Results 31 to 40 of about 15,706 (256)

Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice

Cells, 2023
Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng, Jürgen Wess, Christian Alzheimer   +2 more
doaj   +1 more source

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +1 more source

The effects of kindling during pregnancy on long-term potentiation (LTP) induction and M1 muscarinic acetylcholine receptors in male rat offspring

Research in Pharmaceutical Sciences, 2023
Background and purpose: Neonates of pregnant women with epilepsy may compromise normal neurodevelopment and hippocampal morphology. Memory and learning disorders and a decrease in verbal IQ scores are seen in these children later in life. In the previous
Ali Pourmotabbed, Razieh Naghizadeh, Farshad Moradpour, Mozhgan Veisi, Seyed Ershad Nedaei, Fatemeh Zarei, Zahra Salimi   +6 more
doaj   +1 more source

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors [PDF]

Nature, 2016
Muscarinic M1-M5 acetylcholine receptors are G-protein-coupled receptors that regulate many vital functions of the central and peripheral nervous systems. In particular, the M1 and M4 receptor subtypes have emerged as attractive drug targets for treatments of neurological disorders, such as Alzheimer's disease and schizophrenia, but the high ...
David M, Thal, Bingfa, Sun, Dan, Feng, Vindhya, Nawaratne, Katie, Leach, Christian C, Felder, Mark G, Bures, David A, Evans, William I, Weis, Priti, Bachhawat, Tong Sun, Kobilka, Patrick M, Sexton, Brian K, Kobilka, Arthur, Christopoulos   +13 more
openaire   +2 more sources

Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats

Journal of Biomedical Science, 2009
Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine receptor (mAChR) have been implicated in the
Mathew Jobin, Kumar T Peeyush, Gireesh G, Paulose CS   +3 more
doaj   +1 more source

An in vivo biosensor for neurotransmitter release and in situ receptor activity. [PDF]

, 2010
Tools from molecular biology, combined with in vivo optical imaging techniques, provide new mechanisms for noninvasively observing brain processes. Current approaches primarily probe cell-based variables, such as cytosolic calcium or membrane potential ...
Griesbeck, Oliver, Kleinfeld, David, Mank, Marco, Muller, Arnaud, Nguyen, Quoc-Thang, Schroeder, Lee F, Taylor, Palmer   +6 more
core   +2 more sources

Muscarinic acetylcholine M1 receptor regulates pyroptosis of prostate cancer cells through Caspase-1/GSDMD pathway

Di-san junyi daxue xuebao, 2021
Objective To determine the effect of muscarinic acetylcholine M1 receptor (CHRM1) on pyroptosis of prostate cancer cells and investigate its possible molecular mechanism. Methods Pirenzepine (PIN), a specific CHRM1 antagonist, and bethanechol (BETH), its
CHEN Jinying, ZHANG Mi, ZENG Yan, HUANG Yanping, CHEN Fangfang, WANG Qianhui, XU Chen   +6 more
doaj   +1 more source

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor [PDF]

, 2013
Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus.
Arthur Christopoulos, Aurelio L., Avlani V. A., Barbosa J., Bell R. P., Ben Capuano, Bunce R. A., Canals M., Cao X., Casara P., Celine Valant, Conn P. J., Decker M., Eaton P. E., Gould R. G., Holden M., Koguro K., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Langmead C. J., Lauer W. M., Leach K., Ma L., Maffioli S. I., Meanwell N. A., Medeiros R. R., Patrick M. Sexton, Peter J. Scammells, Podányi B., Reid P. R., Shailesh N. Mistry, Shirey J. K., Wess J., Wise W. M., Yang F. V., Zewge D., Zhang Y., Škugor M. M.   +43 more
core   +2 more sources

Carbachol Induces Ca2+-Dependent Contraction via Muscarinic M2 and M3 Receptors in Rat Intestinal Subepithelial Myofibroblasts

Journal of Pharmacological Sciences, 2009
.: Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine.
Koichi Iwanaga, Takahisa Murata, Muneyoshi Okada, Masatoshi Hori, Hiroshi Ozaki   +4 more
doaj   +1 more source

Neurofunctional reorganization and memory improvements induced by rivastigmine in Alzheimer's disease are mediated by α4β2 nicotinic receptor density [PDF]

Alzheimers Dement
Abstract Background Acetylcholinesterase inhibitors are used to delay cognitive decline due to Alzheimer's disease (AD) by preventing breakdown of acetylcholine. Such treatment appears to be associated with cerebral changes, although the mechanism of action has not been clarified yet.
Manca R, De Marco M, Venneri A.
europepmc   +2 more sources