Results 31 to 40 of about 8,829 (221)

Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity

Scientific Reports, 2017
Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine.
I-Shan Chen, Kazuharu Furutani, Yoshihisa Kurachi   +2 more
doaj   +1 more source

M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation

World Allergy Organization Journal, 2013
Airways chronic inflammatory conditions in asthma and COPD are characterized by tissue remodeling, being smooth muscle hyperplasia, the most important feature.
Fabiola A. Placeres-Uray, Christopher A. Febres-Aldana, Ruth Fernandez-Ruiz, Ramona Gonzalez de Alfonzo, Itala A. Lippo de Becemberg, Marcelo J. Alfonzo   +5 more
doaj   +1 more source

Effects mediated by the α7 nicotinic acetylcholine receptor on cell proliferation and migration in rat adipose-derived stem cells

European Journal of Histochemistry, 2020
Adipose-derived stem cells (ASCs) are an attractive source for regenerative medicine as they can be easily isolated, rapidly expandable in culture and show excellent in vitro differentiation potential.
Marta Pernarella, Roberta Piovesana, Carlo Matera, Alessandro Faroni, Mario Fiore, Luciana Dini, Adam J. Reid, Clelia Dallanoce, Ada Maria Tata   +8 more
doaj   +1 more source

Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice

Cells, 2023
Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng, Jürgen Wess, Christian Alzheimer   +2 more
doaj   +1 more source

Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms [PDF]

Journal of Biological Chemistry, 1995
The phenomenon of acute desensitization of G-protein-coupled receptors has been associated with several events, including receptor phosphorylation, loss of high affinity agonist binding, receptor:G-protein uncoupling, and receptor internalization.
R, Pals-Rylaarsdam, Y, Xu, P, Witt-Enderby, J L, Benovic, M M, Hosey   +4 more
openaire   +2 more sources

Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

Journal of Pharmacological Sciences, 2016
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit, Shingo Takatori, Yoshito Zamami, Mitsuhiro Goda, Poungrat Pakdeechote, Hiromu Kawasaki, Fusako Takayama   +6 more
doaj   +1 more source

Acetylcholine-induced inhibition of presynaptic calcium signals and transmitter release in the frog neuromuscular junction

Frontiers in Physiology, 2016
Acetylcholine (ACh), released from axonal terminals of motor neurones in neuromuscular junctions regulates the efficacy of neurotransmission through activation of presynaptic nicotinic and muscarinic autoreceptors.
Eduard Khaziev, Eduard Khaziev, Eduard Khaziev, Dmitry Samigullin, Dmitry Samigullin, Dmitry Samigullin, Nikita Zhilyakov, Nikita Zhilyakov, Nijaz Fatikhov, Ellya Bukharaeva, Ellya Bukharaeva, Alexej Verkhratsky, Evgeny Nikolsky, Evgeny Nikolsky, Evgeny Nikolsky   +14 more
doaj   +1 more source

Tracking Voltage-Sensitive Movements of the M2 Muscarinic Acetylcholine Receptor [PDF]

Biophysical Journal, 2015
Numerous G protein-coupled receptors (GPCRs) have been shown to change their activity levels in response to changes in membrane potential. More recently, it has been directly demonstrated that these changes in activity reflect underlying changes in conformational state.
Priest, Michael F., Dekel, Noa, Barchad-Avitzur, Ofra, Ben-Chaim, Yair, Bezanilla, Francisco   +4 more
openaire   +1 more source

Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer’s Disease: an Analysis Based on Network Pharmacology

Digital Chinese Medicine, 2018
: Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by ...
Wei-Jie Qiang, Ying Chen, Fu-Yuan He, Mei-Feng Xiao, Wei-Yan Cai, Yi-Fei Dai, Qing Yang, Yu-Jie Li, Xiao-Gang Weng, Qi Li, Ya-Jie Wang, Xiao-Xin Zhu   +11 more
doaj   +1 more source

Emerging Roles of Cholinergic Receptors in Schwann Cell Development and Plasticity

Biomedicines, 2022
The cross talk between neurons and glial cells during development, adulthood, and disease, has been extensively documented. Among the molecules mediating these interactions, neurotransmitters play a relevant role both in myelinating and non-myelinating ...
Roberta Piovesana, Adam J. Reid, Ada Maria Tata   +2 more
doaj   +1 more source