Results 31 to 40 of about 3,324 (136)

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

Frontiers in Pharmacology, 2021
The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia.
Emma T. van der Westhuizen, K. H. Christopher Choy, Celine Valant, Simon McKenzie-Nickson, Sophie J. Bradley, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos   +7 more
doaj   +1 more source

Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]

World Journal of Research and Review (WJRR) ISSN:2455-3956, Volume-4, Issue-5, May 2017 Pages 26-30, 2020
Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv  

Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation

Frontiers in Immunology, 2019
The brain regulates physiological functions integral to survival. However, the insight into brain neuronal regulation of peripheral immune function and the neuromediator systems and pathways involved remains limited. Here, utilizing selective genetic and
Kurt R. Lehner, Harold A. Silverman, Harold A. Silverman, Meghan E. Addorisio, Ashbeel Roy, Ashbeel Roy, Mohammed A. Al-Onaizi, Mohammed A. Al-Onaizi, Yaakov Levine, Peder S. Olofsson, Peder S. Olofsson, Sangeeta S. Chavan, Sangeeta S. Chavan, Robert Gros, Robert Gros, Robert Gros, Neil M. Nathanson, Yousef Al-Abed, Yousef Al-Abed, Christine N. Metz, Christine N. Metz, Vania F. Prado, Vania F. Prado, Vania F. Prado, Vania F. Prado, Marco A. M. Prado, Marco A. M. Prado, Marco A. M. Prado, Marco A. M. Prado, Kevin J. Tracey, Kevin J. Tracey, Valentin A. Pavlov, Valentin A. Pavlov   +32 more
doaj   +1 more source

Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex.

PLoS ONE, 2022
Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex.
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapman   +5 more
doaj   +1 more source

Cell-Type Specific Neuromodulation of Excitatory and Inhibitory Neurons via Muscarinic Acetylcholine Receptors in Layer 4 of Rat Barrel Cortex

Frontiers in Neural Circuits, 2022
The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties ...
Guanxiao Qi, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +3 more
doaj   +1 more source

Synaptic transmission as a cooperative phenomenon in confined systems [PDF]

Condens. Matter Phys., 2017, vol. 20, No. 1, 13804, 2017
In this review paper, the theory of synaptic transmission (ST) was developed and discussed. We used the hypothesis of isomorphism between: (a) the cooperative behavior of mediators --- acetylcholine molecules (ACh) and cholinoreceptors in a synaptic cleft with binding into mediator-receptor (AChR) complexes, (b) the critical phenomena in confined ...
arxiv   +1 more source

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2012
The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors. Within the last decade several reports have been published suggesting that KYNA also blocks nicotinic acetylcholine receptors (nAChRs) containing the \alpha7 subunit (\alpha7*).
arxiv   +1 more source

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj  

Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors. [PDF]

PLoS ONE, 2014
Xanomeline is an agonist endowed with functional preference for M1/M4 muscarinic acetylcholine receptors. It also exhibits both reversible and wash-resistant binding to and activation of these receptors.
Eva Šantrůčková, Vladimír Doležal, Esam E El-Fakahany, Jan Jakubík   +3 more
doaj   +1 more source

Cholinergic switch between two types of slow waves in cerebral cortex [PDF]

Cerebral Cortex 2019, 2018
Sleep slow waves are known to participate in memory consolidation, yet slow waves occurring under anesthesia present no positive effects on memory. Here, we shed light onto this paradox, based on a combination of extracellular recordings in vivo, in vitro, and computational models.
arxiv   +1 more source