Results 21 to 30 of about 57,597 (217)
Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor
Journal of Chemical Theory and Computation, 2023 Patient symptom relief is often heavily influenced by the residence time of the inhibitor-target complex. For the human muscarinic receptor 3 (hMR3), tiotropium is a long-acting bronchodilator used in conditions such as asthma or chronic obstructive pulmonary disease (COPD). The mechanistic insights into this inhibitor remain unclear; specifically, the
Buigues, Pedro J. +7 more
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A Computational Model of the Cholinergic Modulation of CA1 Pyramidal Cell Activity
Frontiers in Computational Neuroscience, 2020 Dysfunction in cholinergic modulation has been linked to a variety of cognitive disorders including Alzheimer's disease. The important role of this neurotransmitter has been explored in a variety of experiments, yet many questions remain unanswered about
Adam Mergenthal +3 more
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Muscarinic Action of Acetylcholine [PDF]
Nature, 1971 THE muscarinic excitatory action of acetylcholine on central and peripheral neurones has been suggested to involve a reduction in membrane conductance for potassium ions1,2. This proposal was supported by observations that 2,4-dinitrophenol (DNP) could specifically suppress the excitation by acetylcholine of cerebral cortical neurones in the cat ...
C R, Curtis, D, Felix
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Frontiers in Behavioral Neuroscience, 2015 The medial prefrontal cortex (mPFC) is a key brain region for the control of consummatory behavior. Neuronal activity in this area is modulated when rats initiate consummatory licking and reversible inactivations eliminate reward contrast effects and ...
Marc Alexander Parent +4 more
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Frontiers in Neural Circuits, 2021 Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan +2 more
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Muscarinic receptor oligomerization [PDF]
Neuropharmacology, 2018 G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins. However, in recent years, a growing number of studies has supported the hypothesis that these receptors can interact to form dimers and higher order oligomers
Marsango, Sara +3 more
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Pharmaceuticals, 2020 Muscarinic acetylcholine receptors (mAChRs) are a pivotal constituent of the central and peripheral nervous system. Yet, therapeutic and diagnostic applications thereof are hampered by the lack of subtype selective ligands.
Marius Ozenil +8 more
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Journal of FungiThe global trend of increasing mushroom consumption, combined with traditional practices in Romania and other Eastern European countries of collecting and consuming “wild mushrooms”, may contribute to the rising incidence of emergency presentations due ...
Bogdan Oprita +4 more
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Paying attention to smell: Cholinergic signaling in the olfactory bulb.
Frontiers in Synaptic Neuroscience, 2014 The tractable, layered architecture of the olfactory bulb (OB), and its function as a relay between odor input and higher cortical processing, makes it an attractive model to study how sensory information is processed at a synaptic and circuit level. The
Rinaldo David D'Souza +1 more
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Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of Drug-Receptor Binding [PDF]
International Neurourology Journal, 2012 The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed.
Shizuo Yamada +3 more
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