Results 31 to 40 of about 28,733 (280)
Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats [PDF]
Scientific Reports, 2017 The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells.
Marzia Soligo +9 more
doaj +3 more sources
Molecular Brain, 2016 BackgroundThe development of the nervous system involves an initially exuberant production of neurons that make an excessive number of synaptic contacts. The initial overproduction of synapses promotes connectivity. Hebbian competition between axons with
Laura Nadal +7 more
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Functional Analysis of Transmembrane Domain 2 of the M1 Muscarinic Acetylcholine Receptor [PDF]
Journal of Biological Chemistry, 2007 Ala substitution scanning mutagenesis has been used to probe the functional role of amino acids in transmembrane (TM) domain 2 of the M1 muscarinic acetylcholine receptor, and of the highly conserved Asn43 in TM1. The mutation of Asn43, Asn61, and Leu64 caused an enhanced ACh affinity phenotype. Interpreted using a rhodopsin-based homology model, these
Mark S. Bee, Edward C. Hulme
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The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia [PDF]
Frontiers in PsychiatryCognitive impairment is a core symptom of schizophrenia and a major determinant of poor long-term functional outcomes. Despite considerable efforts, we do not yet have any approved pharmacological treatments for cognitive impairment associated with ...
Samantha E. Yohn +4 more
doaj +2 more sources
M1 muscarinic acetylcholine receptor in Alzheimer’s disease [PDF]
Neuroscience Bulletin, 2014 The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified.
Shangtong Jiang +6 more
semanticscholar +4 more sources
Journal of Ayurveda, 2023 Introduction: Mandukaparni, being one of the medhya rasayanas, has shown remarkable therapeutic effects in the management of psychological disorders. Network pharmacology is the latest scientific collaboration where new drug actions can be established ...
T Adarsh, Giridhar Vedantam
doaj +1 more source
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors [PDF]
Nature, 2016 Muscarinic M1-M5 acetylcholine receptors are G-protein-coupled receptors that regulate many vital functions of the central and peripheral nervous systems. In particular, the M1 and M4 receptor subtypes have emerged as attractive drug targets for treatments of neurological disorders, such as Alzheimer's disease and schizophrenia, but the high ...
David A. Evans +13 more
openaire +3 more sources
Frontiers in Neural Circuits, 2021 Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan +2 more
doaj +1 more source
Potentiation of the M<sub>1</sub> muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2<sup>+/-</sup> mice. [PDF]
Neurobiol DisSmith M +6 more
europepmc +2 more sources