Results 31 to 40 of about 14,304 (180)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2009 .: Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine.
Koichi Iwanaga +4 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley +1 more source
Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
British Journal of Pharmacology, EarlyView.Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
Journal of Pharmacological Sciences, 2007 Phosphoinositide-3 kinase (PI3K) and phospholipase C (PLC) utilize the same phosphoinositides as substrates to produce different signaling molecules. These enzymes are activated by a similar set of cell signaling mechanisms, i.e., tyrosine kinases and G ...
Mitsuhiro Morita +3 more
doaj +1 more source
Clinical and Experimental Obstetrics & Gynecology, 2020 Aim: Pharmacologic parasympathetic nerve stimulation markedly reduces brain damage in a newborn rat model of hypoxia-ischemia (HI). Our aim is to determine whether a brain-protective effect can be achieved by parasympathetic nerve stimulation even with ...
S. Furukawa, L. Yang, H. Sameshima
doaj +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
Time‐dependent bladder activity changes in streptozotocin‐induced female diabetic rats
Physiological ReportsThis study aimed to investigate the long‐term physiological and morphological changes in the bladders of diabetic rats. Sixty‐nine female Sprague–Dawley rats were divided into a control and six diabetic (3 days and 2, 4, 8, 12, and 24 weeks after ...
Keiichiro Izumi +7 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 1998 In the present study, we report that low concentrations of the glutamate ionotropic agonist kainate decreased the turnover of [3H]-phosphoinositides ([3H]-InsPs) induced by muscarinic receptors in the chick embryonic retina.
G. Sanches, A.L.M. Ventura
doaj +1 more source
Transglutaminases (TGs) in ocular and periocular tissues: effect of muscarinic agents on TGs in scleral fibroblasts. [PDF]
PLoS ONE, 2011 OBJECTIVE: To investigate the expression of transglutaminases (TGs) in the ocular surface, the eyelid margin and associated glands and to determine effect of muscarinic agents on TGs in scleral fibroblasts (SF).
V A Barathi +5 more
doaj +1 more source