Results 11 to 20 of about 57,597 (217)

Beyond dopamine blockade: mechanistic humility and the rise of muscarinic, TAAR1, and glutamatergic pathways in schizophrenia [PDF]

Frontiers in Psychiatry
The approval of the first non–dopamine-blocking therapy for schizophrenia marks a defining moment in psychiatry. Muscarinic M1/M4 modulation, alongside emerging TAAR1 and glutamatergic pathways, signals a shift beyond dopamine dominance toward circuit ...
Fawad Taj, Fawad Taj
doaj   +2 more sources

Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model [PDF]

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
A new galvanic skin response‐based approach offers a simple method for measuring sweating in the paws of mice. This method is used to demonstrate that cannabinoid CB1 receptors reduce baseline sweating in mice, likely via inhibition of sympathetic acetylcholine release via axonal CB1 receptors.
Natalia Murataeva, Joseph Youkilis, Yogith Rao, Alex Straiker   +3 more
wiley   +2 more sources

Presencia de anticuerpos contra neurorreceptores cardiacos de acetilcolina muscarínicos tipo II en pacientes con enfermedad de Chagas e implantación de marcapasos

Biomédica: revista del Instituto Nacional de Salud, 2009
Introducción. En diferentes tipos de afecciones cardiacas, incluida la enfermedad de Chagas, se ha descrito la presencia de anticuerpos que reconocen neurorreceptores cardiacos.
María Clara Echeverry, Nubia Catalina Tovar, Guillermo Mora   +2 more
doaj   +1 more source

Cholinergic Signaling, Neural Excitability, and Epilepsy

Molecules, 2021
Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with neuronal hyperexcitability. Apart from the classical imbalance between excitatory glutamatergic transmission and inhibitory γ-aminobutyric acidergic transmission ...
Yu Wang, Bei Tan, Yi Wang, Zhong Chen
doaj   +1 more source

Cholinergic control of visual categorisation in macaques

Frontiers in Behavioral Neuroscience, 2011
Acetylcholine (ACh) is a neurotransmitter acting via muscarinic and nicotinic receptors that is implicated in several cognitive functions and impairments, such as Alzheimer’s disease. It is believed to especially affect the acquisition of new information,
Nikolaos C. Aggelopoulos, Stefanie eLiebe, Stefanie eLiebe, Nikos K Logothetis, Gregor eRainer, Gregor eRainer   +5 more
doaj   +1 more source

Contribution of Postjunctional M2 Muscarinic Receptors to Cholinergic Nerve-Mediated Contractions of Murine Airway Smooth Muscle

Function, 2022
Postjunctional M2Rs on airway smooth muscle (ASM) outnumber M3Rs by a ratio of 4:1 in most species, however, it is the M3Rs that are thought to mediate the bronchoconstrictor effects of acetylcholine.
Tuleen Alkawadri, Lorcan P McGarvey, N D Mullins, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant   +5 more
doaj   +1 more source

Alkoxytrimethylammonium salts and muscarine [PDF]

Experientia, 1953
Es wird die azetylcholinahnliche Wirkung der Alkoxytrimethylammoniumsalze aufgezeigt und im Vergleich zur Struktur der naturlichen Muskarine diskutiert.
E F, RIGERS, D, BOVET, V G, LONGO, G B, MARINI-BETTOLO   +3 more
openaire   +2 more sources

Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine

Frontiers in Physiology, 2015
Both beta adrenergic and muscarinic receptor stimulation independently potentiate arrhythmogenesis. However, the effect of simultaneous stimulation on arrhythmogenesis is not well known.
Amara eGreer-Short, Steven ePoelzing
doaj   +1 more source

Antihypertensive effect and the underlying mechanisms of action of phytolaccagenin in rat models

Clinical and Experimental Hypertension, 2022
Background Phytolaccagenin, a natural triterpenoid, is reported for various biological activities that indicate its potential role in the management of hypertension.
Imran Ul Haq, Taseer Ahmad, Taous Khan, Abdul Jabbar Shah   +3 more
doaj   +1 more source

Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning

Frontiers in Behavioral Neuroscience, 2019
The olfactory bulb (OB) receives significant cholinergic innervation and widely expresses cholinergic receptors. While acetylcholine (ACh) is essential for olfactory learning, the exact mechanisms by which ACh modulates olfactory learning and whether it ...
Jordan M. Ross, Mounir Bendahmane, Max L. Fletcher   +2 more
doaj   +1 more source