Results 21 to 30 of about 28,733 (280)

Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in Chronic Tinnitus [PDF]

Frontiers in Neuroscience, 2017
Chronic tinnitus is characterized by neuroplastic changes of the auditory cortex. A promising method for therapy of chronic tinnitus is vagus nerve stimulation (VNS) combined with auditory stimulation.
Tijana Bojić, Vladimir Perović, Milan Senćanski, Sanja Glišić   +3 more
openalex   +2 more sources

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes [PDF]

Science, 2019
Choosing a partner G protein–coupled receptors (GPCRs) bind ligands outside the cell and trigger events inside the cell by selectively binding and activating specific G proteins. The selectivity occurs even among highly related GPCRs.
S. Maeda, Q. Qu, M. J. Robertson, G. Skiniotis, B. Kobilka   +4 more
semanticscholar   +4 more sources

Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice. [PDF]

J Neurochem
In Alzheimer's disease, reduced release of ACh is linked more to Aβ pathology than to age‐related change, highlighting an early sign of disease. ABSTRACT A progressive decline in cognitive function occurs as a result of aging and Alzheimer's disease (AD) and is primarily associated with diminished cholinergic neurotransmission.
Nagai-Arakawa I, Muramatsu I, Uwada J, Tsuda Y, Tokunaga A, Irie A, Maeda H, Madokoro Y, Sato T, Uchida Y, Saito T, Saido TC, Sada K, Masuoka T, Matsukawa N.   +14 more
europepmc   +2 more sources

Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]

Med Res Rev
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Colleoni A, Galli G, Dallanoce C, De Amici M, Gorostiza P, Matera C.   +5 more
europepmc   +2 more sources

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

Frontiers in Pharmacology, 2021
The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia.
Emma T. van der Westhuizen, K. H. Christopher Choy, Celine Valant, Simon McKenzie-Nickson, Sophie J. Bradley, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos   +7 more
doaj   +2 more sources

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus [PDF]

Cerebral Cortex, 2015
Muscarinic M1 acetylcholine receptors (M1Rs) are highly expressed in the hippocampus, and their inhibition or ablation disrupts the encoding of spatial memory.
Broad, Lisa M, Colvin, Ellen M, Dennis, Siobhan, Felder, Christian C, Fitzjohn, Steve, Isaac, John T R, Mellor, Jack, Mogg, Adrian J, Pasqui, Francesca, Sanger, Helen   +9 more
core   +7 more sources

Allosteric Modulation of M1 Muscarinic Acetylcholine Receptor Internalization and Subcellular Trafficking* [PDF]

Journal of Biological Chemistry, 2014
Background: The effects of allosteric modulators on G protein-coupled receptor trafficking are largely unknown. Results: The allosteric ligand BQCA modulates M1 mAChR arrestin recruitment and receptor trafficking.
Holly R. Yeatman, J. R. Lane, K. H. C. Choy, N. Lambert, P. Sexton, A. Christopoulos, Meritxell Canals   +6 more
semanticscholar   +4 more sources

Structure of the m1 Muscarinic Acetylcholine Receptor Gene and Its Promoter [PDF]

Journal of Biological Chemistry, 1997
The m1 receptor is one of five muscarinic receptors that mediate the metabotropic actions of acetylcholine in the nervous system where it is expressed predominantly in the telencephalon and autonomic ganglia. RNase protection, primer extension, and 5'-rapid amplification of cDNA ends analysis of a rat cosmid clone containing the entire m1 gene ...
S. Pepitoni, Noel J. Buckley, Ian Wood
openalex   +5 more sources

Corrigendum: Striatal dopamine D2-muscarinic acetylcholine M1 receptor-receptor interaction in a model of movement disorders [PDF]

Frontiers in Pharmacology, 2022
René A. J. Crans, René A. J. Crans, Elise Wouters, Marta Valle-León, Marta Valle-León, Jaume Taura, Jaume Taura, Caio M. Massari, Caio M. Massari, Víctor Fernández-Dueñas, Víctor Fernández-Dueñas, Christophe P. Stove, Francisco Ciruela, Francisco Ciruela   +13 more
doaj   +2 more sources

Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene [PDF]

AAPS PharmSci, 2001
The gene encoding the human muscarinic receptor, type 1 (CHRM1), was genotyped from 245 samples of the Coriell Collection (Coriell Institute for Medical Research, Camden, NJ). Fifteen single nucleotide polymorphisms (SNPs) were discovered, 9 of which are located in the coding region of the receptor.
Julie L. Lucas, Wolfgang Sadée, Joseph DeYoung   +2 more
openalex   +4 more sources