Results 121 to 130 of about 7,723 (245)

Enhancing Dopamine Accumulation in Secretory Vesicles of PC12 Cells: Mechanisms, Applications and Limitations

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Schematic representation of a large dense‐core vesicle in PC12 cells highlighting its main molecular organization. The diagram illustrates the presence of membrane transporters, proton pumps and intravesicular matrix proteins that establish the electrochemical gradients required for neurotransmitter uptake, vesicle acidification and efficient storage ...
Noemi Socas‐Pérez, Ricado Borges, José David Machado   +2 more
wiley   +1 more source

Cloning, sequence analysis and chromosome localization of a Drosophila muscarinic acetylcholine receptor

, 1989
Two cDNA clones (3.7 kb and 4.8 kb) encoding a Drosophila muscarinic acetylcholine receptor were isolated from a Drosophila head cDNA library and characterized by automated DNA sequence analysis.
Michael G. FitzGerald, Venter, J. C., Linda M. Hall, Gocayne, Jeannine D., Hall, Linda M., Fraser, C. M., Claire M. Fraser, W.Richard McCombie, Deborah A. Urquhart, FitzGerald, Michael G., Jeannine D. Gocayne, Takeshi Onai, Urquhart, Deborah A., Gocayne, J. D., Arakawa, Shoji, Fraser, Claire M., Onai, Takeshi, Urquhart, D. A., Arakawa, S., McCombie, W.Richard, J.Craig Venter, McCombie, W. R., FitzGerald, M. G., Onai, T., Venter, J.Craig, Hall, L. M., Shoji Arakawa   +26 more
core   +1 more source

The regulation of M₁ muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons¹ [PDF]

, 2007
Jonathon M. Willets, Carl P. Nelson, Stefan R. Nahorski, R. A. John Challiss   +3 more
openalex   +1 more source

Quantification and reliability of [11C]VC - 002 binding to muscarinic acetylcholine receptors in the human lung — a test-retest PET study in control subjects [PDF]

, 2020
Zsolt Cselényi, Aurelija Jučaitė, Cecilia Kristensson, Per Stenkrona, Pär Ewing, Andrea Varrone, Peter Johnström, Magnus Schou, Ana Vázquez‐Romero, Mohammad Mahdi Moein, Martin Bolin, Jonathan Siikanen, Pär Grybäck, Bengt Larsson, Christer Halldin, Ken Grime, Ulf G. Eriksson, Lars Farde   +17 more
openalex   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Computational Quantification of Peristalsis in Preclinical Mouse Models Using Smartphone Videography

Neurogastroenterology &Motility, Volume 38, Issue 6, June 2026.
A new computational method and analytical pipeline for quantifying gut peristalsis in live mouse models that involves taking a video using a smartphone camera and then processing the videographic data using our custom analytical pipeline to quantify gastrointestinal motility.
Joseph C. Schindler, Gargi Vijayan Pillai, Thomas M. Raffay, Satish E. Viswanath, Puneet Seth   +4 more
wiley   +1 more source

Parasympathetic overdrive as a cause of overactive bladder in a high‐fat‐diet‐induced obesity mouse model

The Journal of Physiology, Volume 604, Issue 12, Page 4945-4967, 15 June 2026.
Abstract figure legend Obesity and metabolic syndrome (MetS) are well‐known major risk factors for overactive bladder (OAB). Mechanisms underlying obesity‐/MetS‐associated OAB were explored using a high‐fat‐diet (HFD)‐induced obesity mouse model. HFD‐induced obesity/MetS mice developed an OAB phenotype characterized by enlarged non‐voiding contractions
Ayu Sugiura, Retsu Mitsui, Kyoko Miwa‐Nishimura, Hikaru Hashitani   +3 more
wiley   +1 more source

Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor

The M1 muscarinic acetylcholine receptor (M1R) is highly expressed in the nervous system, and has been studied to discover new therapeutic drugs for a range of neurological and psychiatric disorders.
Amiri, Shayan
core  

ANTIINFLAMMATORY ROLE OF CENTRAL MUSCARINIC ACETYLCHOLINE RECEPTORS. [PDF]

, 2003
Valentin A. Pavlov, Svetlana Ivanova, Mahendar Ochani, Luis Ulloa, Haichao Wang, C. A. Amella, Hong Liao, Jaehee Han, Christopher J. Czura, Kevin J. Tracey   +9 more
openalex   +1 more source

Envolvimento do receptor NMDA de glutamato na ansiedade experimental induzida pela pilocarpina [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.A ansiedade é vista pela ciência moderna como um conjunto de comportamentos, com respostas ...
Oliveira, Alanny Bahia de
core