Results 61 to 70 of about 28,733 (280)
The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity [PDF]
The EMBO Journal, 1997 Intracellular tyrosine kinases link the G protein-coupled m1 muscarinic acetylcholine receptor (mAChR) to multiple cellular responses. However, the mechanisms by which m1 mAChRs stimulate tyrosine kinase activity and the identity of the kinases within particular signaling pathways remain largely unknown.
Wen‐Tien Tsai
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Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor [PDF]
Proceedings of the National Academy of Sciences, 1998 Several G protein-coupled receptors are known to direct the tyrosine phosphorylation, and in some cases the activation, of diverse tyrosine kinases. Using a stable cell line approach, we characterize the activation of PYK2, a tyrosine kinase structurally related to focal adhesion kinase, by the G protein-coupled m1 muscarinic acetylcholine receptor. We
Teresa G. Cachero +2 more
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Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]
, 2006 In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
58998 +3 more
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Frontiers in Cellular Neuroscience, 2015 Cholinergic inputs into the prefrontal cortex (PFC) are associated with attention and cognition; however there is evidence that acetylcholine also has a role in PFC dependent learning and memory.
Henry Giles Stratten Martin +21 more
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Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization [PDF]
, 2018 Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue.
Marsango, Sara +3 more
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The FASEB Journal, 2018 SUMOylation is a significant post‐translational modification (PTM) by the small ubiquitin‐related modifier (SUMO). Increasing evidence shows SUMOylation regulates GPCR signaling; however, very few GPCRs have been shown to be SUMOylation targets to date ...
Jianrong Xu +10 more
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M1 muscarinic receptor‐mediated facilitation of acetylcholine release in the rat urinary bladder. [PDF]
The Journal of Physiology, 1994 1. Release of [3H]ACh in response to electrical field stimulation (10 Hz) was measured in strips of rat urinary bladder and cardiac atrial tissues previously incubated with [3H]choline. 2. The volley output of [3H]ACh release was positively correlated with frequency of stimulation in the urinary bladder but negatively correlated in the atrium. 3.
George T. Somogyi +2 more
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Effect of green flickering light on myopia development and expression of M1 muscarinic acetylcholine receptor in guinea pigs [PDF]
International Journal of Ophthalmology, 2018 AIM: To investigate the effects of green flickering light on refractive development and expression of muscarinic acetylcholine receptor (mAChR) M1 in the eyes of guinea pigs.
Yuan Tao +5 more
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Identification of multiple allosteric sites on the M1 muscarinic acetylcholine receptor [PDF]
FEBS Letters, 2005 Staurosporine and four staurosporine derivatives were docked on the rhodopsin‐based homology model of the M1 muscarinic acetylcholine receptor in order to localize the possible allosteric sites of this receptor. It was found that there were three major allosteric sites, two of which are located at the extracellular face of the receptor, and one in the ...
José G. Trujillo-Ferrara +1 more
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Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor. [PDF]
PLoS ONE, 2010 Xanomeline is a unique agonist of muscarinic receptors that possesses functional selectivity at the M(1) and M(4) receptor subtypes. It also exhibits wash-resistant binding to and activation of the receptor.
Marianne K O Grant +5 more
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