Results 1 to 10 of about 8,575 (176)

Mechanisms of carbachol oscillations

open access: yesBMC Neuroscience, 2007
Netoff Theoden I   +2 more
doaj   +3 more sources

Phytochemical Analysis, Antispasmodic, Myorelaxant, and Antioxidant Effect of Dysphania ambrosioides (L.) Mosyakin and Clemants Flower Hydroethanolic Extracts and Its Chloroform and Ethyl Acetate Fractions

open access: yesMolecules, 2021
Dysphania ambrosioides (L.) Mosyakin and Clemants is an annual or ephemeral perennial herb used traditionally in the Mediterranean region in folk medicine to treat various illnesses, including those related to the digestive system.
Fahd Kandsi   +9 more
doaj   +1 more source

Water Drinking Behavior Associated with Aversive Arousal in Rats: An Integrative Approach

open access: yesBrain Sciences, 2022
Cholinergic muscarinic stimulation of vast areas of the limbic brain induced a well-documented polydipsia in laboratory rats. This excessive water-drinking behavior has not received any convincing biological and physiological interpretation for the last ...
Stefan M. Brudzynski
doaj   +1 more source

KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells

open access: yesFrontiers in Physiology, 2020
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin   +4 more
doaj   +1 more source

Resilient Hippocampal Gamma Rhythmogenesis and Parvalbumin-Expressing Interneuron Function Before and After Plaque Burden in 5xFAD Alzheimer’s Disease Model

open access: yesFrontiers in Synaptic Neuroscience, 2022
Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN) function as a precipitating factor underlying abnormalities in network synchrony, oscillatory rhythms, and cognition associated with Alzheimer’s disease (AD).
Connie A. Mackenzie-Gray Scott   +9 more
doaj   +1 more source

Muscarinic Receptors as Targets for Metronomic Therapy in Ovarian Cancer

open access: yesDüzce Tıp Fakültesi Dergisi, 2023
Aim: In this study, the effects of muscarinic acetylcholine receptor (mAChR) agonist carbachol on the proliferation of cisplatin-resistant (A2780cis) and cisplatin-free (SKOV-3) ovarian cancer cell line were for the first time investigated to further ...
Fatma Söylemez   +1 more
doaj   +1 more source

Intracellular stored calcium plays a minor role in Gq-coupled receptor-mediated contraction in rat airway smooth muscle

open access: yesLife Sciences, Medicine and Biomedicine, 2018
The general notion of activation of Gq-protein coupled receptors involves the mobilisation of stored and extracellular calcium and leads to smooth muscle tissue contraction.
Kayatri Govindaraju   +3 more
doaj   +1 more source

Medial Septum Modulates Cellular Response Induced in Hippocampus on Microinjection of Cholinergic Agonists into Hypothalamic Lateral Supramammillary Nucleus

open access: yesFrontiers in Neuroanatomy, 2017
Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and ...
Mohammed Z. Ariffin   +4 more
doaj   +1 more source

The Muscarinic Acetylcholine M2 Receptor-Induced Nitration of p190A by eNOS Increases RhoA Activity in Cardiac Myocytes

open access: yesCells, 2023
p190RhoGAP, which exists in two paralogs, p190RhoGAP-A (p190A) and p190RhoGAP-B (p190B), is a GTPase activating protein (GAP) contributing to the regulation of the cellular activity of RhoGTPases.
Magdolna K. Levay   +3 more
doaj   +1 more source

Carbachol and Nicotine in Prefrontal Cortex Have Differential Effects on Sleep-Wake States

open access: yesFrontiers in Neuroscience, 2020
The role of the brainstem cholinergic system in the regulation of sleep-wake states has been studied extensively but relatively little is known about the role of cholinergic mechanisms in prefrontal cortex in the regulation of sleep-wake states.
Anjum Parkar   +11 more
doaj   +1 more source

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