Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity [PDF]
Scientific Reports, 2017 Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine.
I-Shan Chen +2 more
doaj +2 more sources
Beneficial effects of anisodamine in shock involved nicotinic anti-inflammatory pathway [PDF]
Frontiers in Pharmacology, 2011 Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965.
Ting eZhao +4 more
doaj +3 more sources
Allosteric Modulation of Muscarinic Acetylcholine Receptors [PDF]
Pharmaceuticals, 2010 An allosteric modulator is a ligand that binds to an allosteric site on the receptor and changes receptor conformation to produce increase (positive cooperativity) or decrease (negative cooperativity) in the binding or action of an orthosteric agonist (e.
Esam E. El-Fakahany, Jan Jakubík
doaj +3 more sources
Retraction: Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling. [PDF]
J Biol ChemHirota K +6 more
europepmc +3 more sources
Anti-M3 Muscarinic Acetylcholine Receptor Autoantibody in the Serum and Saliva of Oral Lichen Planus Patients: A Case-Control Study. [PDF]
Health Sci RepABSTRACT Background and Aims Oral lichen planus OLP) is a chronic, T‐cell–mediated disease frequently accompanied by xerostomia. Prior work suggests reduced salivary M3 muscarinic acetylcholine receptor (M3R) may contribute to hyposalivation. We investigated whether anti‐M3R autoantibodies are elevated in serum and saliva of OLP patients compared with ...
Agha-Hosseini F +4 more
europepmc +2 more sources
The role of muscarinic receptors in the beneficial effects of adenosine against myocardial reperfusion injury in rats. [PDF]
PLoS ONE, 2011 Adenosine, a catabolite of ATP, displays a wide variety of effects in the heart including regulation of cardiac response to myocardial ischemia and reperfusion injury.
Lei Sun +8 more
doaj +1 more source
Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM). [PDF]
ACS Chem NeurosciEngers JL +17 more
europepmc +2 more sources
Sexually dimorphic muscarinic acetylcholine receptor modulation of contextual fear learning in the dentate gyrus. [PDF]
Neurobiol Learn Mem, 2021 Yavas E, Trott JM, Fanselow MS.
europepmc +2 more sources
Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype
Journal of Pharmacological Sciences, 2004 Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi +5 more
doaj +1 more source