Results 71 to 80 of about 28,706 (230)

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]

, 2016
Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark, Han, Xue, Kondabolu, Krishnakanth, Kopell, Nancy, McCarthy, Michelle M., Roberts, Erik A.   +5 more
core   +1 more source

Coumarins and Their Derivatives in Animal Models of Asthma: A Systematic Review

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
Mast cells drive early allergic asthma by releasing histamine, interleukins and prostaglandins, causing airway hyperresponsiveness, mucus overproduction and inflammation. These events sustain symptoms and promote structural remodelling, contributing to the progression of the disease.
Iêda Maria dos Santos, João Lázaro de Oliveira Rocha, Edilson Beserra de Alencar Filho, Fabrício Souza Silva   +3 more
wiley   +1 more source

Hydrogen Sulfide (H2S) and Reactive Oxygen Species (ROS) Scavengers Have a Protective Effect on Carbachol-induced Contractions That are Impaired by High Glucose in Detrusor Smooth Muscle

Journal of Urological Surgery
Objective: Urinary bladder dysfunction, that is one of the most common diabetic complications, is associated with bladder overactivity, increased bladder capacity and also impaired bladder smooth muscle contractions.
Merve Denizalti, Nezahat Tugba Durlu Kandilci   +1 more
doaj   +1 more source

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function [PDF]

, 2014
<b>Objective:</b><p></p> Mitochondria-derived reactive oxygen species (ROS) play important roles in the development of cardiovascular disease highlighting the need for novel targeted therapies.
Adlam, Cai, Calhoun, Chacko, Chandran, DAgostino, Dai, Dai, Dikalova, Doughan, Evans, Flores-Munoz, Flores-Munoz, Gane, Graham, Graham, Gutierrez, Halliwell, Jalil, Jeffs, Landmesser, London, Lowes, Mercer, Messerli, Murphy, Murphy, Nakagami, Nakamura, Nozoe, Qin, Rajagopalan, Roman, Ross, Snow, Watkins, Winterbourn, Yang, Yasunari, Zhang, Zhang, Zorov   +41 more
core   +1 more source

Nanomaterial‐Based Inkjet Printing for Electrochemical Sensing

Small, Volume 22, Issue 10, 17 February 2026.
Inkjet printing provides a digitally controlled, versatile, and highly reproducible method for fabricating and functionalizing sensing devices. This Perspective highlights how homogeneous, material‐efficient deposition enables precise patterning of functional inks and scalable integration of sensors for chemical and biological detection. The discussion
David Panáček, Massimo Urban, Alessandro Silvestri, Ivan Dědek, Martin‐Alex Nalepa, Arben Merkoçi, Maurizio Prato, Michal Otyepka   +7 more
wiley   +1 more source

Pharmacological basis for the medicinal use of cardamom in asthma

Bangladesh Journal of Pharmacology, 2011
Cardamom (Elettaria cardamomum) is widely used in folk medicine for the treatment of asthma. This study describes its airways relaxant potential, with elucidation of possible underlying mechanism.
Arif ullah Khan, Qaiser Jabeen Khan, Anwar Hassan Gilani   +2 more
doaj   +1 more source

In vitro functional properties of the rat bladder regenerated by the bladder acellular matrix graft. [PDF]

, 1998
PurposeTo assess the response of rat urinary bladder regenerated by the homologous bladder acellular matrix graft (BAMG) to in vitro electrical and pharmacologic stimuli.Materials and methodsIn Sprague-Dawley rats, partial cystectomy (>50%) was ...
Dahiya, R, Dahms, SE, Lue, TF, Nunes, LS, Piechota, HJ, Tanagho, EA   +5 more
core   +1 more source

Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]

, 2010
Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S, Drewke, C., Gomeza, J., Hennen, S., Janssen, N., Kebig, A., Kostenis, E., Merten, N., Milligan, G., Mohr, K., Mohr-Andra, M., Muller, A., Schmidt, J., Schroder, R., Smith, N.J., Wenzel, J., Zahn, S.   +16 more
core   +1 more source