Revisiting the Endocytosis of the M2 Muscarinic Acetylcholine Receptor [PDF]
Membranes, 2015 The agonist-induced endocytosis of the muscarinic acetylcholine receptor M2 is different from that of the other members of the muscarinic receptor family.
Wymke Ockenga, Ritva Tikkanen
doaj +3 more sources
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes [PDF]
Science, 2019 Choosing a partner G protein–coupled receptors (GPCRs) bind ligands outside the cell and trigger events inside the cell by selectively binding and activating specific G proteins. The selectivity occurs even among highly related GPCRs.
S. Maeda +4 more
semanticscholar +3 more sources
Acetylcholine muscarinic M2 receptor maintains human Schwann-like adipose-derived phenotype in the absence of differentiating medium [PDF]
Cell Death DiscoveryHuman adipose-derived stem cells (ASCs), differentiated in vitro towards Schwann-like phenotype (hdASCs), have been suggested as an alternative source of Schwann cells (SCs).
Roberta Piovesana +3 more
doaj +2 more sources
Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes [PDF]
Journal of Biological Chemistry, 1998 Internalization and down-regulation of human muscarinic acetylcholine m2 receptors (hm2 receptors) and a hm2 receptor mutant lacking a central part of the third intracellular loop (I3-del m2 receptor) were examined in Chinese hamster ovary (CHO-K1) cells
H. Tsuga +5 more
semanticscholar +2 more sources
On homology modeling of the M2 muscarinic acetylcholine receptor subtype [PDF]
Journal of Computer-Aided Molecular Design, 2013 Twelve homology models of the human M2 muscarinic receptor using different sets of templates have been designed using the Prime program or the modeller program and compared to crystallographic structure (PDB:3UON).
J. Jakubík +2 more
semanticscholar +2 more sources
Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor [PDF]
Scientific Reports, 2015 Endocytosis and postendocytic sorting of G-protein-coupled receptors (GPCRs) is important for the regulation of both their cell surface density and signaling profile.
M. Wan +6 more
semanticscholar +3 more sources
Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms * [PDF]
Journal of Biological Chemistry, 1995 The phenomenon of acute desensitization of G-protein-coupled receptors has been associated with several events, including receptor phosphorylation, loss of high affinity agonist binding, receptor:G-protein uncoupling, and receptor internalization ...
R. Pals‐Rylaarsdam +4 more
semanticscholar +3 more sources
Synergistic Regulation of m2 Muscarinic Acetylcholine Receptor Desensitization and Sequestration by G Protein-coupled Receptor Kinase-2 and β-Arrestin-1 [PDF]
Journal of Biological Chemistry, 1997 The m2 muscarinic acetylcholine receptor (m2 mAChR) belongs to the superfamily of G protein-coupled receptors and is regulated by many processes that attenuate signaling following prolonged stimulation by agonist. We used a heterologous expression system
Michael L. Schlador, Neil M. Nathanson
openalex +2 more sources
Modulation of the M2 Muscarinic Acetylcholine Receptor Activity with Monoclonal Anti-M2 Receptor Antibody Fragments [PDF]
Journal of Biological Chemistry, 2004 Antibodies directed against the second extracellular loop of G protein-coupled receptors are known to have functional activities. From a partial agonist monoclonal antibody directed against the M2 muscarinic receptor, we constructed and produced a single chain variable fragment with high affinity for its target epitope.
Jean‐Christophe Peter +6 more
openalex +4 more sources
Muscarinic acetylcholine receptor M2 (CHRM2; HM2) [PDF]
Science-Business eXchange, 2012 Tatsuya Haga, Brian K. Kobilka
openalex +3 more sources