MSI1 expression in primary pediatric brain tumors, medulloblastomas and ependymomas, by double immunostaining with lineage phenotypic markers (
Aya, Nakano +9 more
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