Results 121 to 130 of about 52,106 (303)
FEBS Open Bio, Volume 15, Issue 7, Page 1041-1053, July 2025.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
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Medication Causes and Treatment of Delirium in Patients With and Without Dementia
Brain and Behavior, Volume 15, Issue 7, July 2025.Medication associated risk related to cause and treatment of delirium ABSTRACT Introduction Medication associated with delirium in adult patients is poorly understood and considered both a predisposing and precipitating factor. Prescribing advice is lacking. This systematic review aims to collate evidence on medication risks in delirium associated with
Anita Elaine Weidmann +5 more
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Journal of Pharmacological Sciences, 2008 Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-to-cell signaling in almost all life-forms on earth. Cholinergic components, including ACh, choline acetyltransferase, acetylcholinesterase, and muscarinic and nicotinic ACh ...
Significance Koichiro Kawashima +1 more
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Piperine Enhances Mitochondrial Biogenesis to Mitigate Stress in SH‐SY5Y Neuroblastoma Cells
Food Science &Nutrition, Volume 13, Issue 7, July 2025.Piperine increases the expression of mitochondrial biogenesis, leading to increased mitochondrial mass, enhanced Ca2+ influx, and upregulation of mitochondrial metabolic enzymes. These effects help mitigate mitochondrial injury‐induced neuronal death caused by 6‐OHDA.
Nongluk Saikachain +9 more
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Hippocampus, Volume 35, Issue 4, July 2025.ABSTRACT Obstructive sleep apnea (OSA), characterized by repetitive upper airway obstruction, leads to chronic intermittent hypoxia (cIH) and induces cognitive and neuronal network disruptions similar to those observed in Alzheimer's disease (AD). These pathologies are often presented together in the elderly and share some pathophysiological mechanisms.
Laura Pinedo‐Vargas +4 more
wiley +1 more source
Allosteric interactions at the M3 muscarinic acetylcholine receptor
, 2023 The extracellular loops of muscarinic acetylcholine receptors are predicted to play a role in the binding and regulation of allosteric modulators. Furthermore, the sequence of the five subtypes of muscarinic receptors shows a large degree of diversity in this region.
openaire +4 more sources
Digital Chinese Medicine, 2018 : Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by ...
Wei-Jie Qiang +11 more
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PRESYNAPTIC MUSCARINIC RECEPTORS INHIBITING ACTIVE ACETYLCHOLINE RELEASE IN THE BULLFROG SYMPATHETIC GANGLION [PDF]
, 1982 K. Koketsu, Masanobu Yamada
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Hailey‐Hailey Disease: An Updated Review With a Focus on Therapeutic Mechanisms
Health Science Reports, Volume 8, Issue 7, July 2025.ABSTRACT Background Hailey‐Hailey disease (HHD), or familial benign chronic pemphigus, is a rare autosomal dominant genodermatosis characterized by chronic, painful, erythematous, erosive plaques and fissures at sites of friction such as the neck, axilla, groin, and perineum.
Mahesh Mathur +4 more
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Acetylcholine acts on m2‐muscarinic receptors to excite rat locus coeruleus neurones [PDF]
, 1985 Terrance M. Egan, R. Alan North
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