Results 41 to 50 of about 14,768 (198)

Effect of green flickering light on myopia development and expression of M1 muscarinic acetylcholine receptor in guinea pigs [PDF]

International Journal of Ophthalmology, 2018
AIM: To investigate the effects of green flickering light on refractive development and expression of muscarinic acetylcholine receptor (mAChR) M1 in the eyes of guinea pigs.
Yuan Tao, Xiao-Li Li, Li-Yuan Sun, Yu-Hua Wei, Xiao-Ting Yu, Hong Wang   +5 more
doaj   +1 more source

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

Frontiers in Pharmacology, 2021
The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia.
Emma T. van der Westhuizen, K. H. Christopher Choy, Celine Valant, Simon McKenzie-Nickson, Sophie J. Bradley, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos   +7 more
doaj   +1 more source

Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor. [PDF]

PLoS ONE, 2010
Xanomeline is a unique agonist of muscarinic receptors that possesses functional selectivity at the M(1) and M(4) receptor subtypes. It also exhibits wash-resistant binding to and activation of the receptor.
Marianne K O Grant, Meredith J Noetzel, Kayla C De Lorme, Jan Jakubík, Vladimír Doležal, Esam E El-Fakahany   +5 more
doaj   +1 more source

The actions of Pasteurella multocida toxin on neuronal cells [PDF]

, 2014
Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Duricki, DA, Lax, AJ, Reilly, JM, Robbins, J, Surguy, SM   +4 more
core   +1 more source

Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation

Frontiers in Immunology, 2019
The brain regulates physiological functions integral to survival. However, the insight into brain neuronal regulation of peripheral immune function and the neuromediator systems and pathways involved remains limited. Here, utilizing selective genetic and
Kurt R. Lehner, Harold A. Silverman, Harold A. Silverman, Meghan E. Addorisio, Ashbeel Roy, Ashbeel Roy, Mohammed A. Al-Onaizi, Mohammed A. Al-Onaizi, Yaakov Levine, Peder S. Olofsson, Peder S. Olofsson, Sangeeta S. Chavan, Sangeeta S. Chavan, Robert Gros, Robert Gros, Robert Gros, Neil M. Nathanson, Yousef Al-Abed, Yousef Al-Abed, Christine N. Metz, Christine N. Metz, Vania F. Prado, Vania F. Prado, Vania F. Prado, Vania F. Prado, Marco A. M. Prado, Marco A. M. Prado, Marco A. M. Prado, Marco A. M. Prado, Kevin J. Tracey, Kevin J. Tracey, Valentin A. Pavlov, Valentin A. Pavlov   +32 more
doaj   +1 more source

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]

, 2016
Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark, Han, Xue, Kondabolu, Krishnakanth, Kopell, Nancy, McCarthy, Michelle M., Roberts, Erik A.   +5 more
core   +1 more source

Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex.

PLoS ONE, 2022
Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex.
Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapman   +5 more
doaj   +1 more source

Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]

, 1999
The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC, Brown, DA, Buckley, NJ, Delmas, P, Hadley, JK, London, B, Selyanko, AA, Wood, IC   +7 more
core   +1 more source

FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.

PLoS ONE, 2012
Background and objectiveMuscarinic acetylcholine receptors (mAChRs) are 7-transmembrane, G protein-coupled receptors that regulate a variety of physiological processes and represent potentially important targets for therapeutic intervention.
Danijela Markovic, Jonathan Holdich, Suleiman Al-Sabah, Rajendra Mistry, Cornelius Krasel, Martyn P Mahaut-Smith, R A John Challiss   +6 more
doaj   +1 more source

Cell-Type Specific Neuromodulation of Excitatory and Inhibitory Neurons via Muscarinic Acetylcholine Receptors in Layer 4 of Rat Barrel Cortex

Frontiers in Neural Circuits, 2022
The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties ...
Guanxiao Qi, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +3 more
doaj   +1 more source