Results 51 to 60 of about 8,575 (176)

Inhibition of carbachol-induced inositol phosphate accumulation in the embryonic retina promoted by kainate and veratridine

Brazilian Journal of Medical and Biological Research, 1998
In the present study, we report that low concentrations of the glutamate ionotropic agonist kainate decreased the turnover of [3H]-phosphoinositides ([3H]-InsPs) induced by muscarinic receptors in the chick embryonic retina.
G. Sanches, A.L.M. Ventura
doaj   +1 more source

Combination of lipopolysaccharide and hypoxia-ischemia attenuates cholinergic anti-inflammatory effect in newborn rat brains

Clinical and Experimental Obstetrics & Gynecology, 2020
Aim: Pharmacologic parasympathetic nerve stimulation markedly reduces brain damage in a newborn rat model of hypoxia-ischemia (HI). Our aim is to determine whether a brain-protective effect can be achieved by parasympathetic nerve stimulation even with ...
S. Furukawa, L. Yang, H. Sameshima
doaj   +1 more source

Transglutaminases (TGs) in ocular and periocular tissues: effect of muscarinic agents on TGs in scleral fibroblasts. [PDF]

PLoS ONE, 2011
OBJECTIVE: To investigate the expression of transglutaminases (TGs) in the ocular surface, the eyelid margin and associated glands and to determine effect of muscarinic agents on TGs in scleral fibroblasts (SF).
V A Barathi, Sung R Weon, Queenie S W Tan, Kwan J Lin, Louis Tong, Roger W Beuerman   +5 more
doaj   +1 more source

Effects of Trazodone on Testicular Morphology, Sperm Parameters and Contractility of the Distal Cauda Epididymal Duct in Rats

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Trazodone is an antidepressant approved for the treatment of major depressive disorder and is associated with a low incidence of sexual dysfunction. However, its effects on male reproductive health are not yet fully understood. Therefore, this study aimed to evaluate the effects of repeated trazodone administration on reproductive parameters ...
Maria Santana da Silva, Vitória Barros Marques, Fernanda Karoline Oliveira da Silva, Maele Oliveira de Sena, Yanka do Vale Carvalho, Bruna da Silva Figueiredo, Luana Talinne da Costa Gomes, Samia Ellen Alves Fernandes, Edherlayne Bezerra dos Santos Silva, Jackson Nazareno Gomes de Lima, Anna Karynna Alves de Alencar Rocha, Expedito Silva do Nascimento Junior, Elaine Cristina Gavioli, Edilson Dantas da Silva Junior   +13 more
wiley   +1 more source

Carbachol-induced inositol phosphate formation during rat cochlea development [PDF]

, 1990
International audienceThe age related-intensity developmental pattern of the phosphoinositide breakdown, which leads to the formation of intracellularsecond messengers, was investigated in rat cochleas by measuring the accumulation of inositol phosphates
Guiramand, J., Lenoir, M., Pujol, R., Récasens, Max, Bartolami, Sylvain   +4 more
core   +2 more sources

Phosphatase Inhibition Attenuates the Negative Inotropic Effect of Muscarinic Receptors in the Presence of Serotonin

Current Issues in Molecular Biology
Cantharidin (CANT) and sodium fluoride inhibit serine/threonine phosphatase (PP) 1 and PP2A in the heart. We hypothesized that Cant and sodium fluoride could weaken the reduction in force by carbachol in the presence of serotonin in human right atrial ...
Rebecca Schwarz, Britt Hofmann, Ulrich Gergs, Uwe Kirchhefer, Joachim Neumann   +4 more
doaj   +1 more source

Gastrin and Nitric Oxide Production in Cultured Gastric Antral Mucosa Are Altered in Response to a Gastric Digest of a Dietary Supplement

Frontiers in Veterinary Science, 2021
In vitro organ culture can provide insight into isolated mucosal responses to particular environmental stimuli. The objective of the present study was to investigate the impact of a prolonged culturing time as well as the addition of acidic gastric fluid
Jennifer L. MacNicol, Wendy Pearson
doaj   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source

Carbachol-induced contraction in experimental intestinal atresia.

, 2013
(A) Typical recording of carbachol dose-response stimulation of contraction in proximal segment (Upper Panel). Proximal segments showed a significant increase in the contractile response starting at 1 µM carbachol (Lower Panel).
Maud Pousset (411073), Anais Victor (411069), Celine Grosos (411070), Sandrine Menard (5654848), Rodolphe Soret (411071), Nadine Cerf-Bensussan (38071), Michel Neunlist (242012), Frederique Sauvat (5654851), Yann Revillon (411074), Naziha Khen-Dunlop (411068), Sabine Sarnacki (89808), Nicolas Goudin (411072)   +11 more
core   +1 more source