Results 231 to 240 of about 54,223 (288)
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Muscarinic Acetylcholine Receptors
2004Muscarinic acetylcholine receptors are members of the G-protein-coupled receptor superfamily. There are five genes encoding the muscarinic receptors, which are expressed to different extents in a variety of tissues, including cardiac and smooth muscle, secretory glands, and neurons and glial cells in the central and peripheral nervous systems ...
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Muscarinic acetylcholine receptors and airway diseases
Pharmacology & Therapeutics, 2003Parasympathetic nerves provide the dominant autonomic innervation of the airways. Release of acetylcholine from parasympathetic nerves activates postjunctional muscarinic receptors present on airway smooth muscle, submucosal glands, and blood vessels to cause bronchoconstriction, mucus secretion, and vasodilatation, respectively.
Coulson, Fiona R., Fryer, Allison D.
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Relationship between muscarinic acetylcholine receptor subtypes
HEREDITAS, 2007Muscarinic acetylcholine receptor belongs to the G-coupled receptor family, the cooperation between its five subtypes is crucially important in maintaining the normal physiological function. At present, many types of biological resources are increasing, which provides unprecedented opportunities to study the relationships between muscarinic ...
Hai-Long, Yu +4 more
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Allosteric modulation of muscarinic acetylcholine receptors
Trends in Pharmacological Sciences, 1995Five subtypes of muscarinic acetylcholine receptors have been identified in mammalian tissues, but the selectivity of ligands that are active at these receptors is low. It is possible, however, that selective compounds may be developed by targeting their allosteric site(s).
S, Tucek, J, Proska
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Muscarinic acetylcholine receptors in cat iris
Biochemical Pharmacology, 1979Abstract The binding of tritium labeled N- methyl -4- piperidylbenzilate ([ 3 H ]-4- NMPB ) to fractions obtained from cat irides was investigated. The binding of this highly potent muscarinic antagonist to the cat iris consisted of two components: (a) high affinity binding sites with low capacity and (b) low affinity binding sites ...
Y, Kloog +4 more
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Antidepressants and the Muscarinic Acetylcholine Receptor
Archives of General Psychiatry, 1977Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones.
S H, Snyder, H I, Yamamura
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Muscarinic acetylcholine receptors of rat lymphocytes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1983The muscarinic acetylcholine receptors on rat lymphocytes were determined by [3H]quinuclidinyl benzilate binding studies. Binding of [3H]quinuclidinyl benzilate is rapid (half saturation occurred within 120 s) and highly specific. Muscarinic receptors reveal high lability. The number of receptors on plasma membrane depends on time of incubation as well
W, Maśliński +3 more
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Regulation of muscarinic acetylcholine receptor signaling
Pharmacology & Therapeutics, 2003Multiple mechanisms regulate the signaling of the five members of the family of the guanine nucleotide binding protein (G protein)-coupled muscarinic acetylcholine (ACh) receptors (mAChRs). Following activation by classical or allosteric agonists, mAChRs can be phosphorylated by a variety of receptor kinases and second messenger-regulated kinases.
Chris J, van Koppen, Björn, Kaiser
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Muscarinic Acetylcholine Receptor Activators
2014Modulation of muscarinic acetylcholine receptors (mAChRs) is one of the most attractive therapeutic strategies for the treatment of schizophrenia. Pilot clinical studies of the M1/M4 mAChR-preferring agonist xanomeline as well as animal studies using M1–M5 mAChR knockout mice suggest that selective activation of M1 and/or M4 mAChRs is a key concept in ...
Takaaki Sumiyoshi, Takeshi Enomoto
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Molecular Biology of Muscarinic Acetylcholine Receptors
Critical Reviews™ in Neurobiology, 1996Following the molecular cloning of five distinct muscarinic acetylcholine receptor (mAChR) genes, the last decade has witnessed an explosion of new knowledge about how mAChRs function at a molecular level. These studies have been greatly facilitated by the molecular characterization of the many components of the signal transduction pathways activated ...
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