Results 1 to 10 of about 29,153 (282)

Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling. [PDF]

Asian J Androl, 2018
The autonomic nervous system contributes to prostate cancer proliferation and metastasis. However, the exact molecular mechanism remains unclear. In this study, muscarinic acetylcholine receptor M1 (CHRM1) expression was measured via immunohistochemical ...
Yin QQ, Xu LH, Zhang M, Xu C.
europepmc   +5 more sources

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 2014
Background: Selective and potent positive allosteric modulators (PAMs) of the M1 mAChR have been recently described. Results: Use of structural analogues and mutagenic mapping identified the mechanistic basis for increased PAM activity.
Alaa Abdul‐Ridha, J. Robert Lane, Shailesh N. Mistry, Laura López, Patrick M. Sexton, Peter J. Scammells, Arthur Christopoulos, Meritxell Canals   +7 more
semanticscholar   +12 more sources

Muscarinic acetylcholine receptor M1 mutations causing neurodevelopmental disorder and epilepsy [PDF]

Human Mutation, 2021
De novo rare damaging variants in genes involved in critical developmental pathways, notably regulation of synaptic transmission, have emerged as a frequent cause of neurodevelopmental disorders (NDD).
Anna Marcé‐Grau, Xabier Elorza‐Vidal, Carla Pérez‐Rius, Anna Ruiz, Júlia Sala‐Coromina, Elisabet Gabau, Raúl Estévez, Alfons Macaya   +7 more
semanticscholar   +9 more sources

Flavonoids with M1 Muscarinic Acetylcholine Receptor Binding Activity [PDF]

Molecules, 2014
Muscarinic acetylcholine receptor-active compounds have potential for the treatment of Alzheimer’s disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at ...
Meyyammai Swaminathan, C. Chee, Sek Peng Chin, M. J. Buckle, N. Rahman, S. Doughty, L. Chung   +6 more
semanticscholar   +5 more sources

Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 2014
Background: BQCA is a selective allosteric modulator of the M1 mAChR. Results: Residues that govern BQCA activity were identified using mutagenesis and molecular modeling.
Alaa Abdul‐Ridha, Laura López, Peter Keov, David M. Thal, Shailesh N. Mistry, Patrick M. Sexton, J. Robert Lane, Meritxell Canals, Arthur Christopoulos   +8 more
semanticscholar   +7 more sources

Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 2014
Background: Bitopic ligands bind concomitantly to orthosteric and allosteric receptor sites. Results: Residues affecting binding and biased signaling of the selective agonists TBPB and 77-LH-28-1 were identified at the M1 muscarinic receptor. Conclusion:
Peter Keov, Laura López, Shane M. Devine, Céline Valant, J. Robert Lane, Peter J. Scammells, Patrick M. Sexton, Arthur Christopoulos   +7 more
semanticscholar   +5 more sources

Identification of Antagonistic Action of Pyrrolizidine Alkaloids in Muscarinic Acetylcholine Receptor M1 by Computational Target Prediction Analysis. [PDF]

Pharmaceuticals (Basel)
Pyrrolizidine alkaloids (PAs) are one of the largest distributed classes of toxins in nature. They have a wide range of toxicity, such as hepatotoxicity, pulmonary toxicity, neuronal toxicity, and carcinogenesis.
Abdalfattah S, Knorz C, Ayoobi A, Omer EA, Rosellini M, Riedl M, Meesters C, Efferth T.   +7 more
europepmc   +5 more sources

Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor. [PDF]

Mol Pharmacol
Multiple sclerosis (MS) is growing in prevalence; yet, treatments that can reverse the progression of the disease are still needed. One strategy that has shown promise for reversing MS is remyelination by inhibiting the M1 receptor, a member of the muscarinic acetylcholine receptor (mAChR) family.
Chen K, Park E, Abd-Elrahman KS.
europepmc   +4 more sources

The novel orthosteric agonist M1 muscarinic acetylcholine receptor reveals anti-Alzheimer's disease activity. [PDF]

Sci Rep
Cholinergic treatments with an emphasis on M1 muscarinic acetylcholine receptor (mAChR) agonists as potential modulating agents are a new approach in Alzheimer’s disease (AD) therapy. In previous research, we designed and characterized novel thiazolidine-
Taheri M, Afzali Mehr M, Ghafouri H.
europepmc   +3 more sources

Targeting the M1 muscarinic acetylcholine receptor in Alzheimer’s disease [PDF]

Neuronal Signaling, 2022
Alzheimer’s disease (AD) remains a major cause of morbidity and mortality worldwide, and despite extensive research, only a few drugs are available for management of the disease.
L. Dwomoh, G. Tejeda, A. Tobin
semanticscholar   +3 more sources