Results 1 to 10 of about 28,706 (230)

In vitro study of spontaneous motility and cholinergic responses in the human Hirschsprung's disease colon [PDF]

open access: yesFrontiers in Pediatrics
BackgroundThe current standard treatment of Hirschsprung's disease (HD) involves complete resection of the aganglionic intestinal segment with routine rectal irrigation pre- and postoperatively.
Felix Schulze   +7 more
doaj   +2 more sources

Comparisons of urinary bladder responses to common antimuscarinics reveals unique effects of darifenacin [PDF]

open access: yesFrontiers in Physiology
IntroductionAntimuscarinics are the first-line pharmaceutical treatment for overactive bladder (OAB). However, some literature suggests that responses to these antimuscarinics can influence a variety of non-muscarinic receptors.
Vineesha Veer   +2 more
doaj   +2 more sources

Mechanisms of carbachol oscillations

open access: yesBMC Neuroscience, 2007
Netoff Theoden I   +2 more
doaj   +3 more sources

Water Drinking Behavior Associated with Aversive Arousal in Rats: An Integrative Approach

open access: yesBrain Sciences, 2022
Cholinergic muscarinic stimulation of vast areas of the limbic brain induced a well-documented polydipsia in laboratory rats. This excessive water-drinking behavior has not received any convincing biological and physiological interpretation for the last ...
Stefan M. Brudzynski
doaj   +1 more source

A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation [PDF]

open access: yes, 2004
An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing.
Alvarado, Juan Carlos   +5 more
core   +4 more sources

KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells

open access: yesFrontiers in Physiology, 2020
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin   +4 more
doaj   +1 more source

Resilient Hippocampal Gamma Rhythmogenesis and Parvalbumin-Expressing Interneuron Function Before and After Plaque Burden in 5xFAD Alzheimer’s Disease Model

open access: yesFrontiers in Synaptic Neuroscience, 2022
Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN) function as a precipitating factor underlying abnormalities in network synchrony, oscillatory rhythms, and cognition associated with Alzheimer’s disease (AD).
Connie A. Mackenzie-Gray Scott   +9 more
doaj   +1 more source

Phytochemical Analysis, Antispasmodic, Myorelaxant, and Antioxidant Effect of Dysphania ambrosioides (L.) Mosyakin and Clemants Flower Hydroethanolic Extracts and Its Chloroform and Ethyl Acetate Fractions

open access: yesMolecules, 2021
Dysphania ambrosioides (L.) Mosyakin and Clemants is an annual or ephemeral perennial herb used traditionally in the Mediterranean region in folk medicine to treat various illnesses, including those related to the digestive system.
Fahd Kandsi   +9 more
doaj   +1 more source

Muscarinic Receptors as Targets for Metronomic Therapy in Ovarian Cancer

open access: yesDüzce Tıp Fakültesi Dergisi, 2023
Aim: In this study, the effects of muscarinic acetylcholine receptor (mAChR) agonist carbachol on the proliferation of cisplatin-resistant (A2780cis) and cisplatin-free (SKOV-3) ovarian cancer cell line were for the first time investigated to further ...
Fatma Söylemez   +1 more
doaj   +1 more source

Carbachol and Nicotine in Prefrontal Cortex Have Differential Effects on Sleep-Wake States

open access: yesFrontiers in Neuroscience, 2020
The role of the brainstem cholinergic system in the regulation of sleep-wake states has been studied extensively but relatively little is known about the role of cholinergic mechanisms in prefrontal cortex in the regulation of sleep-wake states.
Anjum Parkar   +11 more
doaj   +1 more source

Home - About - Disclaimer - Privacy