Results 311 to 320 of about 124,719 (350)
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Allosteric antagonists of the muscarinic acetylcholine receptor
Biochemical Pharmacology, 1991For the most part, the interaction of these selective antagonists with muscarinic receptors has been interpreted in the context of simple competitive bimolecular reaction which obeys the law of mass action. In fact, the use of selective antagonists as a pharmacological tool to identify receptor types and subtypes is based on this premise.
Esam E. El-Fakahany, Norman H. Lee
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Biochemical Journal, 2013
The literature on GPCR (G-protein-coupled receptor) homo-oligomerization encompasses conflicting views that range from interpretations that GPCRs must be monomeric, through comparatively newer proposals that they exist as dimers or higher-order oligomers,
S. Patowary +6 more
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The literature on GPCR (G-protein-coupled receptor) homo-oligomerization encompasses conflicting views that range from interpretations that GPCRs must be monomeric, through comparatively newer proposals that they exist as dimers or higher-order oligomers,
S. Patowary +6 more
semanticscholar +1 more source
Function of muscarinic and nicotinic acetylcholine receptors
Nature, 1976ACETYLCHOLINE receptors in vertebrates can be classified in two categories—nicotinic and muscarinic—on the basis of differential sensitivity to agonist and antagonist compounds1,2. This pharmacological distinction, although useful both in therapeutics and in experimental physiology, has no known biological significance.
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Muscarinic acetylcholine receptor-interacting proteins (mAChRIPs): targeting the receptorsome.
Current Drug Targets, 2012Muscarinic acetylcholine receptors comprise a large family of G protein-coupled receptors that are involved in the regulation of many important functions of the central and peripheral nervous system. To achieve such a large range of physiological effects,
D. Borroto-Escuela +3 more
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Pharmacological Approaches to Targeting Muscarinic Acetylcholine Receptors
Recent Patents on CNS Drug Discovery, 2014The presence of cholinergic system markers and muscarinic receptor subtypes in several tissues also of nonneuronal type has been largely demonstrated. Acetylcholine, synthesized in the nervous system, can locally contribute to modulate cell proliferation, survival and apoptosis. Considering that the cholinergic system functions are impaired in a number
Claudio Matera, TATA, Ada Maria
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Muscarinic Acetylcholine Receptors in the Urinary Tract
2011Muscarinic receptors comprise five cloned subtypes, encoded by five distinct genes, which correspond to pharmacologically defined receptors (M(1)-M(5)). They belong to the family of G-protein-coupled receptors and couple differentially to the G-proteins.
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Allosteric interactions at muscarinic acetylcholine receptors
2021This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
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Muscarinic acetylcholine receptors in the lung
Biochemical Society Transactions, 1991David C.W. Murray +2 more
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Inhibition by Ketamine of Muscarinic Acetylcholine Receptor Function
Anesthesia & Analgesia, 1995Although ketamine's primary site of action appears to be the phencyclidine receptor on the N-methyl-D-aspartate (NMDA) receptor complex, additional activity on opiate and quisqualate receptors is suggested. Some phencyclidines have been shown to interact with muscarinic receptors, but this has not been determined for ketamine.
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