Results 121 to 130 of about 54,223 (288)
Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy
MedComm, Volume 7, Issue 4, April 2026.In this review, we summarize nerve–cancer interactions and conclude two additional interactions, “perineural invasion” and “neuro‐microbic‐oncology.” Emphasizing the important role of nerves in tumor progression. The nervous system also contributes to the development of cancer comorbidities such as cancer depression and cognitive dysfunction.
Ting Wang +5 more
wiley +1 more source
A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies [PDF]
, 2020 Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the ubiquitous neurotransmitter acetylcholine, based on a bacterial periplasmic binding protein.
Borden, Philip M. +4 more
core
VIEW, Volume 7, Issue 2, April 2026.This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu +7 more
wiley +1 more source
Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]
, 2013 Wymke Ockenga +4 more
openalex +1 more source
Addiction Biology, Volume 31, Issue 4, April 2026.This study examined the effects of donepezil on mesolimbic dopamine signalling and alcohol‐related behaviours in male rats. Donepezil increases nucleus accumbens dopamine via muscarinic mechanisms and prevented further dopamine elevation after alcohol administration. Although it did not reduce regular alcohol intake, it abolished relapse‐like drinking.
Anna Loftén +4 more
wiley +1 more source
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
wiley +1 more source
Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome [PDF]
, 2018 Veronica I. Shubayev +2 more
openalex +1 more source
The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro +4 more
wiley +1 more source
The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons1 [PDF]
, 2007 Jonathon M. Willets +3 more
openalex +1 more source
Physiological Reports, Volume 14, Issue 8, April 2026.In newly diagnosed prostate cancer, non‐Hispanic Black men exhibit greater microvascular impairment than non‐Hipanic White men, which may increase cardiovascular disease risk. Abstract Cardiovascular disease (CVD) is a leading cause of mortality in men with prostate cancer (PC), with non‐Hispanic Black (NHB) men experiencing disproportionately higher ...
Abigayle B. Simon +10 more
wiley +1 more source