Results 121 to 130 of about 29,139 (279)

Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease. [PDF]

Neuronal Signal, 2022
Dwomoh L, Tejeda GS, Tobin AB.
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review

British Journal of Pharmacology, Volume 182, Issue 7, Page 1416-1445, April 2025.
Abstract In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new chemical entities were approved, the number of ‘orphan’ drug authorisations in 2024 (21) is ...
Stavros Topouzis, Andreas Papapetropoulos, Steve P. H. Alexander, Miriam Cortese‐Krott, Dave A. Kendall, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Mauro M. Teixeira, Nathalie Vergnolle, Xin Wang, Péter Ferdinandy   +16 more
wiley   +1 more source

Pharmacological Profiling of a Brugia malayi Muscarinic Acetylcholine Receptor as a Putative Antiparasitic Target. [PDF]

Antimicrob Agents Chemother, 2023
Gallo KJ, Wheeler NJ, Elmi AM, Airs PM, Zamanian M.   +4 more
europepmc   +1 more source

Predicting novel pharmacological activities of compounds using PubChem IDs and machine learning (CID-SID ML model) [PDF]

arXiv
Significance and Object: The proposed methodology aims to provide time- and cost-effective approach for the early stage in drug discovery. The machine learning models developed in this study used only the identification numbers provided by PubChem.
arxiv  

The binding of pirenzepine to digitonin‐solubilized muscarinic acetylcholine receptors from the rat myocardium [PDF]

, 1986
N.J.M. Birdsall, Edward C. Hulme, Mary Keen   +2 more
openalex   +1 more source

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

A Rab10-ACAP1-Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling. [PDF]

Cell Mol Life Sci, 2023
Xu R, Wan M, Shi X, Ma S, Zhang L, Yi P, Zhang R.   +6 more
europepmc   +1 more source

Mechanism of acetylcholine release: possible involvement of presynaptic muscarinic receptors in regulation of acetylcholine release and protein phosphorylation.

, 1979
D. M. Michaelson, Sofia Avissar, Yoel Kloog, Mordechai Sokolovsky   +3 more
openalex   +1 more source

Immunologic mimicry by a monoclonal antibody of the tricyclic anti-depressants' binding site on muscarinic acetylcholine receptors. [PDF]

, 1987
Stéfano Marullo, Johan Hoebeke, J G Guillet, Carl André, A. Donny Strosberg   +4 more
openalex   +1 more source

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

The FEBS Journal, Volume 292, Issue 8, Page 2017-2050, April 2025.
SUCNR1, activated by succinate, is a Gi‐ and Gq‐coupled receptor present at the plasma membrane and in endosomes. There are conflicting reports about the pro‐/anti‐inflammatory effects of the succinate‐SUCNR1 signaling axis, and these are likely due to localization‐dependent signaling.
Aenne‐Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia‐Marcos, Robert Kraft, Claudia Stäubert   +11 more
wiley   +1 more source