Results 31 to 40 of about 29,153 (282)

The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia

Frontiers in Psychiatry
Cognitive impairment is a core symptom of schizophrenia and a major determinant of poor long-term functional outcomes. Despite considerable efforts, we do not yet have any approved pharmacological treatments for cognitive impairment associated with ...
Samantha E. Yohn, Phillip D. Harvey, Stephen K Brannan, W. Horan   +3 more
semanticscholar   +3 more sources

Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]

Med Res Rev
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Colleoni A, Galli G, Dallanoce C, De Amici M, Gorostiza P, Matera C.   +5 more
europepmc   +2 more sources

Corrigendum: Striatal dopamine D2-muscarinic acetylcholine M1 receptor-receptor interaction in a model of movement disorders [PDF]

Frontiers in Pharmacology, 2022
René A. J. Crans, Elise Wouters, Marta Valle-León, Jaume Taura, Caio M. Massari, Víctor Fernández‐Dueñas, Christophe P. Stove, Francisco Ciruela   +7 more
openalex   +3 more sources

Muscarinic Acetylcholine Receptor M1 [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Substituted Benzylspiroindolin-2-one Analogues as Positive Allosteric Modulators of the Muscarinic Acetylcholine Receptor M1. [PDF]

ACS Med Chem Lett, 2013
Rotella DP.
europepmc   +2 more sources

Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction

Molecular Brain, 2016
BackgroundThe development of the nervous system involves an initially exuberant production of neurons that make an excessive number of synaptic contacts. The initial overproduction of synapses promotes connectivity. Hebbian competition between axons with
Laura Nadal, Neus García, Erica Hurtado, Anna Simó, Marta Tomás, María A. Lanuza, Manel M. Santafé, Josep Tomàs   +7 more
openalex   +2 more sources

Potentiation of the M1 muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2 mice

Neurobiology of Disease
Rett syndrome (RTT) is a neurodevelopmental disorder that is caused by loss-of-function mutations in the methyl-CpG binding protein 2 (MeCP2) gene. RTT patients experience a myriad of debilitating symptoms, which include respiratory phenotypes that are ...
Mackenzie Smith, Grace E. Dodis, Amanda M. Vanderplow, Sonia Gonzalez, Yewon Rhee, Karie E. Scrogin, Rocco G. Gogliotti   +6 more
openalex   +3 more sources

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors [PDF]

Nature, 2016
Muscarinic M1-M5 acetylcholine receptors are G-protein-coupled receptors that regulate many vital functions of the central and peripheral nervous systems. In particular, the M1 and M4 receptor subtypes have emerged as attractive drug targets for treatments of neurological disorders, such as Alzheimer's disease and schizophrenia, but the high ...
David A. Evans, Bingfa Sun, Mark G. Bures, Arthur Christopoulos, William I. Weis, Vindhya Nawaratne, Brian K. Kobilka, Katie Leach, Dan Feng, Patrick M. Sexton, Christian C. Felder, Tong Sun Kobilka, Priti Bachhawat, David M. Thal   +13 more
openaire   +3 more sources

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors

Frontiers in Neural Circuits, 2021
Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan, Stefan Everling, Stefan Everling   +2 more
doaj   +1 more source

Characterization of the positive and negative inotropic effects of acetylcholine in the human myocardium [PDF]

, 1995
In the human isolated myocardium, acetylcholine (10−9 to 10−3 M) elicited a biphasic inotropic effect (a decrease in the lower and an increase in the higher concentration range) in atrial and a positive inotropic effect in ventricular trabeculae. However,
Bos, E. (Egbert), Du, X.Y. (Xiaoyi), Saxena, P.R. (Pramod Ranjan), Schoemaker, R.G. (Regien)   +3 more
core   +7 more sources