Results 151 to 160 of about 124,416 (341)
British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano +6 more
wiley +1 more source
Journal of Pharmacological Sciences, 2008 Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-to-cell signaling in almost all life-forms on earth. Cholinergic components, including ACh, choline acetyltransferase, acetylcholinesterase, and muscarinic and nicotinic ACh ...
Significance Koichiro Kawashima +1 more
doaj
PRESYNAPTIC MUSCARINIC RECEPTORS INHIBITING ACTIVE ACETYLCHOLINE RELEASE IN THE BULLFROG SYMPATHETIC GANGLION [PDF]
, 1982 K. Koketsu, Masanobu Yamada
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European Journal of Neurology, Volume 32, Issue 8, August 2025.We review the non‐motor symptoms of MG and their potential pathogenesis, hoping to contribute to personalized diagnosis and treatment. ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junction (NMJ), driven by T cells, mediated by B cells, and dependent on autoantibodies.
Benqiao Wang +3 more
wiley +1 more source
Efficacy of Botulinum Toxin A for the Management of Melasma: A Split‐Face, Randomized Control Study
Journal of Cosmetic Dermatology, Volume 24, Issue 8, August 2025.ABSTRACT Background Melasma management remains challenging due to its multifactorial nature pathogenesis and recurrent nature. Previous studies showed positive effects of botulinum toxin A (BoNT‐A) for treating and preventing ultraviolet‐induced hyperpigmentation.
Sasipim Chaijaras +6 more
wiley +1 more source
Occurrence of muscarinic acetylcholine receptors in wild type and cholinergic mutants of Caenorhabditis elegans [PDF]
, 1983 JG Culotti, WL Klein
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The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Journal of Pharmacological Sciences, 2011 .: In small cell lung carcinoma (SCLC), acetylcholine (ACh) is synthesized and secreted, and it acts as an autocrine growth factor through activation of its receptors, muscarinic receptor (mAChR) and nicotinic receptor (nAChR). Alteration of tumor growth
Nozomi Ami +5 more
doaj
Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction
Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley +1 more source
The binding of pirenzepine to digitonin‐solubilized muscarinic acetylcholine receptors from the rat myocardium [PDF]
, 1986 N.J.M. Birdsall +2 more
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