Results 11 to 20 of about 24,506 (124)

Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The orthosteric binding sites of the five muscarinic acetylcholine receptor (mAChR) subtypes are highly conserved, making the development of selective antagonists challenging.
M. Korczynska, M. Clark, C. Valant, Jun Xu, Ee Von Moo, Sabine Albold, Dahlia R. Weiss, Hayarpi Torosyan, Weijiao Huang, A. Kruse, B. Lyda, L. May, Joanne Baltos, P. Sexton, B. Kobilka, A. Christopoulos, B. Shoichet, R. Sunahara   +17 more
semanticscholar   +1 more source

Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients

Cardiology Research and Practice, 2019
Objectives To investigate the association of serum autoantibodies against M2-muscarinic acetylcholine receptor (anti-M2-R) with atrial fibrosis in long-standing persistent atrial fibrillation (AF) patients. Methods Twenty-four long-standing persistent AF
Guiling Ma, Xuejiao Wu, Lijun Zeng, Jiawei Jin, Xingpeng Liu, Jianjun Zhang, Lin Zhang   +6 more
semanticscholar   +1 more source

Resolution of complex fluorescence spectra of lipids and nicotinic acetylcholine receptor by multivariate analysis reveals protein-mediated effects on the receptor's immediate lipid microenvironment [PDF]

PMC Biophysics 2008, 1:6, 2009
Analysis of fluorescent spectra from complex biological systems containing various fluorescent probes with overlapping emission bands is a challenging task. Valuable information can be extracted from the full spectra, however, by using multivariate analysis (MA) of measurements at different wavelengths.
arxiv   +1 more source

Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes

Journal of Biological Chemistry, 1998
Internalization and down-regulation of human muscarinic acetylcholine m2 receptors (hm2 receptors) and a hm2 receptor mutant lacking a central part of the third intracellular loop (I3-del m2 receptor) were examined in Chinese hamster ovary (CHO-K1) cells
H. Tsuga, K. Kameyama, T. Haga, T. Honma, J. Lameh, W. Sadee   +5 more
semanticscholar   +1 more source

Ligand Binding-Induced Structural Changes in the M2 Muscarinic Acetylcholine Receptor Revealed by Vibrational Spectroscopy.

Journal of Physical Chemistry Letters, 2019
M2 muscarinic acetylcholine receptor (M2R) is a prototypical G protein-coupled receptor (GPCR) that responds to acetylcholine and mediates various cellular responses in the nervous system.
K. Katayama, Kohei Suzuki, Ryoji Suno, Hirokazu Tsujimoto, S. Iwata, Takuya Kobayashi, H. Kandori   +6 more
semanticscholar   +1 more source

Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.

Human Molecular Genetics, 2009
It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic ...
S. Cohen-Woods, D. Gaysina, N. Craddock, A. Farmer, J. Gray, C. Gunasinghe, F. Hoda, L. Jones, J. Knight, A. Korszun, M. Owen, A. Sterne, I. Craig, P. McGuffin   +13 more
semanticscholar   +1 more source

A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor [PDF]

Physical Biology, 3(2):147-159, 2006, 2005
The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin.
arxiv   +1 more source

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Nature, 2011
The parasympathetic branch of the autonomic nervous system regulates the activity of multiple organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the response to acetylcholine released from parasympathetic nerves.
K. Haga, A. Kruse, H. Asada, Takami Yurugi-Kobayashi, M. Shiroishi, Cheng Zhang, W. Weis, T. Okada, B. Kobilka, T. Haga, Takuya Kobayashi   +10 more
semanticscholar   +1 more source

Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin [PDF]

Front. Immunol. 2019, 2018
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes
arxiv   +1 more source

Effects of toluene exposure on signal transduction: toluene reduced the signaling via stimulation of human muscarinic acetylcholine receptor m2 subtypes in CHO cells.

Japanese Journal of Pharmacology, 2002
The organic solvent toluene is used widely in industry and is toxic to the central nervous system (CNS). To clarify the mechanisms of CNS toxicity following toluene exposure, especially with respect to the G protein-coupling of receptors, we determined ...
H. Tsuga, T. Haga, T. Honma
semanticscholar   +1 more source