Results 151 to 160 of about 125,963 (338)
Toxins, 2011 Muscarinic toxin 7 (MT7) is a mamba venom peptide that binds selectively to the M1 muscarinic acetylcholine receptor. We have previously shown that the second (ECL2) and third (ECL3) extracellular loops of the M1 receptor are critically involved in ...
Katja Näreoja +2 more
doaj +1 more source
Organophosphate Poisoning: Insights From a Case Report of Acute Cholinergic Syndrome
Clinical Case Reports, Volume 13, Issue 10, October 2025.ABSTRACT Organophosphate (OP) pesticides are widely used in agriculture and can cause acute cholinergic toxicity by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine. A 45‐year‐old male plumber was admitted to the emergency department 4 h after ingesting an unknown quantity of a 50% emulsifiable concentration of ...
Gudisa Bereda
wiley +1 more source
THE IRREVERSIBLE BINDING OF ACETYLCHOLINE MUSTARD TO MUSCARINIC RECEPTORS IN INTESTINAL SMOOTH MUSCLE OF THE GUINEA‐PIG [PDF]
, 1975 Doreen Robinson +2 more
openalex +1 more source
British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran +9 more
wiley +1 more source
The binding of pirenzepine to digitonin‐solubilized muscarinic acetylcholine receptors from the rat myocardium [PDF]
, 1986 N.J.M. Birdsall +2 more
openalex +1 more source
British Journal of Pharmacology, Volume 182, Issue 19, Page 4710-4728, October 2025.Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada +2 more
wiley +1 more source
A Dopamine-Acetylcholine Cascade: Simulating Learned and Lesion-Induced Behavior of Striatal Cholinergic Interneurons [PDF]
, 2007 The "teaching signal" that modulates reinforcement learning at cortico-striatal synapses may be a sequence composed of an adaptively scaled DA burst, a brief ACh burst, and a scaled ACh pause.
Bullock, Daniel, Tan, Can Ozan
core +1 more source
Purification of the muscarinic acetylcholine receptor from porcine atria [PDF]
, 1984 openalex +1 more source
Internal Medicine Journal, Volume 55, Issue 10, Page 1626-1631, October 2025.Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley +1 more source
Acetylcholine acts on m2‐muscarinic receptors to excite rat locus coeruleus neurones [PDF]
, 1985 Terrance M. Egan, R. Alan North
openalex +1 more source